KEGG   Homo sapiens (human): 29953
Entry
29953             CDS       T01001                                 
Symbol
TRHDE, PAP-II, PGPEP2, TRH-DE
Name
(RefSeq) thyrotropin releasing hormone degrading enzyme
  KO
K01306  pyroglutamyl-peptidase II [EC:3.4.19.6]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    29953 (TRHDE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.6  pyroglutamyl-peptidase II
     29953 (TRHDE)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   29953 (TRHDE)
SSDB
Motif
Pfam: Peptidase_M1 ERAP1_C Peptidase_M1_N Ferlin_C
Other DBs
NCBI-GeneID: 29953
NCBI-ProteinID: NP_037513
OMIM: 606950
HGNC: 30748
Ensembl: ENSG00000072657
UniProt: Q9UKU6
Position
12:72087266..72670758
AA seq 1069 aa
MALDGELGEQEEEKKKKKKKKRKKKKEEEEEEEGAEKSSSPFAAAMGEDDAALRAGSRGL
SDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPG
ADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEP
WTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLA
EDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVL
HGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDG
WVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKR
LIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVT
MVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHE
VMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLT
IHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIIT
QQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDK
GSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQ
NIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWP
KNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDI
VYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL
DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL
KELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGKALRH
NT seq 3210 nt   +upstreamnt  +downstreamnt
atggccctggacggcgagctgggggagcaagaggaggagaagaaaaagaagaagaaaaag
aagaggaagaagaagaaggaggaggaggaggaggaggagggggccgagaagagcagctca
cccttcgcagccgcgatgggggaagacgacgccgcgcttcgggctggcagcagggggctc
tccgacccgtgggcagactcagtgggagtgcgaccccgcaccacggagcgccacatcgcc
gtacacaagcggcttgtgctggccttcgctgtgtccctcgtggcattgctcgcggtcaca
atgctcgctgtgctgctcagcctgcgcttcgacgagtgcggggcgagtgccacgccaggc
gccgacggtggcccctcaggctttccggagcgcggcggcaacgggagcctccctggatcg
gcccggcgcaaccaccacgcaggcggggactcctggcagcccgaggcgggtggggtggcc
agtccggggaccacgtcggcccagccgccgtcggaggaggagcgggagccgtgggagccg
tggacgcagctgcgcctgtcgggccacctgaagccgctgcactacaatctgatgctcacc
gccttcatggagaacttcaccttctccggggaggtcaacgtggagatcgcgtgccggaac
gccacccgctacgtagtgctgcacgcttcccgagtggcggtggagaaagtgcagctggcc
gaggaccgggcgttcggggctgtccctgtagccggttttttcctctacccgcaaacccag
gtcttagtggtggtgctgaataggacactggacgcgcagaggaattacaatctgaagatt
atctacaacgcgctcatcgagaatgagctcctgggcttcttccgcagctcctatgtgctc
cacggggagagaagattccttggtgttactcagttttcgcctacacatgccagaaaggca
tttccttgttttgatgagccaatctacaaggctactttcaaaatcagcatcaagcatcaa
gcaacctatttatctttatctaatatgccagtggaaacttccgtgtttgaggaagatgga
tgggttacggatcacttttcacagacccctctcatgtccacatattatttagcctgggca
atttgcaacttcacatacagagaaactaccaccaagagtggggttgtagtacgattatat
gcaagacctgatgctatcagaagaggatccggggactatgctctccatataacaaagaga
ttaatagaattttatgaagactactttaaagtgccctattccttgccaaaactagatctt
ttagctgtgcctaagcatccgtatgctgctatggagaactggggactaagtatttttgtg
gaacaaagaatactgctggatcccagtgtttcatctatttcttatttgctggatgtcacc
atggtcattgttcatgagatatgtcaccagtggtttggtgaccttgtgacgcctgtgtgg
tgggaagacgtgtggctgaaggaagggtttgctcactactttgaatttgttggtacagac
tacctctatcctggctggaacatggaaaagcagaggtttctgaccgatgttctgcatgaa
gtgatgctgctggacggtttggccagttcccatccagtatcacaggaagtgctgcaggca
acagatattgacagggtgtttgactggatcgcatataaaaagggtgctgctttaataaga
atgctggctaattttatgggccattcagttttccagaggggtttgcaagattatttaacc
attcataagtatggtaatgcagccagaaatgatctctggaatacattatcggaggcttta
aaaagaaatgggaaatatgtaaatatacaagaagtaatggatcagtggacactccagatg
ggttatcctgttatcaccatcttgggaaacacaacagcagaaaatagaataataattacc
caacagcattttatctatgatatcagtgctaaaactaaagcacttaaacttcagaataac
agttacctgtggcagattccattaactattgtggtaggaaatagaagccatgtgtcttca
gaagcaattatttgggtgtctaacaaatcagagcaccacagaataacttatttggacaaa
ggaagctggctgctggggaacatcaatcaaactggctattttagagtcaactatgaccta
aggaactggagattattaattgatcaattaatccggaatcatgaggttctttctgtcagt
aaccgagcgggcttgatcgatgatgccttcagcctagccagggctggctatttgcctcag
aatattcctctggagattatcagatacctgtctgaggagaaggattttcttccttggcat
gctgccagccgagctctttatcctctagataaattactggaccgcatggaaaactacaac
attttcaatgaatatattttaaagcaagttgcaacaacatatatcaagcttgggtggccg
aaaaataattttaatggatctcttgttcaagcatcctaccaacatgaagaactacgtaga
gaagttataatgctggcctgcagttttggcaacaagcactgtcaccaacaggcatcaaca
cttatttcagattggatttccagcaacaggaacagaataccactaaatgttagagacatc
gtatactgtacaggagtgtcactactggatgaggatgtctgggaattcatatggatgaaa
ttccattccaccacagcagtttctgagaagaaaatattattggaagccttaacttgcagt
gatgacaggaatttattaaacaggcttctaaatctgtcactgaattctgaggtggtgctg
gatcaagatgcaattgatgtcataatccatgtagctcgaaatccacatggtcgagacctt
gcctggaagtttttcagggataaatggaagatattaaataccaggtatggagaagcattg
tttatgaattccaaactcatcagtggtgtcacagaatttcttaatactgaaggtgaactc
aaagagctcaagaacttcatgaaaaactatgatggggtagctgctgcttctttctcacga
gctgtggaaactgtcgaagccaatgtgcgctggaaaatgctttaccaagacgagcttttc
caatggttaggaaaagctctaagacactaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (21)   
   RefSeq(nuc) (9)   
   GenBank (6)   
   EMBL (6)   
Protein domain (4)   
   Pfam (4)   
All databases (54)   

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