KEGG   Homo sapiens (human): 2677
Entry
2677              CDS       T01001                                 
Symbol
GGCX, VKCFD1
Name
(RefSeq) gamma-glutamyl carboxylase
  KO
K10106  vitamin K-dependent gamma-carboxylase [EC:4.1.1.90]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Disease
H00560  Pseudoxanthoma elasticum
H00995  Combined deficiency of vitamin K-dependent clotting factors
H01205  Coumarin resistance
Drug target
Anisindione: D07457
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    2677 (GGCX)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.90  peptidyl-glutamate 4-carboxylase
     2677 (GGCX)
SSDB
Motif
Pfam: VKG_Carbox Cupin_2 Ppnp
Other DBs
NCBI-GeneID: 2677
NCBI-ProteinID: NP_000812
OMIM: 137167
HGNC: 4247
Ensembl: ENSG00000115486
UniProt: P38435
Position
2:complement(85544720..85561493)
AA seq 758 aa
MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTD
PASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYT
IMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYW
SVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSP
FKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFS
YVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRH
QLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRT
GELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQR
IFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHL
ENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYM
YVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFL
RRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEV
TYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
NT seq 2277 nt   +upstreamnt  +downstreamnt
atggcggtgtctgccgggtccgcgcggacctcgcccagctcagataaagtacagaaagac
aaggctgaactgatctcagggcccaggcaggacagccgaatagggaaactcttgggtttt
gagtggacagatttgtccagttggcggaggctggtgaccctgctgaatcgaccaacggac
cctgcaagcttagctgtctttcgttttctttttgggttcttgatggtgctagacattccc
caggagcgggggctcagctctctggaccggaaataccttgatgggctggatgtgtgccgc
ttccccttgctggatgccctacgcccactgccacttgactggatgtatcttgtctacacc
atcatgtttctgggggcactgggcatgatgctgggcctgtgctaccggataagctgtgtg
ttattcctgctgccatactggtatgtgtttctcctggacaagacatcatggaacaaccac
tcctatctgtatgggttgttggcctttcagctaacattcatggatgcaaaccactactgg
tctgtggacggtctgctgaatgcccataggaggaatgcccacgtgcccctttggaactat
gcagtgctccgtggccagatcttcattgtgtacttcattgcgggtgtgaaaaagctggat
gcagactgggttgaaggctattccatggaatatttgtcccggcactggctcttcagtccc
ttcaaactgctgttgtctgaggagctgactagcctgctggtcgtgcactggggtgggctg
ctgcttgacctctcagctggtttcctgctcttttttgatgtctcaagatccattggcctg
ttctttgtgtcctacttccactgcatgaattcccagcttttcagcattggtatgttctcc
tacgtcatgctggccagcagccctctcttctgctcccctgagtggcctcggaagctggtg
tcctactgcccccgaaggttgcaacaactgttgcccctcaaggcagcccctcagcccagt
gtttcctgtgtgtataagaggagccggggcaaaagtggccagaagccagggctgcgccat
cagctgggagctgccttcaccctgctctacctcctggagcagctattcctgccctattct
cattttctcacccagggctataacaactggacaaatgggctgtatggctattcctgggac
atgatggtgcactcccgctcccaccagcacgtgaagatcacctaccgtgatggccgcact
ggcgaactgggctaccttaaccctggggtatttacacagagtcggcgatggaaggatcat
gcagacatgctgaagcaatatgccacttgcctgagccgcctgcttcccaagtataatgtc
actgagccccagatctactttgatatttgggtctccatcaatgaccgcttccagcagagg
atttttgaccctcgtgtggacatcgtgcaggccgcttggtcaccctttcagcgcacatcc
tgggtgcaaccactcttgatggacctgtctccctggagggccaagttacaggaaatcaag
agcagcctagacaaccacactgaggtggtcttcattgcagatttccctggactgcacttg
gagaattttgtgagtgaagacctgggcaacactagcatccagctgctgcagggggaagtg
actgtggagcttgtggcagaacagaagaaccagactcttcgagagggagaaaaaatgcag
ttgcctgctggtgagtaccataaggtgtatacgacatcacctagcccttcttgctacatg
tacgtctatgtcaacactacagagcttgcactggagcaagacctggcatatctgcaagaa
ttaaaggaaaaggtggagaatggaagtgaaacagggcctctacccccagagctgcagcct
ctgttggaaggggaagtaaaagggggccctgagccaacacctctggttcagacctttctt
agacgccaacaaaggctccaggagattgaacgccggcgaaatactcctttccatgagcga
ttcttccgcttcttgttgcgaaagctctatgtctttcgccgcagcttcctgatgacttgt
atctcacttcgaaatctgatattaggccgtccttccctggagcagctggcccaggaggtg
acttatgcaaacttgagaccctttgaggcagttggagaactgaatccctcaaacacggat
tcttcacattctaatcctcctgagtcaaatcctgatcctgtccactcagagttctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (45)   
   RefSeq(nuc) (11)   
   GenBank (17)   
   EMBL (17)   
Protein domain (3)   
   Pfam (3)   
All databases (103)   

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