KEGG   Homo sapiens (human): 3054
Entry
3054              CDS       T01001                                 
Symbol
HCFC1, CFF, HCF, HCF-1, HCF1, HFC1, MAHCX, MRX3, PPP1R89, VCAF, XLID3
Name
(RefSeq) host cell factor C1
  KO
K14966  host cell factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04980  Cobalamin transport and metabolism
hsa05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06523  Epigenetic regulation by Polycomb complexes
nt06538  Cobalamin transport and metabolism
  Element
N00588  HSV VP16 to Oct-1-mediated transcription
N01585  Deubiquitination of H2AK119
N01810  Regulation of MMACHC expression
Disease
H00174  Methylmalonic aciduria
H00480  X-linked intellectual developmental disorder
H02222  Methylmalonic acidemia and hyperhomocysteinemia, cblX type
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    3054 (HCFC1)
 09150 Organismal Systems
  09154 Digestive system
   04980 Cobalamin transport and metabolism
    3054 (HCFC1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    3054 (HCFC1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3054 (HCFC1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3054 (HCFC1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3054 (HCFC1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     3054 (HCFC1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    NSL complex
     3054 (HCFC1)
   HMT complexes
    COMPASS/SET1 complex
     3054 (HCFC1)
    MLL-HCF complex
     3054 (HCFC1)
   Polycomb repressive complex (PRC) and associated proteins
    PR-DUB complex
     3054 (HCFC1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    3054 (HCFC1)
SSDB
Motif
Pfam: Kelch_5 Kelch_3 Kelch_1 Kelch_4 Kelch_6 Kelch_2 fn3
Other DBs
NCBI-GeneID: 3054
NCBI-ProteinID: NP_005325
OMIM: 300019
HGNC: 4839
Ensembl: ENSG00000172534
UniProt: P51610
Structure
Position
X:complement(153947557..153971818)
AA seq 2035 aa
MASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELH
VYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEW
KRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRP
GSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTL
TWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLN
LDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLE
TEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSV
PANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAART
QGVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSS
PQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPV
MVSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKT
ITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGT
ILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQ
AGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPG
QPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGGH
STSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQV
TLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCET
HETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSTVGQQNGSVVRVCSNPPC
ETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTNTATTAMSSVGANHQRDARRACA
AGTPAVIRISVATGALEAAQGSKSQCQTRQTSATSTTMTVMATGAPCSAGPLLGPSMARE
PGGRSPAFVQLAPLSSKVRLSSPSIKDLPAGRHSHAVSTAAMTRSSVGAGEPRMAPVCES
LQGGSPSTTVTVTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNP
PCETHETGTTHTATTATSNGGTGQPEGGQQPPAGRPCETHQTTSTGTTMSVSVGALLPDA
TSSHRTVESGLEVAAAPSVTPQAGTALLAPFPTQRVCSNPPCETHETGTTHTATTVTSNM
SSNQDPPPAASDQGEVESTQGDSVNITSSSAITTTVSSTLTRAVTTVTQSTPVPGPSVPP
PEELQVSPGPRQQLPPRQLLQSASTALMGESAEVLSASQTPELPAAVDLSSTGEPSSGQE
SAGSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEA
AAQAAATEEAQALAIQAVLQAAQQAVMGTGEPMDTSEAAATVTQAELGHLSAEGQEGQAT
TIPIVLTQQELAALVQQQQLQEAQAQQQHHHLPTEALAPADSLNDPAIESNCLNELAGTV
PSTVALLPSTATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPP
PSKAPMKKENQWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDLGTVPDYNQLKKQELQPGT
AYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKI
IEYSVYLAIQSSQAGGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAII
FRIAARNEKGYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSAPKKSKADGQ
NT seq 6108 nt   +upstreamnt  +downstreamnt
atggcttcggccgtgtcgcccgccaacttgccagcggtgcttctgcagccccgctggaag
cgagtggtgggctggtcgggtccggtgccacggccccgccacggccaccgcgccgtggcc
atcaaggagctcatcgtggtgtttggcggcggcaacgagggaatagtggacgaactgcac
gtgtacaacacggcaaccaaccagtggttcatcccagccgtgaggggggacattccccct
gggtgtgcagcctatggcttcgtgtgtgacgggactcgcctcctggtgtttggtgggatg
gtggagtatgggaaatacagcaatgacctctacgaactccaggcgagccggtgggagtgg
aagagactcaaagcaaagacgcccaaaaacgggccccctccgtgtcctcgactcgggcac
agcttctcccttgtgggcaacaaatgctacctgtttgggggtctggccaatgatagcgag
gacccaaagaacaacattccaaggtacctgaatgacttatatatcctggaattacggcca
ggctctggagtggtagcctgggacattcccatcacttacggggtcctaccaccaccccgg
gagtcacatactgccgtggtctacaccgaaaaagacaataagaagtccaagctggtgatc
tacggcgggatgagtggctgcaggctgggggacctgtggaccctagatattgacaccctg
acgtggaataagcccagtctcagcggggtggcgcctcttcctcgcagtctccactcggca
accaccatcggaaataaaatgtacgtgtttggtggctgggtgcctctcgtcatggatgac
gtcaaagtggccacacacgagaaggagtggaagtgtaccaacacgctggcttgtctcaac
ctggataccatggcctgggagaccatcctgatggatacactggaggacaacatcccccgt
gctcgggctggccactgcgcagtcgccatcaacacccgcctgtacatttggagtgggcgt
gacggctaccgcaaggcctggaacaaccaggtctgctgcaaggacctctggtacctagag
acagaaaagccaccacccccagcccgagtacaactggtacgcgccaacaccaactccctg
gaggtgagctggggggcagtggcaacagccgacagctaccttctccagctccagaaatat
gacattcctgccacggctgctactgccacctcccctacacccaatccggtcccatctgtg
cctgccaaccctcccaagagccctgccccagcagcagccgcacctgctgtgcagccgctg
acccaagtaggcatcacgctcctgccccaggctgcccccgcacccccgaccaccaccacc
atccaggtcttgccaacggtgcctggcagctccatttctgtgcccaccgcagccaggact
caaggtgtccctgctgttctcaaagtgaccggtcctcaggctacaacaggaactccattg
gtcaccatgcgacctgccagccaggctgggaaagcccctgtcaccgtgacctcccttccc
gccggagtgcggatggttgtgccaacacagagtgcccagggaacggtgattggcagtagc
ccacagatgagtgggatggccgcactggccgctgcggccgctgccacccagaagatcccc
ccttcctcggcacccacggtgctgagtgtcccagcgggtaccaccatcgtgaagaccatg
gctgtgacacctggcactaccaccctcccagccactgtgaaggtggcctcctcgccagtc
atggtgagcaaccctgccactcgcatgctgaagactgcagccgcccaggtggggacatcg
gtttcctccgccaccaacacgtctacccgccctatcatcacagtgcacaagtcaggcact
gtgacagtggcccagcaagcccaggtggtgaccacagttgtgggcggggtcaccaagacc
atcaccctggtgaagagccccatctctgtcccaggaggcagtgctctgatttccaatctg
ggcaaagtgatgtcggtggtccagaccaaaccagttcagacttcagcagtcacaggccag
gcgtccacgggtcctgtgactcagatcatccagaccaaagggcccctgccagcgggaaca
atcctgaagctggtgacctcagcagatggcaagcccaccaccatcatcactaccacgcag
gccagtggggcggggaccaagcccaccatcctgggcatcagcagcgtctcccccagtacc
accaagcccggcacgaccaccatcatcaaaaccatccccatgtcggccatcatcacccag
gcgggcgccacgggtgtgaccagcagtcctggcatcaagtcccccatcaccatcatcacc
accaaggtgatgacttcaggaactggagcacctgcgaaaatcatcactgctgtccccaaa
attgccactggccacgggcagcagggagtgacccaggtggtgcttaagggggccccggga
cagccaggcaccatcctccgcactgtgcccatggggggtgttcgcctggtcacacccgtc
accgtctccgccgtcaagccagccgtcaccacgttggttgtgaaaggcaccacaggtgtc
acgaccctaggcacagtgacaggcaccgtctccaccagccttgccggggcggggggccac
agcactagtgcttccctggccacgcccatcaccaccttgggcaccattgccaccctctca
agccaggtgatcaaccccactgccatcactgtgtcggccgcacagaccacgctgacagcg
gcaggcgggctcacaaccccaaccatcaccatgcagcccgtgtcccagcccacccaggta
actctgatcacggcacctagtggggtggaggcccagcctgtgcatgacctccctgtgtcc
attctggcctccccgactacagaacagcccaccgccacagttaccatcgccgactcaggc
cagggtgatgtgcagcctggcactgtcaccttggtgtgctccaacccaccctgtgagacc
cacgagactggcaccaccaacacggccaccactactgttgtggctaaccttgggggacac
ccccagcccacccaagtgcagttcgtctgtgacagacaggaggcagctgcttctcttgtg
acctcgactgtgggccagcagaatggtagcgtggtccgagtctgttcgaacccgccctgc
gagacccacgagacgggcaccaccaacaccgccaccaccgccacctccaacatggccggg
cagcatggctgctcaaacccaccctgcgagacccacgagacgggcaccaccaacactgcc
actacagccatgtcgagcgtcggcgccaaccaccagcgagatgcccgtcgggcctgtgca
gctggcacccctgccgtgatccggatcagtgtggccactggggcgctggaggcagcccag
ggctctaagtcccagtgccaaacccgccagaccagcgcgaccagcaccaccatgactgtg
atggccaccggggccccgtgctcggccggcccactccttgggccgagcatggcacgggag
cccgggggccgcagccctgcttttgtgcagttggcccctctgagcagcaaagtcaggctg
agcagcccaagcattaaggaccttcctgcggggcgccacagccatgcggtcagcaccgct
gccatgacccgttccagcgtgggtgctggggagccccgcatggcacctgtgtgcgagagc
ctccagggtggctcgcccagcaccacagtgactgtgacagccctggaggcactgctgtgc
ccctcggccaccgtgacccaagtctgctccaacccaccatgtgagacccacgagacaggc
accaccaacaccgccactacctcgaatgcaggcagcgcccagagggtgtgctccaacccg
ccatgcgagacccacgagacgggcaccacccacacggccaccaccgctacttcaaacggg
ggcacgggccagcccgagggtgggcagcagccccctgctggtcgcccctgtgagacacac
cagaccacttccactggcaccaccatgtcggtcagcgtgggtgccctgcttcccgacgcc
acttcttcccacaggaccgtggagtctggcctagaggtggcggcggcacccagcgtcacc
ccccaggctggcaccgcgctgctggctcctttcccaacacagagggtgtgctccaacccc
ccctgtgagacccacgagacgggcaccactcacacggccaccactgtcacttccaacatg
agttcaaaccaagaccccccacctgctgccagcgatcagggagaggtggagagcacccag
ggcgacagcgtgaacatcaccagctccagtgccatcacgacaaccgtgtcctccacactg
acgcgggctgtgaccaccgtgacgcagtccacaccggtcccgggcccctctgtgccgccc
ccagaggaactccaggtgtcgccaggtcctcgccagcagctgccgccacggcagcttctg
cagtcggcttccacagccctgatgggggagtccgccgaggtcctgtcagcctcccagacc
cctgagctcccggccgccgtggatctgagcagcacaggggagccatcttcgggccaggag
tctgccggctctgcggtggtggccactgtggtggtccagccacccccacccacacagtcc
gaagtagaccagttatcacttccccaagagctaatggccgaggcccaagctggcaccacc
accctcatggtaacggggctcacccccgaggagctggcagtgacggctgctgcagaagca
gctgcccaggccgcagccacggaggaagcccaggccctggccatccaggcggtgctccag
gccgcgcagcaggccgtcatgggcaccggcgagcccatggacacctccgaggcagcagca
accgtgactcaggcggagctggggcacctgtcggccgagggtcaggagggccaggccacc
accatacccattgtgctgacacagcaggagctggctgccctggtgcagcagcagcagctg
caggaggcccaggcccagcagcagcatcaccacctccccactgaggccctggcccctgcc
gacagtctcaacgacccagccattgagagcaattgcctcaatgagctggccggcacggtc
cccagcactgtggcgctgctgccctcaacggccactgagagcctggctccatccaacaca
tttgtggccccccagccggttgtggtggccagcccagccaagctgcaggctgcagctacc
ctgaccgaagtggccaatggcatcgagtccctgggtgtgaagccagacctgccgccccca
cccagcaaagcccccatgaagaaggaaaaccagtggtttgatgtgggagtcattaagggc
accaatgtaatggtgacacactatttcctgccaccagatgatgctgtcccatcagacgat
gatttgggcaccgtccctgactataaccagctgaagaagcaggagctgcagccaggcaca
gcctataagtttcgtgttgccggaatcaatgcctgtggccgggggcccttcagcgaaatc
tcagcctttaagacgtgcctgcctggtttcccaggggccccttgtgccattaaaatcagc
aaaagtccggatggtgctcacctcacctgggagccaccctctgtgacctccggcaagatt
atcgagtactccgtgtacctggccatccagagctcacaggctgggggcgagctcaagagc
tccaccccggcccagctggccttcatgcgggtgtactgcgggcccagcccctcctgcctg
gtgcagtcctccagcctttccaacgcccacatcgactacaccaccaagcccgccatcatc
ttccgcatcgccgcccgcaatgagaagggctatggcccggccacacaagtgaggtggctg
caggaaaccagtaaagacagctctggcaccaagccagccaacaagcggcccatgtcctct
ccagaaatgaaatctgctccaaagaaatctaaggccgatggtcagtga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (6)   
   KEGG NETWORK (6)   
Disease (5)   
   KEGG DISEASE (3)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (34)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (32)   
DNA sequence (44)   
   RefSeq(nuc) (32)   
   GenBank (6)   
   EMBL (6)   
3D Structure (11)   
   PDB (11)   
Protein domain (7)   
   Pfam (7)   
All databases (145)   

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