KEGG   Homo sapiens (human): 2937
Entry
2937              CDS       T01001                                 
Symbol
GSS, GSHS, HEL-S-64p, HEL-S-88n
Name
(RefSeq) glutathione synthetase
  KO
K21456  glutathione synthase [EC:6.3.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04216  Ferroptosis
Module
hsa_M00118  Glutathione biosynthesis, glutamate => glutathione
Network
nt06026  Glutathione biosynthesis
nt06525  Ferroptosis
  Element
N01589  Glutathione biosynthesis
Disease
H00668  Anemia due to disorders of glutathione metabolism
H02312  Glutathione synthetase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    2937 (GSS)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2937 (GSS)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    2937 (GSS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2937 (GSS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.3  glutathione synthase
     2937 (GSS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2937 (GSS)
SSDB
Motif
Pfam: GSH_synth_ATP GSH_synthase
Other DBs
NCBI-GeneID: 2937
NCBI-ProteinID: NP_000169
OMIM: 601002
HGNC: 4624
Ensembl: ENSG00000100983
UniProt: P48637 V9HWJ1
Structure
Position
20:complement(34928432..34956027)
AA seq 474 aa
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSA
LLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVF
LGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFE
DISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQ
LAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSR
FVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVV
QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
NT seq 1425 nt   +upstreamnt  +downstreamnt
atggccaccaactgggggagcctcttgcaggataaacagcagctagaggagctggcacgg
caggccgtggaccgggccctggctgagggagtattgctgaggacctcacaggagcccact
tcctcggaggtggtgagctatgccccattcacgctcttcccctcactggtccccagtgcc
ctgctggagcaagcctatgctgtgcagatggacttcaacctgctagtggatgctgtcagc
cagaacgctgccttcctggagcaaactctttccagcaccatcaaacaggatgactttacc
gctcgtctctttgacatccacaagcaagtcctaaaagagggcattgcccagactgtgttc
ctgggcctgaatcgctcagactacatgttccagcgcagcgcagatggctccccagccctg
aaacagatcgaaatcaacaccatctctgccagctttgggggcctggcctcccggacccca
gctgtgcaccgacatgttctcagtgtcctgagtaagaccaaagaagctggcaagatcctc
tctaataatcccagcaagggactggccctgggaattgccaaagcctgggagctctacggc
tcacccaatgctctggtgctactgattgctcaagagaaggaaagaaacatatttgaccag
cgtgccatagagaatgagctactggccaggaacatccatgtgatccgacgaacatttgaa
gatatctctgaaaaggggtctctggaccaagaccgaaggctgtttgtggatggccaggaa
attgctgtggtttacttccgggatggctacatgcctcgtcagtacagtctacagaattgg
gaagcacgtctactgctggagaggtcacatgctgccaagtgcccagacattgccacccag
ctggctgggactaagaaggtgcagcaggagctaagcaggccgggcatgctggagatgttg
ctccctggccagcctgaggctgtggcccgcctccgcgccacctttgctggcctctactca
ctggatgtgggtgaagaaggggaccaggccatcgccgaggcccttgctgcccctagccgg
tttgtgctaaagccccagagagagggtggaggtaacaacctatatggggaggaaatggta
caggccctgaaacagctgaaggacagtgaggagagggcctcctacatcctcatggagaag
atcgaacctgagccttttgagaattgcctgctacggcctggcagccctgcccgagtggtc
cagtgcatttcagagctgggcatctttggggtctatgtcaggcaggaaaagacactcgtg
atgaacaagcacgtggggcatctacttcgaaccaaagccatcgagcatgcagatggtggt
gtggcagcgggagtggcagtcctggacaacccataccctgtgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (83)   

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