KEGG T01001: 3269

Homo sapiens (human): 3269

Entry

3269              CDS       T01001

Symbol

HRH1, H1-R, H1R, HH1R, hisH1

Name

(RefSeq) histamine receptor H1

K04149

histamine receptor H1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04750

Inflammatory mediator regulation of TRP channels

Network

nt06528 Calcium signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

Drug target

Acrivastine:

D02760

Alcaftadine:

D06552<US>

Alimemazine (DG01101):

D02245<JP> D07125

Antazoline (DG01037):

D02950 D07458 D07459

Astemizole:

D00234

Azatadine (DG01112):

D00662 D07482

Azelastine (DG01036):

D00659<JP/US> D07483

Bamipine (DG00388):

D07197 D07492 D07493

Barmastine:

D03056

Bepotastine (DG01327):

D01654<JP/US> D09705

Betahistine (DG01004):

D01592<JP> D03102 D07522

Bilastine:

D09570<JP>

Bisulepin:

D07532

Bisulepin hydrochloride:

D07533

Broizine:

D09838

Bromazine:

D03166

Brompheniramine (DG01097):

D00663 D07543

Buclizine (DG01104):

D02089 D07547

Carbinoxamine (DG01095):

D01336<US> D07617 D09808

Cetirizine (DG01107):

D00664<JP/US> D07662

Chloropyramine (DG00384):

D07195 D07679

Chlorphenamine (DG01099):

D00665<JP> D03475 D07398

Chlorphenoxamine (DG00391):

D07198 D07684

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cidoxepin hydrochloride:

D03491

Cinnarizine (DG01005):

D01295 D07734

Clemastine (DG00387):

D00666<JP/US> D03535

Closiramine aceturate:

D03568

Cycliramine maleate:

D03620

Cyclizine (DG01105):

D02090 D03621 D03622

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Deptropine (DG01114):

D07404 D07790

Desloratadine:

D03693<JP/US>

Dexbrompheniramine:

D03704

Dexchlorpheniramine (DG01098):

D00668<JP/US> D07803

Difeterol (DG02077):

D01701 D09747 D09748

Dimenhydrinate:

D00520<JP/US>

Dimetindene (DG00386):

D01343 D07853

Dimetotiazine (DG00843):

D01902<JP> D07854

Dioxopromethazine hydrochloride:

D07860

Diphenhydramine (DG00390):

D00300<JP> D00669<JP/US> D02419 D03285 D03360<JP> D03854

Diphenylimidazole:

D02067

Diphenylpyraline (DG01094):

D01172 D01627 D07862

Dorastine hydrochloride:

D03893

Doxepin (DG00937):

D00814<US> D07875

Doxylamine (DG01096):

D02327 D07878

Ebastine:

D01478<JP>

Efletirizine dihydrochloride:

D03963

Embramine:

D07889

Emedastine (DG01144):

D02249<JP> D07890

Epinastine (DG01116):

D01713<JP/US> D07900

Esmirtazapine maleate:

D04055

Fexofenadine (DG01117):

D00671<JP/US> D07958

Histamine:

D08040<US>

Histamine phosphate:

D04445<US>

Histapyrrodine:

D07400

Homochlorcyclizine (DG01328):

D01460<JP> D08041

Hydroxyzine (DG00912):

D00672<JP/US> D01096<JP/US> D08054

Icotidine:

D04494

Isothipendyl (DG00389):

D01143 D08091

Ketotifen (DG01115):

D01332<JP> D08105

Levocabastine (DG01035):

D01717<JP> D08117

Levocetirizine (DG01108):

D07402 D08118<JP/US>

Loratadine:

D00364<JP>

Mebhydrolin (DG01113):

D01786 D08161

Meclozine (DG01106):

D01317<US> D08163

Mepyramine (DG00382):

D05660 D08183

Mequitazine:

D01324<JP>

Methdilazine (DG01103):

D04979 D04980

Mianserin (DG00951):

D01358<JP> D08216

Mizolastine:

D01117

Noberastine:

D05196

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Olopatadine (DG01039):

D01192<JP/US> D08293

Opipramol (DG00930):

D01477 D08297

Orphenadrine (DG01252):

D08305

Orphenadrine (chloride):

D02599

Orphenadrine (citrate):

D00774<US>

Oxomemazine:

D07401

Phenindamine (DG01110):

D02148 D08353

Pheniramine (DG01100):

D01174 D08355

Phenyltoloxamine citrate:

D08967

Pimethixene:

D07406

Promethazine (DG00385):

D00480<JP/US> D00494 D01242 D03290<JP> D08432 D08768<JP>

Pyroxamine maleate:

D05664

Pyrrobutamine:

D07403

Quifenadine:

D10230

Rocastine hydrochloride:

D05742

Rotoxamine:

D05769

Rupatadine (DG01118):

D07407 D08497<JP>

Sequifenadine:

D10510

Tazifylline hydrochloride:

Tecastemizole:

Temelastine:

Terfenadine:

Tesmilifene hydrochloride:

D06084

Thenalidine:

D07194

Thonzylamine (DG00381):

D01801 D08587

Tolpropamine:

D07196

Tripelennamine (DG00383):

D02091 D06246 D08645

Triprolidine (DG01111):

D01782 D08648

Zolamine hydrochloride:

D06376

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3269 (HRH1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3269 (HRH1)
09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3269 (HRH1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3269 (HRH1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    3269 (HRH1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

3:11137238..11263557

AA seq 487 aa
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

NT seq 1464 nt +upstreamnt +downstreamnt
atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc
actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc
acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact
gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc
atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc
ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc
ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc
aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt
cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt
gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac
ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac
tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg
ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg
aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc
aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc
tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac
tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca
catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga
acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct
aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag
tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc
atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc
tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac
tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag
agaattctgcatattcgctcctaa

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