KEGG   Homo sapiens (human): 29126
Entry
29126             CDS       T01001                                 
Symbol
CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1
Name
(RefSeq) CD274 molecule
  KO
K06745  programmed cell death 1 ligand 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
Drug target
Atezolizumab: D10773<JP/US>
Avelumab: D10817<JP/US>
Bintrafusp alfa: D11893
Cosibelimab: D11946
Danburstotug: D12349
Durvalumab: D10808<JP/US>
Enristomig: D12561
Inbakicept: D11747
Lodapolimab: D11532
Pimivalimab: D12143
Socazolimab: D12344
Sugemalimab: D12750
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    29126 (CD274)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    29126 (CD274)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    29126 (CD274)
CD molecules [BR:hsa04090]
 Proteins
  29126 (CD274)
SSDB
Motif
Pfam: Ig_3 C2-set_2 ig I-set V-set Ig_2 C1-set Lep_receptor_Ig aBig_2
Other DBs
NCBI-GeneID: 29126
NCBI-ProteinID: NP_054862
OMIM: 605402
HGNC: 17635
Ensembl: ENSG00000120217
UniProt: Q9NZQ7
Structure
Position
9:5450542..5470554
AA seq 290 aa
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
NT seq 873 nt   +upstreamnt  +downstreamnt
atgaggatatttgctgtctttatattcatgacctactggcatttgctgaacgcatttact
gtcacggttcccaaggacctatatgtggtagagtatggtagcaatatgacaattgaatgc
aaattcccagtagaaaaacaattagacctggctgcactaattgtctattgggaaatggag
gataagaacattattcaatttgtgcatggagaggaagacctgaaggttcagcatagtagc
tacagacagagggcccggctgttgaaggaccagctctccctgggaaatgctgcacttcag
atcacagatgtgaaattgcaggatgcaggggtgtaccgctgcatgatcagctatggtggt
gccgactacaagcgaattactgtgaaagtcaatgccccatacaacaaaatcaaccaaaga
attttggttgtggatccagtcacctctgaacatgaactgacatgtcaggctgagggctac
cccaaggccgaagtcatctggacaagcagtgaccatcaagtcctgagtggtaagaccacc
accaccaattccaagagagaggagaagcttttcaatgtgaccagcacactgagaatcaac
acaacaactaatgagattttctactgcacttttaggagattagatcctgaggaaaaccat
acagctgaattggtcatcccagaactacctctggcacatcctccaaatgaaaggactcac
ttggtaattctgggagccatcttattatgccttggtgtagcactgacattcatcttccgt
ttaagaaaagggagaatgatggatgtgaaaaaatgtggcatccaagatacaaactcaaag
aagcaaagtgatacacatttggaggagacgtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (12)   
   KEGG DRUG (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (40)   
   RefSeq(nuc) (6)   
   GenBank (17)   
   EMBL (17)   
3D Structure (57)   
   PDB (57)   
Protein domain (9)   
   Pfam (9)   
All databases (143)   

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