Entry |
|
Symbol |
HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1
|
Name |
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
KO |
|
Organism |
|
Pathway |
hsa04925 | Aldosterone synthesis and secretion |
hsa04927 | Cortisol synthesis and secretion |
|
Module |
hsa_M00107 | Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone |
hsa_M00110 | C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone |
hsa_M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
hsa_M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
|
Network |
nt06019 Steroid hormone biosynthesis |
Element |
N00759 | Steroid hormone biosynthesis, cholesterol to pregnenolone/progesterone |
N01541 | Testosterone biosynthesis |
N01802 | Dihydrotestosterone biosynthesis |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
3283 (HSD3B1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
3283 (HSD3B1)
04925 Aldosterone synthesis and secretion
3283 (HSD3B1)
04927 Cortisol synthesis and secretion
3283 (HSD3B1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
3283 (HSD3B1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
3283 (HSD3B1)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
3283 (HSD3B1)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
1:119507203..119515058
|
AA seq |
373 aa
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTL
YTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
QDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEI
VSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSL
VDRHKETLKSKTQ |
NT seq |
1122 nt +upstreamnt +downstreamnt
atgacgggctggagctgccttgtgacaggagcaggagggtttctgggacagaggatcatc
cgcctcttggtgaaggagaaggagctgaaggagatcagggtcttggacaaggccttcgga
ccagaattgagagaggaattttctaaactccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtcatcatc
cacaccgcctgtatcattgatgtcttcggtgtcactcacagagagtctatcatgaatgtc
aatgtgaaaggtacccagctcctgttagaggcctgtgtccaagctagtgtgccagtcttc
atctacaccagtagcatagaggtagccgggcccaactcctacaaggaaatcatccagaat
ggccatgaagaagagcctctggaaaacacatggcccgctccatacccacacagcaaaaag
cttgctgagaaggctgtactggcggctaacgggtggaatctgaaaaacggcggcaccctg
tacacttgtgccttacgacccatgtatatctatggggaaggaagccgattcctttctgct
agtataaacgaggccctgaacaacaatgggatcctgtcaagtgttggaaagttctccact
gttaacccagtctatgttggcaatgtggcctgggcccacattctggccttgagggccctg
caggaccccaagaaggccccaagcatccgaggacagttctactatatctcagatgacacg
cctcaccaaagctatgataaccttaattacaccctgagcaaagagttcggcctccgcctt
gattccagatggagctttcctttatccctgatgtattggattggcttcctgctggaaata
gtgagcttcctactcaggccaatttacacctatcgaccgcccttcaaccgccacatagtc
acattgtcaaatagcgtattcaccttctcttataagaaggctcagcgagatctggcgtat
aagccactctacagctgggaggaagccaagcagaaaacggtggagtgggttggttccctt
gtggaccggcacaaggagaccctgaagtccaagactcagtga |