KEGG   Homo sapiens (human): 2870
Entry
2870              CDS       T01001                                 
Symbol
GRK6, GPRK6
Name
(RefSeq) G protein-coupled receptor kinase 6
  KO
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    2870 (GRK6)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2870 (GRK6)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2870 (GRK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2870 (GRK6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     2870 (GRK6)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   2870 (GRK6)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RGS Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 2870
NCBI-ProteinID: NP_001004106
OMIM: 600869
HGNC: 4545
Ensembl: ENSG00000198055
UniProt: P43250
Structure
Position
5:177425523..177442891
AA seq 576 aa
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
NT seq 1731 nt   +upstreamnt  +downstreamnt
atggagctcgagaacatcgtagcgaacacggtgctactcaaggcccgggaaggtggcggt
ggaaatcgcaaaggcaaaagcaagaaatggcggcagatgctccagttccctcacatcagc
cagtgcgaagagctgcggctcagcctcgagcgtgactatcacagcctgtgcgagcggcag
cccattgggcgcctgctgttccgagagttctgtgccacgaggccggagctgagccgctgc
gtcgccttcctggatggggtggccgagtatgaagtgaccccggatgacaagcggaaggca
tgtgggcggcagctaacgcagaattttctgagccacacgggtcctgacctcatccctgag
gtcccccggcagctggtgacgaactgcacccagcggctggagcagggtccctgcaaagac
cttttccaggaactcacccggctgacccacgagtacctgagcgtggccccttttgccgac
tacctcgacagcatctacttcaaccgtttcctgcagtggaagtggctggaaaggcagcca
gtgaccaaaaacaccttcaggcaataccgagtcctgggcaaaggtggctttggggaggtg
tgcgcctgccaggtgcgggccacaggtaagatgtatgcctgcaagaagctagagaaaaag
cggatcaagaagcggaaaggggaggccatggcgctgaacgagaagcagatcctggagaaa
gtgaacagtaggtttgtagtgagcttggcctacgcctatgagaccaaggacgcgctgtgc
ctggtgctgacactgatgaacgggggcgacctcaagttccacatctaccacatgggccag
gctggcttccccgaagcgcgggccgtcttctacgccgccgagatctgctgtggcctggag
gacctgcaccgggagcgcatcgtgtacagggacctgaagcccgagaacatcttgctggat
gaccacggccacatccgcatctctgacctgggactagctgtgcatgtgcccgagggccag
accatcaaagggcgtgtgggcaccgtgggttacatggctccggaggtggtgaagaatgaa
cggtacacgttcagccctgactggtgggcgctcggctgcctcctgtacgagatgatcgca
ggccagtcgcccttccagcagaggaagaagaagatcaagcgggaggaggtggagcggctg
gtgaaggaggtccccgaggagtattccgagcgcttttccccgcaggcccgctcactttgc
tcacagctcctctgcaaggaccctgccgaacgcctggggtgtcgtgggggcagtgcccgc
gaggtgaaggagcaccccctctttaagaagctgaacttcaagcggctgggagctggcatg
ctggagccgccgttcaagcctgacccccaggccatttactgcaaggatgttctggacatt
gaacagttctctacggtcaagggcgtggagctggagcctaccgaccaggacttctaccag
aagtttgccacaggcagtgtgcccatcccctggcagaacgagatggtggagaccgagtgc
ttccaagagctgaatgtctttgggctggatggctcagttcccccagacctggactggaag
ggccagccacctgcacctcctaaaaagggactgctgcagagactcttcagtcgccaagat
tgctgtggaaactgcagcgacagcgaggaagagctccccacccgcctctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (32)   
   RefSeq(nuc) (12)   
   GenBank (10)   
   EMBL (10)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (78)   

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