KEGG   Homo sapiens (human): 3481
Entry
3481              CDS       T01001                                 
Symbol
IGF2, C11orf43, GRDF, IGF-II, PP9974, SRS3
Name
(RefSeq) insulin like growth factor 2
  KO
K13769  insulin-like growth factor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06324  GHRH-GH-IGF signaling
nt06526  MAPK signaling
nt06530  PI3K signaling
  Element
N00233  IGF-IGF1R-RAS-ERK signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
Disease
H00033  Adrenal carcinoma
H00048  Hepatocellular carcinoma
H00711  Russell-Silver syndrome
H00713  Beckwith-Wiedemann syndrome
Drug target
Dusigitumab: D10352
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3481 (IGF2)
   04014 Ras signaling pathway
    3481 (IGF2)
   04151 PI3K-Akt signaling pathway
    3481 (IGF2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3481 (IGF2)
   05205 Proteoglycans in cancer
    3481 (IGF2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    3481 (IGF2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3481 (IGF2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3481 (IGF2)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Growth factors (RTK binding)
   3481 (IGF2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   3481 (IGF2)
SSDB
Motif
Pfam: IGF2_C Insulin
Other DBs
NCBI-GeneID: 3481
NCBI-ProteinID: NP_000603
OMIM: 147470
HGNC: 5466
Ensembl: ENSG00000167244
CPD: C16132
UniProt: P01344
Structure
Position
11:complement(2129117..2149566)
AA seq 180 aa
MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVS
RRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWK
QSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK
NT seq 543 nt   +upstreamnt  +downstreamnt
atgggaatcccaatggggaagtcgatgctggtgcttctcaccttcttggccttcgcctcg
tgctgcattgctgcttaccgccccagtgagaccctgtgcggcggggagctggtggacacc
ctccagttcgtctgtggggaccgcggcttctacttcagcaggcccgcaagccgtgtgagc
cgtcgcagccgtggcatcgttgaggagtgctgtttccgcagctgtgacctggccctcctg
gagacgtactgtgctacccccgccaagtccgagagggacgtgtcgacccctccgaccgtg
cttccggacaacttccccagataccccgtgggcaagttcttccaatatgacacctggaag
cagtccacccagcgcctgcgcaggggcctgcctgccctcctgcgtgcccgccggggtcac
gtgctcgccaaggagctcgaggcgttcagggaggccaaacgtcaccgtcccctgattgct
ctacccacccaagaccccgcccacgggggcgcccccccagagatggccagcaatcggaag
tga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Network (15)   
   KEGG NETWORK (15)   
Disease (9)   
   KEGG DISEASE (4)   
   OMIM (5)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (20)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (73)   
   RefSeq(nuc) (5)   
   GenBank (34)   
   EMBL (34)   
3D Structure (11)   
   PDB (11)   
Protein domain (2)   
   Pfam (2)   
All databases (156)   

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