KEGG   Homo sapiens (human): 2740
Entry
2740              CDS       T01001                                 
Symbol
GLP1R, GLP-1, GLP-1-R, GLP-1R
Name
(RefSeq) glucagon like peptide 1 receptor
  KO
K04581  glucagon-like peptide 1 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04911  Insulin secretion
Drug target
Albiglutide: D08843
Avexitide: D11418
Avexitide acetate: D11419
Beinaglutide: D11924
Danuglipron (DG03125): D11910 D11911
Dulaglutide: D09889<JP/US>
Efpeglenatide: D11947
Exenatide: D04121<JP/US>
Insulin degludec and liraglutide: D11567<JP/US>
Insulin glargine and lixisenatide: D11034<JP/US>
Liraglutide: D06404<JP/US>
Lixisenatide: D09729<JP>
Lotiglipron (DG03281): D12555 D12735
Mazdutide: D12225
Orforglipron (DG03257): D12529 D12536
Pegapamodutide: D10970
Pemvidutide: D12861
Retatrutide: D12430
Semaglutide: D10025<JP/US>
Taspoglutide: D09723
Tirzepatide: D11360<JP/US>
Vurolenatide: D12341
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2740 (GLP1R)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2740 (GLP1R)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    2740 (GLP1R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2740 (GLP1R)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Pancreatic peptide
   Glucagon
    2740 (GLP1R)
SSDB
Motif
Pfam: 7tm_2 HRM
Other DBs
NCBI-GeneID: 2740
NCBI-ProteinID: NP_002053
OMIM: 138032
HGNC: 4324
Ensembl: ENSG00000112164
UniProt: P43220 A0A142FHB8
Structure
Position
6:39048781..39091303
AA seq 463 aa
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
NT seq 1392 nt   +upstreamnt  +downstreamnt
atggccggcgcccccggcccgctgcgccttgcgctgctgctgctcgggatggtgggcagg
gccggcccccgcccccagggtgccactgtgtccctctgggagacggtgcagaaatggcga
gaataccgacgccagtgccagcgctccctgactgaggatccacctcctgccacagacttg
ttctgcaaccggaccttcgatgaatacgcctgctggccagatggggagccaggctcgttc
gtgaatgtcagctgcccctggtacctgccctgggccagcagtgtgccgcagggccacgtg
taccggttctgcacagctgaaggcctctggctgcagaaggacaactccagcctgccctgg
agggacttgtcggagtgcgaggagtccaagcgaggggaaagaagctccccggaggagcag
ctcctgttcctctacatcatctacacggtgggctacgcactctccttctctgctctggtt
atcgcctctgcgatcctcctcggcttcagacacctgcactgcaccaggaactacatccac
ctgaacctgtttgcatccttcatcctgcgagcattgtccgtcttcatcaaggacgcagcc
ctgaagtggatgtatagcacagccgcccagcagcaccagtgggatgggctcctctcctac
caggactctctgagctgccgcctggtgtttctgctcatgcagtactgtgtggcggccaat
tactactggctcttggtggagggcgtgtacctgtacacactgctggccttctcggtctta
tctgagcaatggatcttcaggctctacgtgagcataggctggggtgttcccctgctgttt
gttgtcccctggggcattgtcaagtacctctatgaggacgagggctgctggaccaggaac
tccaacatgaactactggctcattatccggctgcccattctctttgccattggggtgaac
ttcctcatctttgttcgggtcatctgcatcgtggtatccaaactgaaggccaatctcatg
tgcaagacagacatcaaatgcagacttgccaagtccacgctgacactcatccccctgctg
gggactcatgaggtcatctttgcctttgtgatggacgagcacgcccgggggaccctgcgc
ttcatcaagctgtttacagagctctccttcacctccttccaggggctgatggtggccata
ttatactgctttgtcaacaatgaggtccagctggaatttcggaagagctgggagcgctgg
cggcttgagcacttgcacatccagagggacagcagcatgaagcccctcaagtgtcccacc
agcagcctgagcagtggagccacggcgggcagcagcatgtacacagccacttgccaggcc
tcctgcagctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (25)   
   KEGG DRUG (25)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (47)   
   PDB (47)   
Protein domain (2)   
   Pfam (2)   
All databases (118)   

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