KEGG   Homo sapiens (human): 3141
Entry
3141              CDS       T01001                                 
Symbol
HLCS, HCS
Name
(RefSeq) holocarboxylase synthetase
  KO
K01942  biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00780  Biotin metabolism
hsa01100  Metabolic pathways
Disease
H00180  Holocarboxylase synthetase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00780 Biotin metabolism
    3141 (HLCS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.9  biotin---[methylmalonyl-CoA-carboxytransferase] ligase
     3141 (HLCS)
    6.3.4.10  biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
     3141 (HLCS)
    6.3.4.11  biotin---[methylcrotonoyl-CoA-carboxylase] ligase
     3141 (HLCS)
    6.3.4.15  biotin---[biotin carboxyl-carrier protein] ligase
     3141 (HLCS)
SSDB
Motif
Pfam: BPL_LplA_LipB BPL_C BPL_N
Other DBs
NCBI-GeneID: 3141
NCBI-ProteinID: NP_000402
OMIM: 609018
HGNC: 4976
Ensembl: ENSG00000159267
UniProt: P50747
Position
21:complement(36748625..36990211)
AA seq 726 aa
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggaagatagactccacatggataatggactggtaccccaaaagattgtgtcggtgcac
ttgcaggactccactctgaaggaagttaaggatcaggtctcaaacaagcaagcccagatc
ctagagccgaagcctgaaccttctcttgagattaagcctgagcaggacggtatggagcat
gttggcagagatgacccaaaggctcttggtgaagaacccaaacaaaggagaggcagtgcc
tctgggagtgagcctgctggggacagtgacaggggagggggccccgttgagcattatcac
ctccatctgtctagttgccacgagtgtctggaacttgagaacagcaccattgagtcagtc
aagtttgcgtctgccgagaacattccagaccttccctacgattatagcagcagtttggag
agtgttgctgatgagacctcccccgaaagagaagggaggagagtcaacctcacgggaaag
gcacccaacatcctcctctatgtgggctccgactcccaggaagccctcggccggttccac
gaggtccggtctgtgctggccgactgtgtggacattgacagttatattctctaccacctg
ctggaggacagtgctctcagagacccgtggacggacaactgtctgctgttggtcattgct
accagggagtccattcccgaagacctgtaccagaagttcatggcctatctttctcaggga
gggaaggtgttgggcctgtcttcatccttcacctttggtggctttcaggtgacaagcaag
ggtgcactgcacaagacagtccagaacttggttttctccaaggctgaccagagcgaggtg
aagctcagcgtcttgagcagtggctgcaggtaccaggaaggccccgtccggctcagcccc
ggcaggctccagggccacctggagaatgaggacaaggacaggatgattgtgcatgtgcct
tttggaactcgcgggggagaagctgttctttgccaggtgcacttagaactacctcccagc
tccaacatagtgcaaactccagaagattttaacttgctcaagtcaagcaattttagaaga
tacgaagtccttagagagattctgacaacccttggcctcagctgtgacatgaaacaagtt
cctgccttaactcctctttacttgctgtcagctgcggaggaaatcagggatcctcttatg
cagtggcttgggaaacatgtggactccgagggagaaataaaatccggccagctctctctt
agatttgtttcatcctacgtgtctgaagtagaaataaccccatcttgtatacctgtggtg
accaacatggaggccttctcatcagaacatttcaacttagagatctatcgccaaaatctg
cagaccaagcagttggggaaagtaattttgtttgccgaagtgacccccacaacgatgcgt
ctcctggatgggctgatgtttcagacaccgcaggaaatgggcttaatagtgatcgcggcc
cggcagaccgagggcaaaggacggggagggaatgtgtggctgagccctgtgggatgtgct
ctttctactctgctcatctccattccactgagatcccagctgggacagaggatcccgttt
gtccagcatctgatgtccgtggctgtcgtggaagcagtgaggtccattcccgagtatcag
gatatcaacttacgagtgaagtggcccaacgatatttattacagtgacctcatgaagatc
ggcggagttctggttaactcaacactcatgggagaaacattttatatacttattggctgt
ggatttaatgtgactaacagtaaccctaccatctgcatcaacgacctcatcacagaatac
aataaacaacacaaggcagaactgaagcccttaagagccgattatctcatcgccagagtc
gtgactgtgctggagaaactgatcaaagagtttcaggacaaagggcccaacagcgtcctt
cccctttattaccgatactgggtccacagtggtcagcaagtccatctgggcagcgcagag
ggaccaaaggtgtccatcgttggcctggacgattctggcttcctccaggttcaccaggag
ggcggcgaggttgtgactgtgcacccggacggcaactccttcgacatgctgagaaacctc
atcctccccaaacggcggtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (6)   
   KEGG ENZYME (4)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (24)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (50)   
   RefSeq(nuc) (24)   
   GenBank (13)   
   EMBL (13)   
Protein domain (3)   
   Pfam (3)   
All databases (116)   

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