KEGG   Homo sapiens (human): 283208
Entry
283208            CDS       T01001                                 
Symbol
P4HA3
Name
(RefSeq) prolyl 4-hydroxylase subunit alpha 3
  KO
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
Drug target
Lufironil: D04793
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    283208 (P4HA3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.2  procollagen-proline 4-dioxygenase
     283208 (P4HA3)
SSDB
Motif
Pfam: P4Ha_N 2OG-FeII_Oxy_3 TPR_2 HrpB1_HrpK TPR_12 TPR_8 SPO22 DUF1518
Other DBs
NCBI-GeneID: 283208
NCBI-ProteinID: NP_878907
OMIM: 608987
HGNC: 30135
Ensembl: ENSG00000149380
UniProt: Q7Z4N8
Position
11:complement(74250146..74311640)
AA seq 544 aa
MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEA
RLRDLTRFYDKVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGY
EKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLT
GDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRA
GNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDT
YEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEA
QKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRP
PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIY
ANLSVPVVRNAALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSS
SPED
NT seq 1635 nt   +upstreamnt  +downstreamnt
atgggtcctggggcgcggctggcggcgctgctggcggtgctggcgctcgggacaggagac
ccagaaagggctgcggctcggggcgacacgttctcggcgctgaccagcgtggcgcgcgcc
ctggcgcccgagcgccggctgctggggctgctgaggcggtacctgcgcggggaggaggcg
cggctgcgggacctgactagattctacgacaaggtactttctttgcatgaggattcaaca
acccctgtggctaaccctctgcttgcatttactctcatcaaacgcctgcagtctgactgg
aggaatgtggtacatagtctggaggccagtgagaacatccgagctctgaaggatggctat
gagaaggtggagcaagaccttccagcctttgaggaccttgagggagcagcaagggccctg
atgcggctgcaggacgtgtacatgctcaatgtgaaaggcctggcccgaggtgtctttcag
agagtcactggctctgccatcactgacctgtacagccccaaacggctcttttctctcaca
ggggatgactgcttccaagttggcaaggtggcctatgacatgggggattattaccatgcc
attccatggctggaggaggctgtcagtctcttccgaggatcttacggagagtggaagaca
gaggatgaggcaagtctagaagatgccttggatcacttggcctttgcttatttccgggca
ggaaatgtttcgtgtgccctcagcctctctcgggagtttcttctctacagcccagataat
aagaggatggccaggaatgtcttgaaatatgaaaggctcttggcagagagccccaaccac
gtggtagctgaggctgtcatccagaggcccaatataccccacctgcagaccagagacacc
tacgaggggctatgtcagaccctgggttcccagcccactctctaccagatccctagcctc
tactgttcctatgagaccaattccaacgcctacctgctgctccagcccatccggaaggag
gtcatccacctggagccctacattgctctctaccatgacttcgtcagtgactcagaggct
cagaaaattagagaacttgcagaaccatggctacagaggtcagtggtggcatcaggggag
aagcagttacaagtggagtaccgcatcagcaaaagtgcctggctgaaggacactgttgac
ccaaaactggtgaccctcaaccaccgcattgctgccctcacaggccttgatgtccggcct
ccctatgcagagtatctgcaggtggtgaactatggcatcggaggacactatgagcctcac
tttgaccatgctacgtcaccaagcagccccctctacagaatgaagtcaggaaaccgagtt
gcaacatttatgatctatctgagctcggtggaagctggaggagccacagccttcatctat
gccaacctcagcgtgcctgtggttaggaatgcagcactgttttggtggaacctgcacagg
agtggtgaaggggacagtgacacacttcatgctggctgtcctgtcctggtgggagataag
tgggtggccaacaagtggatacatgagtatggacaggaattccgcagaccctgcagctcc
agccctgaagactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (34)   
   RefSeq(nuc) (12)   
   GenBank (11)   
   EMBL (11)   
Protein domain (8)   
   Pfam (8)   
All databases (75)   

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