KEGG   Homo sapiens (human): 2984
Entry
2984              CDS       T01001                                 
Symbol
GUCY2C, DIAR6, GC-C, GCC, GUC2C, HSER, MECIL, MUCIL, STAR
Name
(RefSeq) guanylate cyclase 2C
  KO
K12320  heat-stable enterotoxin receptor [EC:4.6.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
Disease
H01174  Congenital diarrhea
H01615  Irritable bowel syndrome
Drug target
Dolcanatide: D11233
Linaclotide (DG00079): D06612 D09355<JP/US>
Plecanatide: D09948<US>
Recanaclotide: D10976
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    2984 (GUCY2C)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2984 (GUCY2C)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     2984 (GUCY2C)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   2984 (GUCY2C)
SSDB
Motif
Pfam: Guanylate_cyc PK_Tyr_Ser-Thr Pkinase ANF_receptor LapA_dom
Other DBs
NCBI-GeneID: 2984
NCBI-ProteinID: NP_004954
OMIM: 601330
HGNC: 4688
Ensembl: ENSG00000070019
UniProt: P25092
Structure
Position
12:complement(14612632..14696599)
AA seq 1073 aa
MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNE
GLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLI
GPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL
PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHN
RKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS
PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF
EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKL
PNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLE
TNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID
YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKG
MSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQK
GDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV
YLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVE
ERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYS
TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEI
LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL
RIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQ
RLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF
NT seq 3222 nt   +upstreamnt  +downstreamnt
atgaagacgttgctgttggacttggctttgtggtcactgctcttccagcccgggtggctg
tcctttagttcccaggtgagtcagaactgccacaatggcagctatgaaatcagcgtcctg
atgatgggcaactcagcctttgcagagcccctgaaaaacttggaagatgcggtgaatgag
gggctggaaatagtgagaggacgtctgcaaaatgctggcctaaatgtgactgtgaacgct
actttcatgtattcggatggtctgattcataactcaggcgactgccggagtagcacctgt
gaaggcctcgacctactcaggaaaatttcaaatgcacaacggatgggctgtgtcctcata
gggccctcatgtacatactccaccttccagatgtaccttgacacagaattgagctacccc
atgatctcagctggaagttttggattgtcatgtgactataaagaaaccttaaccaggctg
atgtctccagctagaaagttgatgtacttcttggttaacttttggaaaaccaacgatctg
cccttcaaaacttattcctggagcacttcgtatgtttacaagaatggtacagaaactgag
gactgtttctggtaccttaatgctctggaggctagcgtttcctatttctcccacgaactc
ggctttaaggtggtgttaagacaagataaggagtttcaggatatcttaatggaccacaac
aggaaaagcaatgtgattattatgtgtggtggtccagagttcctctacaagctgaagggt
gaccgagcagtggctgaagacattgtcattattctagtggatcttttcaatgaccagtac
tttgaggacaatgtcacagcccctgactatatgaaaaatgtccttgttctgacgctgtct
cctgggaattcccttctaaatagctctttctccaggaatctatcaccaacaaaacgagac
tttgctcttgcctatttgaatggaatcctgctctttggacatatgctgaagatatttctt
gaaaatggagaaaatattaccacccccaaatttgctcatgctttcaggaatctcactttt
gaagggtatgacggtccagtgaccttggatgactggggggatgttgacagtaccatggtg
cttctgtatacctctgtggacaccaagaaatacaaggttcttttgacctatgatacccac
gtaaataagacctatcctgtggatatgagccccacattcacttggaagaactctaaactt
cctaatgatattacaggccggggccctcagatcctgatgattgcagtcttcaccctcact
ggagctgtggtgctgctcctgctcgtcgctctcctgatgctcagaaaatatagaaaagat
tatgaacttcgtcagaaaaaatggtcccacattcctcctgaaaatatctttcctctggag
accaatgagaccaatcatgttagcctcaagatcgatgatgacaaaagacgagatacaatc
cagagactacgacagtgcaaatacgacaaaaagcgagtgattctcaaagatctcaagcac
aatgatggtaatttcactgaaaaacagaagatagaattgaacaagttgcttcagattgac
tattacaacctgaccaagttctacggcacagtgaaacttgataccatgatcttcggggtg
atagaatactgtgagagaggatccctccgggaagttttaaatgacacaatttcctaccct
gatggcacattcatggattgggagtttaagatctctgtcttgtatgacattgctaaggga
atgtcatatctgcactccagtaagacagaagtccatggtcgtctgaaatctaccaactgc
gtagtggacagtagaatggtggtgaagatcactgattttggctgcaattccattttacct
ccaaaaaaggacctgtggacagctccagagcacctccgccaagccaacatctctcagaaa
ggagatgtgtacagctatgggatcatcgcacaggagatcatcctgcggaaagaaaccttc
tacactttgagctgtcgggaccggaatgagaagattttcagagtggaaaattccaatgga
atgaaacccttccgcccagatttattcttggaaacagcagaggaaaaagagctagaagtg
tacctacttgtaaaaaactgttgggaggaagatccagaaaagagaccagatttcaaaaaa
attgagactacacttgccaagatatttggactttttcatgaccaaaaaaatgaaagctat
atggataccttgatccgacgtctacagctatattctcgaaacctggaacatctggtagag
gaaaggacacagctgtacaaggcagagagggacagggctgacagacttaactttatgttg
cttccaaggctagtggtaaagtctctgaaggagaaaggctttgtggagccggaactatat
gaggaagttacaatctacttcagtgacattgtaggtttcactactatctgcaaatacagc
acccccatggaagtggtggacatgcttaatgacatctataagagttttgaccacattgtt
gatcatcatgatgtctacaaggtggaaaccatcggtgatgcgtacatggtggctagtggt
ttgcctaagagaaatggcaatcggcatgcaatagacattgccaagatggccttggaaatc
ctcagcttcatggggacctttgagctggagcatcttcctggcctcccaatatggattcgc
attggagttcactctggtccctgtgctgctggagttgtgggaatcaagatgcctcgttat
tgtctatttggagatacggtcaacacagcctctaggatggaatccactggcctccctttg
agaattcacgtgagtggctccaccatagccatcctgaagagaactgagtgccagttcctt
tatgaagtgagaggagaaacatacttaaagggaagaggaaatgagactacctactggctg
actgggatgaaggaccagaaattcaacctgccaacccctcctactgtggagaatcaacag
cgtttgcaagcagaattttcagacatgattgccaactctttacagaaaagacaggcagca
gggataagaagccaaaaacccagacgggtagccagctataaaaaaggcactctggaatac
ttgcagctgaataccacagacaaggagagcacctatttttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (5)   
   KEGG DRUG (5)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (15)   
   RefSeq(nuc) (3)   
   GenBank (6)   
   EMBL (6)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (63)   

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