KEGG   Homo sapiens (human): 3340
Entry
3340              CDS       T01001                                 
Symbol
NDST1, HSST, MRT46, NST1
Name
(RefSeq) N-deacetylase and N-sulfotransferase 1
  KO
K02576  heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.5.1.- 2.8.2.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100  Metabolic pathways
Module
hsa_M00059  Glycosaminoglycan biosynthesis, heparan sulfate backbone
Network
nt06029  Glycosaminoglycan biosynthesis
  Element
N01582  Heparan sulfate biosynthesis
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    3340 (NDST1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases [BR:hsa01003]
    3340 (NDST1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.2  Sulfotransferases
    2.8.2.8  [heparan sulfate]-glucosamine N-sulfotransferase
     3340 (NDST1)
Glycosyltransferases [BR:hsa01003]
 Unclassified
  Sulfotransferases
   3340 (NDST1)
SSDB
Motif
Pfam: HSNSD Sulfotransfer_1 Sulfotransfer_3
Other DBs
NCBI-GeneID: 3340
NCBI-ProteinID: NP_001534
OMIM: 600853
HGNC: 7680
Ensembl: ENSG00000070614
UniProt: P52848 A8K8T3
Structure
Position
5:150497779..150558211
AA seq 882 aa
MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPP
PVAPSRLLPLKPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKG
DMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSA
QLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL
AKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAF
LTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSG
KFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHG
IPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMV
LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGL
YTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKT
CDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYME
FFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAH
DDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKL
LRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEM
DLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR
NT seq 2649 nt   +upstreamnt  +downstreamnt
atgcctgccctggcatgcctccggaggctgtgtcggcacgtgtccccgcaggctgtcctt
ttcctgctgttcatcttctgcctgttcagcgttttcatctcggcctactacctatatggc
tggaagcgaggcctggagccctcggcggatgcccccgagcctgactgcggggacccgccg
cctgtggcccccagtcgcctgctgccactcaagcctgtgcaggcagccaccccttcccgc
acagacccgttggtgctggtctttgtggagagcctctactcgcaactgggccaggaggtg
gtggccatcctggagtccagccgcttcaaataccgcacagagattgcgccgggcaagggt
gacatgcccacgctcactgacaagggccgtggccgcttcgccctcatcatctatgagaac
atcctcaagtatgtcaacctggacgcctggaaccgggagctgctggacaagtactgtgtg
gcctacggcgtgggcatcattggcttcttcaaggccaatgagaacagcctgctgagtgcg
cagctcaagggcttccccctgttcctgcactcaaacctgggcctgaaggactgcagcatc
aaccccaagtccccgctgctctacgtgacgcgacctagcgaggtggagaaaggtgtgctc
cccggcgaggactggacggttttccagtcaaatcactccacctatgagccagtgctgctg
gccaagacgcgctcgtctgagtccatcccacacctgggcgcagacgccggcctgcatgct
gcactgcacgccactgtggtccaggacctgggcctgcacgacggcatccagcgcgtgctg
tttggcaacaacctgaacttctggctgcacaagcttgtcttcgtggatgccgtggccttc
ctcacggggaagcgcctctccctgccattggaccgctacatcctggtggacattgatgac
atcttcgtgggcaaggagggcacacgcatgaaggtggaggacgtgaaggccctgtttgac
acacagaacgaactacgcgcacacatcccaaacttcaccttcaacctgggctactcaggg
aaattcttccacacaggtaccaatgctgaggacgctggggatgatctgctgctgtcgtat
gtgaaggagttctggtggttcccccacatgtggagccacatgcagccccaccttttccac
aaccagtccgtgttggccgagcagatggccttgaacaagaagttcgctgtcgagcatggc
attcccacagacatggggtatgcagtggcgccccaccactcgggcgtgtaccccgtgcac
gtgcagctgtacgaggcttggaagcaggtgtggagcatccgcgtgaccagcacggaggag
tacccccacctgaagccagcccgctaccgccgtggcttcatccacaatggcatcatggtt
ctcccacggcagacctgcggcctcttcacacacaccatcttctacaacgagtaccctggc
ggctccagtgagctggacaagatcatcaacgggggcgagctcttcctcaccgtgctcctc
aatcctatcagcatcttcatgacgcacctgtccaactatgggaatgaccgcctgggcctg
tacaccttcaagcacctggtgcgcttcctgcactcctggacgaacctccggctgcagaca
ctgccccctgtgcagttggcgcagaagtacttccagatcttctccgaggagaaggacccg
ctctggcaggacccctgcgaggacaaacgtcacaaagacatctggtccaaggagaagacg
tgtgaccgcttcccaaagctcctcatcatcggcccccagaaaacaggcaccactgccctc
tacctgttcctgggcatgcaccctgacctaagcagcaactaccccagctctgagaccttt
gaggagatccagttttttaatggccacaactatcacaaaggcatcgactggtacatggag
ttcttccccatcccttccaacaccacctccgacttctactttgagaaaagcgccaactac
tttgattcagaagtggcgccccggcgggcagcagccctcttgcccaaagccaaggtcctg
accatcctcatcaaccccgcggaccgggcctattcctggtaccagcaccagcgagcccat
gacgacccagtggccctaaagtacaccttccatgaggtgattaccgccggctctgacgca
tcctcgaagctgcgtgccctccagaaccgctgcctggtccctggctggtacgccacccac
atcgagcgctggctcagtgcctatcacgccaaccagattctggtcttggatggcaaactg
cttcgcacagaacctgccaaagtgatggacatggtgcagaagttccttggggtgaccaac
accattgactaccacaaaaccttggcgtttgatccaaagaaaggattttggtgccaactg
cttgaaggaggaaaaaccaagtgtctgggcaaaagcaagggccggaaatatcccgagatg
gacttggattcccgagccttcctgaaggactattaccgggaccacaacatcgagctctcc
aagctgctgtataagatgggccagacacttcccacttggctacgagaggacctccagaac
accaggtag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (68)   

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