KEGG   Homo sapiens (human): 3418
Entry
3418              CDS       T01001                                 
Symbol
IDH2, D2HGA2, ICD-M, IDH, IDH-2, IDHM, IDP, IDPM, mNADP-IDH
Name
(RefSeq) isocitrate dehydrogenase (NADP(+)) 2
  KO
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
hsa01230  Biosynthesis of amino acids
hsa04146  Peroxisome
hsa05230  Central carbon metabolism in cancer
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Network
nt06026  Glutathione biosynthesis
nt06031  Citrate cycle and pyruvate metabolism
  Element
N00905  NADP+ reduction
N01604  Citrate cycle, first carbon oxidation
Disease
H01225  D-2-hydroxyglutaric aciduria
H01892  Peripheral T cell lymphoma
H02410  Myelodysplastic/myeloproliferative neoplasms
H02412  Atypical chronic myeloid leukemia
Drug target
Enasidenib (DG02837): D10901 D11044<US>
Vorasidenib (DG03113): D11834 D11835
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    3418 (IDH2)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    3418 (IDH2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    3418 (IDH2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    3418 (IDH2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42  isocitrate dehydrogenase (NADP+)
     3418 (IDH2)
SSDB
Motif
Pfam: Iso_dh
Other DBs
NCBI-GeneID: 3418
NCBI-ProteinID: NP_002159
OMIM: 147650
HGNC: 5383
Ensembl: ENSG00000182054
UniProt: P48735
Structure
Position
15:complement(90083045..90102468)
AA seq 452 aa
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggccggctacctgcgggtcgtgcgctcgctctgcagagcctcaggctcgcggccggcc
tgggcgccggcggccctgacagcccccacctcgcaagagcagccgcggcgccactatgcc
gacaaaaggatcaaggtggcgaagcccgtggtggagatggatggtgatgagatgacccgt
attatctggcagttcatcaaggagaagctcatcctgccccacgtggacatccagctaaag
tattttgacctcgggctcccaaaccgtgaccagactgatgaccaggtcaccattgactct
gcactggccacccagaagtacagtgtggctgtcaagtgtgccaccatcacccctgatgag
gcccgtgtggaagagttcaagctgaagaagatgtggaaaagtcccaatggaactatccgg
aacatcctgggggggactgtcttccgggagcccatcatctgcaaaaacatcccacgccta
gtccctggctggaccaagcccatcaccattggcaggcacgcccatggcgaccagtacaag
gccacagactttgtggcagaccgggccggcactttcaaaatggtcttcaccccaaaagat
ggcagtggtgtcaaggagtgggaagtgtacaacttccccgcaggcggcgtgggcatgggc
atgtacaacaccgacgagtccatctcaggttttgcgcacagctgcttccagtatgccatc
cagaagaaatggccgctgtacatgagcaccaagaacaccatactgaaagcctacgatggg
cgtttcaaggacatcttccaggagatctttgacaagcactataagaccgacttcgacaag
aataagatctggtatgagcaccggctcattgatgacatggtggctcaggtcctcaagtct
tcgggtggctttgtgtgggcctgcaagaactatgacggagatgtgcagtcagacatcctg
gcccagggctttggctcccttggcctgatgacgtccgtcctggtctgccctgatgggaag
acgattgaggctgaggccgctcatgggaccgtcacccgccactatcgggagcaccagaag
ggccggcccaccagcaccaaccccatcgccagcatctttgcctggacacgtggcctggag
caccgggggaagctggatgggaaccaagacctcatcaggtttgcccagatgctggagaag
gtgtgcgtggagacggtggagagtggagccatgaccaaggacctggcgggctgcattcac
ggcctcagcaatgtgaagctgaacgagcacttcctgaacaccacggacttcctcgacacc
atcaagagcaacctggacagagccctgggcaggcagtag

DBGET integrated database retrieval system