KEGG   Homo sapiens (human): 26524
Entry
26524             CDS       T01001                                 
Symbol
LATS2, KPM
Name
(RefSeq) large tumor suppressor kinase 2
  KO
K08791  serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04390  Hippo signaling pathway
hsa04392  Hippo signaling pathway - multiple species
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    26524 (LATS2)
   04392 Hippo signaling pathway - multiple species
    26524 (LATS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    26524 (LATS2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     26524 (LATS2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  NDR family
   26524 (LATS2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C ABC1 UBA APH Haspin_kinase Pox_ser-thr_kin Kinase-like Kdo
Other DBs
NCBI-GeneID: 26524
NCBI-ProteinID: NP_055387
OMIM: 604861
HGNC: 6515
Ensembl: ENSG00000150457
UniProt: Q9NRM7
Structure
Position
13:complement(20973036..21061586)
AA seq 1088 aa
MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
EGCQPVYV
NT seq 3267 nt   +upstreamnt  +downstreamnt
atgaggccaaagacttttcctgccacgacttattctggaaatagccggcagcgactgcaa
gagattcgtgaggggttaaaacagccatccaagtcttcggttcaggggctacccgcagga
ccaaacagtgacacttccctggatgccaaagtcctggggagcaaagatgccaccaggcag
cagcagcagatgagagccaccccaaagttcggaccttatcagaaagccttgagggaaatc
agatattccttgttgccttttgctaatgaatcgggcacctctgcagctgcagaagtgaac
cggcaaatgctgcaggaactggtgaacgcaggatgcgaccaggagatggctggccgagct
ctcaagcagactggcagcaggagcatcgaggccgccctggagtacatcagcaagatgggc
tacctggacccgaggaatgagcagattgtgcgggtcattaagcagacctccccaggaaag
gggctcatgccaaccccagtgacgcggaggcccagcttcgaaggaaccggcgattcgttt
gcgtcctaccaccagctgagcggtaccccctacgagggcccaagcttcggcgctgacggc
cccacggcgctggaggagatgccgcggccgtacgtggactaccttttccccggagtcggc
ccccacgggcccggccaccagcaccagcacccacccaagggctacggtgccagcgtagag
gcagcaggggcacacttcccgctgcagggcgcgcactacgggcggccgcacctgctggtg
cctggggaacccctgggctacggagtgcagcgcagcccctccttccagagcaagacgccg
ccggagaccgggggttacgccagcctgcccacgaagggccagggaggaccgccaggcgcc
ggcctcgctttcccaccccctgccgccgggctctacgtgccgcacccacaccacaagcag
gccggtcccgcggcccaccagctgcatgtgctgggctcccgcagccaggtgttcgccagc
gacagccccccgcagagcctgctcactccctcgcggaacagcctcaacgtggacctgtat
gaattgggcagcacctccgtccagcagtggccggctgccaccctggcccgccgggactcc
ctgcagaagccgggcctggaggcgccgccgcgcgcgcacgtggccttccggcctgactgc
ccagtgcccagcaggaccaactccttcaacagccaccagccgcggcccggtccgcctggc
aaggccgagccctccctgcccgcccccaacaccgtgacggctgtcacggccgcgcacatc
ttgcacccggtgaagagcgtgcgtgtgctgaggccggagccgcagacggctgtggggccc
tcgcaccccgcctgggtgcccgcgcctgccccggcccccgcccccgcccccgccccggct
gcggagggcttggacgccaaggaggagcatgccctggcgctgggcggcgcaggcgccttc
ccgctggacgtggagtacggaggcccagaccggaggtgcccgcctccgccctacccgaag
cacctgctgctgcgcagcaagtcggagcagtacgacctggacagcctgtgcgcaggcatg
gagcagagcctccgtgcgggccccaacgagcccgagggcggcgacaagagccgcaaaagc
gccaagggggacaaaggcggaaaggataaaaagcagattcagacctctcccgttcccgtc
cgcaaaaacagcagagacgaagagaagagagagtcacgcatcaagagctactcgccatac
gcctttaagttcttcatggagcagcacgtggagaatgtcatcaaaacctaccagcagaag
gttaaccggaggctgcagctggagcaagaaatggccaaagctggactctgtgaagctgag
caggagcagatgcggaagatcctctaccagaaagagtctaattacaacaggttaaagagg
gccaagatggacaagtctatgtttgtcaagatcaaaaccctggggatcggtgcctttgga
gaagtgtgccttgcttgtaaggtggacactcacgccctgtacgccatgaagaccctaagg
aaaaaggatgtcctgaaccggaatcaggtggcccacgtcaaggccgagagggacatcctg
gccgaggcagacaatgagtgggtggtcaaactctactactccttccaagacaaagacagc
ctgtactttgtgatggactacatccctggtggggacatgatgagcctgctgatccggatg
gaggtcttccctgagcacctggcccggttctacatcgcagagctgactttggccattgag
agtgtccacaagatgggcttcatccaccgagacatcaagcctgataacattttgatagat
ctggatggtcacattaaactcacagatttcggcctctgcactgggttcaggtggactcac
aattccaaatattaccagaaagggagccatgtcagacaggacagcatggagcccagcgac
ctctgggatgatgtgtctaactgtcggtgtggggacaggctgaagaccctagagcagagg
gcgcggaagcagcaccagaggtgcctggcacattcactggtggggactccaaactacatc
gcacccgaggtgctcctccgcaaagggtacactcaactctgtgactggtggagtgttgga
gtgattctcttcgagatgctggtggggcagccgccctttttggcacctactcccacagaa
acccagctgaaggtgatcaactgggagaacacgctccacattccagcccaggtgaagctg
agccctgaggccagggacctcatcaccaagctgtgctgctccgcagaccaccgcctgggg
cggaatggggccgatgacctgaaggcccaccccttcttcagcgccattgacttctccagt
gacatccggaagcagccagccccctacgttcccaccatcagccaccccatggacacctcg
aatttcgaccccgtagatgaagaaagcccttggaacgatgccagcgaaggtagcaccaag
gcctgggacacactcacctcgcccaataacaagcatcctgagcacgcattttacgaattc
accttccgaaggttctttgatgacaatggctacccctttcgatgcccaaagccttcagga
gcagaagcttcacaggctgagagctcagatttagaaagctctgatctggtggatcagact
gaaggctgccagcctgtgtacgtgtag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (34)   
   RefSeq(nuc) (14)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   Pfam (10)   
All databases (96)   

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