| Entry |
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| Symbol |
GCK, FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, PNDM1
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| Name |
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| KO |
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| Organism |
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| Pathway |
| hsa00520 | Amino sugar and nucleotide sugar metabolism |
| hsa00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| hsa01250 | Biosynthesis of nucleotide sugars |
| hsa04950 | Maturity onset diabetes of the young |
| hsa05230 | Central carbon metabolism in cancer |
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| Module |
| hsa_M00001 | Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate |
| hsa_M00549 | Nucleotide sugar biosynthesis, glucose => UDP-glucose |
| hsa_M00892 | UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc |
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| Disease |
| H00410 | Maturity onset diabetes of the young (MODY) |
| H00512 | Permanent neonatal diabetes mellitus |
| H01267 | Familial hyperinsulinemic hypoglycemia |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
2645 (GCK)
00052 Galactose metabolism
2645 (GCK)
00500 Starch and sucrose metabolism
2645 (GCK)
00520 Amino sugar and nucleotide sugar metabolism
2645 (GCK)
09110 Biosynthesis of other secondary metabolites
00524 Neomycin, kanamycin and gentamicin biosynthesis
2645 (GCK)
09150 Organismal Systems
09152 Endocrine system
04911 Insulin secretion
2645 (GCK)
04910 Insulin signaling pathway
2645 (GCK)
04922 Glucagon signaling pathway
2645 (GCK)
04917 Prolactin signaling pathway
2645 (GCK)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
2645 (GCK)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
2645 (GCK)
04950 Maturity onset diabetes of the young
2645 (GCK)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.2 glucokinase
2645 (GCK)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
7:complement(44143213..44189439)
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| AA seq |
465 aa
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ |
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| NT seq |
1398 nt +upstreamnt +downstreamnt
atgctggacgacagagccaggatggaggccgccaagaaggagaaggtagagcagatcctg
gcagagttccagctgcaggaggaggacctgaagaaggtgatgagacggatgcagaaggag
atggaccgcggcctgaggctggagacccatgaagaggccagtgtgaagatgctgcccacc
tacgtgcgctccaccccagaaggctcagaagtcggggacttcctctccctggacctgggt
ggcactaacttcagggtgatgctggtgaaggtgggagaaggtgaggaggggcagtggagc
gtgaagaccaaacaccagatgtactccatccccgaggacgccatgaccggcactgctgag
atgctcttcgactacatctctgagtgcatctccgacttcctggacaagcatcagatgaaa
cacaagaagctgcccctgggcttcaccttctcctttcctgtgaggcacgaagacatcgat
aagggcatccttctcaactggaccaagggcttcaaggcctcaggagcagaagggaacaat
gtcgtggggcttctgcgagacgctatcaaacggagaggggactttgaaatggatgtggtg
gcaatggtgaatgacacggtggccacgatgatctcctgctactacgaagaccatcagtgc
gaggtcggcatgatcgtgggcacgggctgcaatgcctgctacatggaggagatgcagaat
gtggagctggtggagggggacgagggccgcatgtgcgtcaataccgagtggggcgccttc
ggggactccggcgagctggacgagttcctgctggagtatgaccgcctggtggacgagagc
tctgcaaaccccggtcagcagctgtatgagaagctcataggtggcaagtacatgggcgag
ctggtgcggcttgtgctgctcaggctcgtggacgaaaacctgctcttccacggggaggcc
tccgagcagctgcgcacacgcggagccttcgagacgcgcttcgtgtcgcaggtggagagc
gacacgggcgaccgcaagcagatctacaacatcctgagcacgctggggctgcgaccctcg
accaccgactgcgacatcgtgcgccgcgcctgcgagagcgtgtctacgcgcgctgcgcac
atgtgctcggcggggctggcgggcgtcatcaaccgcatgcgcgagagccgcagcgaggac
gtaatgcgcatcactgtgggcgtggatggctccgtgtacaagctgcaccccagcttcaag
gagcggttccatgccagcgtgcgcaggctgacgcccagctgcgagatcaccttcatcgag
tcggaggagggcagtggccggggcgcggccctggtctcggcggtggcctgtaagaaggcc
tgtatgctgggccagtga |
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