KEGG   Homo sapiens (human): 27330
Entry
27330             CDS       T01001                                 
Symbol
RPS6KA6, PP90RSK4, RSK-4, RSK4, S6K-alpha-6, p90RSK6
Name
(RefSeq) ribosomal protein S6 kinase A6
  KO
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04114  Oocyte meiosis
hsa04150  mTOR signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04931  Insulin resistance
hsa05135  Yersinia infection
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06526  MAPK signaling
  Element
N01601  ERK-RSK signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    27330 (RPS6KA6)
   04150 mTOR signaling pathway
    27330 (RPS6KA6)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    27330 (RPS6KA6)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    27330 (RPS6KA6)
  09156 Nervous system
   04720 Long-term potentiation
    27330 (RPS6KA6)
   04722 Neurotrophin signaling pathway
    27330 (RPS6KA6)
  09159 Environmental adaptation
   04714 Thermogenesis
    27330 (RPS6KA6)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    27330 (RPS6KA6)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    27330 (RPS6KA6)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    27330 (RPS6KA6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    27330 (RPS6KA6)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    27330 (RPS6KA6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     27330 (RPS6KA6)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   27330 (RPS6KA6)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     27330 (RPS6KA6)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Kdo Pkinase_fungal Pkinase_C YrbL-PhoP_reg FTA2 Haspin_kinase APH
Other DBs
NCBI-GeneID: 27330
NCBI-ProteinID: NP_001317441
OMIM: 300303
HGNC: 10435
Ensembl: ENSG00000072133
UniProt: Q9UK32
Structure
Position
X:complement(84058346..84188499)
AA seq 745 aa
MGLSTSAIWKNTRVEIVNPYEVKRKVKVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH
VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT
KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA
ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM
APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA
QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF
DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA
QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI
ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV
HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD
AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL
SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ
PVLEPVAASSLAQRRSMKKRTSTGL
NT seq 2238 nt   +upstreamnt  +downstreamnt
atgggtctctctacctcagcaatttggaaaaatactcgagtggaaattgttaatccctat
gaagtaaaacgaaaggtgaaggtaaatggtcttaaaatggttgatgagccaatggaagag
ggagaagcagattcttgtcatgatgaaggagttgttaaagaaatccctattactcatcat
gttaaggaaggctatgagaaagcagatcctgcacagtttgagttgctcaaggttcttggt
caggggtcatttggaaaggtttttcttgttagaaagaagaccggtcctgatgctgggcag
ctctatgcaatgaaggtgttaaaaaaagcctctttaaaagttcgagacagagttcggaca
aagatggagagggatatactggtggaagtaaatcatccatttattgtcaaattgcactat
gcctttcagactgaagggaaactgtacttaatactggattttctcaggggaggagatgtt
ttcacaagattatccaaagaggttctgtttacagaggaagatgtgaaattctacctcgca
gaactggcccttgctttggatcatctgcaccaattaggaattgtttatagagacctgaag
ccagaaaacattttgcttgatgaaataggacatatcaaattaacagattttggactcagc
aaggagtcagtagatcaagaaaagaaggcttactcattttgtggtacagtagagtatatg
gctcctgaagtagtaaataggagaggccattcccagagtgctgattggtggtcatatggt
gttcttatgtttgaaatgcttactggtactctgccatttcaaggtaaagacagaaatgag
accatgaatatgatattaaaagcaaaacttggaatgcctcaatttcttagtgctgaagca
caaagtcttctaaggatgttattcaaaaggaatccagcaaatagattgggatcagaagga
gttgaagaaatcaaaagacatctgttttttgcaaatattgactgggataaattatataaa
agagaagttcaacctcctttcaaacctgcttctggaaaaccagatgatactttttgtttt
gatcctgaatttactgcaaaaacacctaaagattctcccggtttgccagccagtgcaaat
gctcatcagctcttcaaaggattcagctttgttgcaacttctattgcagaagaatataaa
atcactcctatcacaagtgcaaatgtattaccaattgttcagataaatggaaatgctgca
caatttggtgaagtatatgaattgaaggaggatattggtgttggctcctactctgtttgc
aagcgatgcatacatgcaactaccaacatggaatttgcagtgaagatcattgacaaaagt
aagcgagacccttcagaagagattgaaatattgatgcgctatggacaacatcccaacatt
attactttgaaggatgtctttgatgatggtagatatgtttaccttgttacggatttaatg
aaaggaggagagttacttgaccgtattctcaaacaaaaatgtttctcggaacgggaggct
agtgatatactatatgtaataagtaagacagttgactatcttcattgtcaaggagttgtt
catcgtgatcttaaacctagtaatattttatacatggatgaatcagccagtgcagattca
atcaggatatgtgattttgggtttgcaaaacaacttcgaggagaaaatggacttctctta
actccatgctacactgcaaactttgttgcacctgaggttcttatgcaacagggatatgat
gctgcttgtgatatctggagtttaggagtccttttttacacaatgttggctggctacact
ccatttgctaatggccccaatgatactcctgaagagatactgctgcgtataggcaatgga
aaattctctttgagtggtggaaactgggacaatatttcagacggagcaaaggatttgctt
tcccatatgcttcatatggacccacatcagcggtatactgctgaacaaatattaaagcac
tcatggataactcacagagaccagttgccaaatgatcagccaaagagaaatgatgtgtca
catgttgttaagggagcaatggttgcaacatactctgccctgactcacaagacctttcaa
ccagtcctagagcctgtagctgcttcaagcttagcccagcgacggagcatgaaaaagcga
acatcaactggcctgtaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (35)   
   RefSeq(nuc) (17)   
   GenBank (9)   
   EMBL (9)   
3D Structure (3)   
   PDB (3)   
Protein domain (11)   
   Pfam (11)   
All databases (98)   

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