KEGG   Homo sapiens (human): 284086
Entry
284086            CDS       T01001                                 
Symbol
NEK8, JCK, NEK12A, NPHP9, RHPD2
Name
(RefSeq) NIMA related kinase 8
  KO
K20877  serine/threonine-protein kinase Nek8 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00537  Nephronophthisis
H00543  Renal-hepatic-pancreatic dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    284086 (NEK8)
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    284086 (NEK8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     284086 (NEK8)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NEK family
   284086 (NEK8)
Cilium and associated proteins [BR:hsa03037]
 Primary cilia and associated proteins
  Other primary cilia associated proteins
   284086 (NEK8)
SSDB
Motif
Pfam: Pkinase RCC1 PK_Tyr_Ser-Thr RCC1_2 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 284086
NCBI-ProteinID: NP_835464
OMIM: 609799
HGNC: 13387
Ensembl: ENSG00000160602
UniProt: Q86SG6
Position
17:28728788..28743455
AA seq 692 aa
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH
PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH
THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY
NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS
LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR
GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPP
LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN
GCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR
ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP
HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG
SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQL
DETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
NT seq 2079 nt   +upstreamnt  +downstreamnt
atggagaagtacgagcggatccgagtggtggggagaggtgccttcgggattgtgcacctg
tgcctgcgaaaggctgaccagaagctggtgatcatcaagcagattccagtggaacagatg
accaaggaagagcggcaggcagcccagaatgagtgccaggtcctcaagctgctcaaccac
cccaatgtcattgagtactacgagaacttcctggaagacaaagcccttatgatcgccatg
gaatatgcaccaggcggcactctggctgagttcatccaaaagcgctgtaattccctgctg
gaggaggagaccatcctgcacttcttcgtgcagatcctgcttgcactgcatcatgtgcac
acccacctcatcctgcaccgagacctcaagacccagaacatcctgcttgacaaacaccgc
atggtcgtcaagatcggtgatttcggcatctccaagatccttagcagcaagagcaaggcc
tacacggtggtgggtaccccatgctatatctcccctgagctgtgtgagggcaagccctac
aaccagaagagtgacatctgggccctgggctgtgtcctctacgagctggccagcctcaag
agggctttcgaggctgcgaacttgccagcactggtgctgaagatcatgagtggcaccttt
gcacctatctctgaccggtacagccctgagcttcgccagctggtcctgagtctactcagc
ctggagcctgcccagcggccaccactcagccacatcatggcacagcccctctgcatccgt
gccctcctcaacctccacaccgacgtgggcagtgtccgcatgcggagggcagagaagtcc
gtggcccccagcaacacagggagcaggaccaccagtgtccgctgcagaggtatcccccgg
ggacctgtgaggccagccatcccaccaccactgtcgtcagtgtatgcctggggtggtggg
ctgggcacccccctgcggctgccaatgctcaacacagaggtggtccaggtggcagctggg
cgcacgcagaaagccggcgtcacgcgctctgggcgtctcatcctgtgggaggccccaccc
ctaggtgcaggcggaggcagtctccttcctggggcagtggagcagccacagccccagttc
atctcgcgtttcctggagggccagtcgggtgtgaccatcaagcacgtggcctgtggggac
ttcttcactgcctgcctgactgacagaggcatcatcatgacattcggcagcggcagcaat
gggtgcctaggccatggcagcctcactgacatcagccagcccaccattgtggaggctttg
ctgggctatgaaatggtgcaggtggcctgtggggcctctcacgtgctggccctgtccact
gagcgagaactatttgcctggggccgtggagacagcggcagactggggctaggcaccagg
gagtcccacagctgcccccagcaggtgcccatgcccccaggacaggaagctcagcgagtt
gtatgtggtatcgattcctccatgatcctcactgtgcctggccaagccctagcctgtggg
agcaacaggttcaacaagctgggcctggaccacctctccctgggggaggagcctgtcccc
caccagcaagtggaggaggccctgagcttcacactactaggctctgcacccctggaccag
gagcctctgctgagtatagacctgggcactgctcactcagctgctgtgactgcctcgggt
gattgctacacttttggcagcaatcagcacggacagttgggcaccaatactcgccgaggc
agtcgggcaccctgtaaggtccaaggccttgagggcatcaagatggcaatggtagcctgt
ggggatgccttcactgtagctattggggcagagagcgaagtgtactcttggggcaaaggg
gcgcgaggtcgattgggaaggagggatgaggatgccggactccctcggccagtgcagttg
gatgagacacacccttacacggtgacttccgtgtcctgttgccatggaaacaccctcctg
gctgttcgatcggtcacagatgagccggtccccccctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (6)   
   Pfam (6)   
All databases (51)   

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