| Entry |
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| Symbol |
GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
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| Name |
(RefSeq) glutathione S-transferase mu 1
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| KO |
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| Organism |
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| Pathway |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00983 | Drug metabolism - other enzymes |
| hsa05204 | Chemical carcinogenesis - DNA adducts |
| hsa05207 | Chemical carcinogenesis - receptor activation |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
| hsa05418 | Fluid shear stress and atherosclerosis |
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| Network |
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| Element |
| N00243 | KEAP1-NRF2 signaling pathway |
| N00244 | Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway |
| N00245 | Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway |
| N01365 | TCDD to Ahr signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09106 Metabolism of other amino acids
00480 Glutathione metabolism
2944 (GSTM1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
2944 (GSTM1)
00982 Drug metabolism - cytochrome P450
2944 (GSTM1)
00983 Drug metabolism - other enzymes
2944 (GSTM1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2944 (GSTM1)
05204 Chemical carcinogenesis - DNA adducts
2944 (GSTM1)
05207 Chemical carcinogenesis - receptor activation
2944 (GSTM1)
05208 Chemical carcinogenesis - reactive oxygen species
2944 (GSTM1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
2944 (GSTM1)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
2944 (GSTM1)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
2944 (GSTM1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:hsa02000]
2944 (GSTM1)
Enzymes [BR:hsa01000]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.18 glutathione transferase
2944 (GSTM1)
Transporters [BR:hsa02000]
Other transporters
Pores ion channels [TC:1]
2944 (GSTM1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
1:109687817..109693745
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| AA seq |
218 aa
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK |
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| NT seq |
657 nt +upstreamnt +downstreamnt
atgcccatgatactggggtactgggacatccgcgggctggcccacgccatccgcctgctc
ctggaatacacagactcaagctatgaggaaaagaagtacacgatgggggacgctcctgat
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatggggctcacaagatcacccagagcaacgccatcttgtgctacatt
gcccgcaagcacaacctgtgtggggagacagaagaggagaagattcgtgtggacattttg
gagaaccagaccatggacaaccatatgcagctgggcatgatctgctacaatccagaattt
gagaaactgaagccaaagtacttggaggaactccctgaaaagctaaagctctactcagag
tttctggggaagcggccatggtttgcaggaaacaagatcacttttgtagattttctcgtc
tatgatgtccttgacctccaccgtatatttgagcccaagtgcttggacgccttcccaaat
ctgaaggacttcatctcccgctttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaagacctgtgttctcaaagatggctgtctggggcaacaagtag |
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