KEGG   Homo sapiens (human): 286204
Entry
286204            CDS       T01001                                 
Symbol
CRB2, FSGS9, VMCKD
Name
(RefSeq) crumbs cell polarity complex component 2
  KO
K16681  protein crumbs
Organism
hsa  Homo sapiens (human)
Pathway
hsa04390  Hippo signaling pathway
Disease
H00626  Focal segmental glomerulosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    286204 (CRB2)
SSDB
Motif
Pfam: EGF hEGF Laminin_G_2 Laminin_G_1 EGF_CA EGF_3 EGF_2 JAG1-like_EGF2
Other DBs
NCBI-GeneID: 286204
NCBI-ProteinID: NP_775960
OMIM: 609720
HGNC: 18688
Ensembl: ENSG00000148204
UniProt: Q5IJ48
Structure
Position
9:123354065..123380326
AA seq 1285 aa
MALARPGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGG
YTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHG
ATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTR
CQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLE
GLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRH
AAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVD
ECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVH
SYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDT
KESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGC
PARLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVL
LGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASF
LLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGR
WDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFF
PLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGP
TCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAF
RTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVR
LAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALG
GLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFAC
ACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSL
NVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICN
ARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSP
SQQEVAGARLEMDSVLKVPPEERLI
NT seq 3858 nt   +upstreamnt  +downstreamnt
atggcgctggccaggcctgggaccccggacccccaggccctggcctctgtcctgctactg
ctgctctgggcccctgccctttccctcctggctgggacggtgccttcagagccccccagt
gcctgtgcctcagacccgtgcgctccagggaccgagtgccaggctaccgagagtggtggc
tatacctgtgggcccatggagccccggggctgtgccacccagccatgccaccacggcgct
ctgtgtgtgccccagggtccagatcccaccggcttccgctgctactgcgtgccgggtttc
cagggcccacgctgcgagctggacatcgatgagtgtgcatcccggccgtgccaccatggg
gccacctgccgcaacctggccgatcgctacgagtgccattgcccccttggctatgcaggc
gtgacctgcgagatggaggtggacgagtgcgcctcagcgccctgcctgcacgggggctcg
tgcctggacggcgtgggctccttccgctgtgtgtgcgcgccaggctacgggggcacccgt
tgccagctggacctcgacgagtgccagagccagccgtgcgcacatgggggcacgtgccac
gacctggtcaacgggttccggtgcgactgcgcgggcaccggctacgagggcacgcactgc
gagcgggaggtgctggagtgcgcatcggcgccctgcgagcacaacgcgtcctgcctcgag
ggcctcgggagcttccgctgcctctgttggccaggctacagcggcgagctgtgcgaggtg
gacgaggacgagtgtgcatcgagcccctgccagcatgggggccgatgcctgcagcgctct
gacccggccctctacgggggtgtccaggccgccttccctggcgccttcagcttccgccat
gctgcgggtttcctgtgccactgccctcctggctttgagggagccgactgcggtgtggag
gtggacgagtgtgcctcacggccatgcctcaacggaggccactgccaggacctgcccaat
ggcttccagtgtcactgcccagatggctacgcagggccgacatgtgaggaagatgtggat
gaatgcctgtcggatccctgcctgcacggcggaacctgcagtgacactgtggcaggctat
atctgcaggtgcccagagacctggggtgggcgcgactgttctgtgcagctcactggctgc
cagggccacacctgcccgctggctgccacctgcatccctatcttcgagtctggggtccac
agttacgtctgccactgcccacctggtacccatggaccgttctgtggccagaataccacc
ttctctgtgatggctgggagccccattcaggcatcagtgccagctggtggccccctgggt
ctggcactgaggtttcgcaccacactgcccgctgggaccttggccactcgcaatgacacc
aaggaaagcttggagctggcattggtggcagccacacttcaggccacactctggagctac
agcaccactgtgcttgtcctgagactgccggacctggccctaaacgatggccattggcac
caggtggaggttgtgctccatctagcgaccctggagctacggctctggcatgagggctgc
cctgcccggctctgtgtggcctctggtcctgtggccctggcttccacggcttcggcaact
ccgctgcctgccgggatctcctctgcccagctgggggacgcgacctttgcaggctgcctc
caggacgtgcgtgtggatggccacctcctgctgcctgaggatctcggtgagaacgtcctc
ctgggctgtgagcgccgagagcagtgccggcctctgccttgtgtccacggagggtcctgt
gtggatctgtggactcatttccgttgcgactgtgcccggccccatagaggtcccacgtgc
gctgatgagattcctgctgccacctttggcttgggaggcgccccaagctctgcctccttt
ctgctccaagagctgccaggtcccaacctcacagtgtctttccttctccgcactcgggag
tccgctggcctgttgctccagtttgccaatgactccgcagctggcctaacagtattcctg
agtgagggtcggatccgggctgaggtgccgggcagtcctgctgtagtgctccctgggcgc
tgggatgatgggctccgtcacctggtgatgctcagcttcgggcctgaccagctgcaggac
ctggggcagcacgtgcacgtgggtgggaggctccttgctgccgacagccagccctggggt
gggcccttccgaggctgcctccaggacctgcgactcgatggctgccacctccccttcttt
cctctgccactggataactcaagccagcccagcgagctcggcggcaggcagtcctggaac
ctcactgcgggctgcgtctccgaggacatgtgcagtcctgacccctgtttcaatggtggg
acttgcctcgtcacctggaatgacttccactgtacctgccctgccaatttcacggggcct
acgtgtgcccagcagctgtggtgtcccggccagccctgtctcccacctgccacgtgtgag
gaggtccctgatggctttgtgtgtgtggcggaggccacgttccgcgagggtccccccgcc
gcgttcagcgggcacaacgcgtcgtcagggcgcttgctcggcggcctgtcgctggccttt
cgcacgcgcgactccgaggcctggctgctgcgtgccgcggcgggcgccctggaaggcgtg
tggctggcggtgcgcaatggctcgctggcggggggcgtgcgcggaggccatggcctgccc
ggcgctgtgctgcccataccggggccgcgcgtggccgatggtgcctggcaccgcgtgcgt
ctggccatggagcgcccggcggccaccacctcgcgctggctgctgtggctggatggtgcc
gccaccccggtggcgctgcgcggcctggccagtgacctgggcttcctgcagggcccgggt
gctgtgcgcatcctgctggctgagaacttcaccggctgcttgggccgcgtggcgctgggc
ggcctgcccctgcccttggcgcggccccggcccggcgcggcccctggcgcccgagagcac
ttcgcgtcttggcctgggacgccggccccgatcctcggctgccgcggcgcgcccgtgtgt
gcgccctcgccctgtctgcacgacggtgcctgccgtgacctcttcgacgcctttgcctgc
gcctgcggcccggggtgggaaggcccgcgctgcgaagcccacgtcgacccctgtcactcc
gccccctgcgcccgtggccgctgtcacacgcaccccgacggccgcttcgagtgccgctgc
ccgcctggcttcgggggcccgcgctgcaggttgcctgtcccatccaaggagtgcagcctg
aatgtcacctgcctcgatggcagcccatgtgagggtggctctcccgctgccaactgcagc
tgcctggagggtcttgctggccagaggtgtcaggtccccactctcccctgtgaagccaac
ccctgcttgaatgggggcacctgccgggcagctggaggggtgtctgaatgtatctgcaat
gccagattctccggccagttctgtgaagtggcgaagggcctgcccctgccgctgccattc
ccactgctggaggtggccgtacctgcagcctgtgcctgcctcctcctcctcctcctgggc
ctcctttcagggatcctggcagcccgaaagcgccgccagtctgagggcacctacagccca
agccagcaggaggtggctggggcccggctggagatggacagtgtcctcaaggtgccaccg
gaggagagactcatctag

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (66)   
   KEGG ORTHOLOGY (1)   
   RefGene (60)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (29)   
   RefSeq(nuc) (13)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (125)   

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