KEGG   Homo sapiens (human): 348980
Entry
348980            CDS       T01001                                 
Symbol
HCN1, BCNG-1, BCNG1, DEE24, EIEE24, GEFSP10, HAC-2
Name
(RefSeq) hyperpolarization activated cyclic nucleotide gated potassium channel 1
  KO
K04954  hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04929  GnRH secretion
Disease
H00606  Early infantile epileptic encephalopathy
H02564  Generalized epilepsy with febrile seizures plus
Drug target
Ivabradine (DG00246): D07165 D08095<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    348980 (HCN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    348980 (HCN1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Cyclic nucleotide-gated channel (HCN)
   348980 (HCN1)
SSDB
Motif
Pfam: Ion_trans Ion_trans_N cNMP_binding Ion_trans_2 DUF1759
Other DBs
NCBI-GeneID: 348980
NCBI-ProteinID: NP_066550
OMIM: 602780
HGNC: 4845
Ensembl: ENSG00000164588
UniProt: O60741 Q86WJ6
Structure
Position
5:complement(45254948..45696380)
AA seq 890 aa
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFK
VDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAV
EKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN
LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIG
YGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANAD
PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE
ICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
LLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRM
RTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYA
SPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLT
REVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT
LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
NT seq 2673 nt   +upstreamnt  +downstreamnt
atggaaggaggcggcaagcccaactcttcgtctaacagccgggacgatggcaacagcgtc
ttccccgccaaggcgtccgcgacgggcgcggggccggccgcggccgagaagcgcctgggc
accccgccggggggcggcggggccggcgcgaaggagcacggcaactccgtgtgcttcaag
gtggacggcggtggcggcggtggcggcggcggcggcggcggcgaggagccggcggggggc
ttcgaagacgccgaggggccccggcggcagtacggcttcatgcagaggcagttcacctcc
atgctgcagcccggggtcaacaaattctccctccgcatgtttgggagccagaaggcggtg
gaaaaggagcaggaaagggttaaaactgcaggcttctggattatccacccttacagtgat
ttcaggttttactgggatttaataatgcttataatgatggttggaaatctagtcatcata
ccagttggaatcacattctttacagagcaaacaacaacaccatggattattttcaatgtg
gcatcagatacagttttcctattggacctgatcatgaattttaggactgggactgtcaat
gaagacagttctgaaatcatcctggaccccaaagtgatcaagatgaattatttaaaaagc
tggtttgtggttgacttcatctcatccatcccagtggattatatctttcttattgtagaa
aaaggaatggattctgaagtttacaagacagccagggcacttcgcattgtgaggtttaca
aaaattctcagtctcttgcgtttattacgactttcaaggttaattagatacatacatcaa
tgggaagagatattccacatgacatatgatctcgccagtgcagtggtgagaatttttaat
ctcatcggcatgatgctgctcctgtgccactgggatggttgtcttcagttcttagtacca
ctactgcaggacttcccaccagattgctgggtgtctttaaatgaaatggttaatgattct
tggggaaagcagtattcatacgcactcttcaaagctatgagtcacatgctgtgcattggg
tatggagcccaagccccagtcagcatgtctgacctctggattaccatgctgagcatgatc
gtcggggccacctgctatgccatgtttgtcggccatgccaccgctttaatccagtctctg
gattcttcgaggcggcagtatcaagagaagtataagcaagtggaacaatacatgtcattc
cataagttaccagctgatatgcgtcagaagatacatgattactatgaacacagataccaa
ggcaaaatctttgatgaggaaaatattctcaatgaactcaatgatcctctgagagaggag
atagtcaacttcaactgtcggaaactggtggctacaatgcctttatttgctaatgcggat
cctaattttgtgactgccatgctgagcaagttgagatttgaggtgtttcaacctggagat
tatatcatacgagaaggagccgtgggtaaaaaaatgtatttcattcaacacggtgttgct
ggtgtcattacaaaatccagtaaagaaatgaagctgacagatggctcttactttggagag
atttgcctgctgaccaaaggacgtcgtactgccagtgttcgagctgatacatattgtcgt
ctttactcactttccgtggacaatttcaacgaggtcctggaggaatatccaatgatgagg
agagcctttgagacagttgccattgaccgactagatcgaataggaaagaaaaattcaatt
cttctgcaaaagttccagaaggatctgaacactggtgttttcaacaatcaggagaacgaa
atcctcaagcagattgtgaaacatgacagggagatggtgcaggcaatcgctcccatcaat
tatcctcaaatgacaaccctgaattccacatcgtctactacgaccccgacctcccgcatg
aggacacaatctccaccggtgtacacagcgaccagcctgtctcacagcaacctgcactcc
cccagtcccagcacacagaccccccagccatcagccatcctgtcaccctgctcctacacc
accgcggtctgcagccctcctgtacagagccctctggccgctcgaactttccactatgcc
tcccccaccgcctcccagctgtcactcatgcaacagcagccgcagcagcaggtacagcag
tcccagccgccgcagactcagccacagcagccgtccccgcagccacagacacctggcagc
tccacgccgaaaaatgaagtgcacaagagcacgcaggcgcttcacaacaccaacctgacc
cgggaagtcaggccactctccgcctcgcagccctcgctgccccatgaggtgtccactctg
atttccagacctcatcccactgtgggcgagtccctggcctccatccctcaacccgtgacg
gcggtccccggaacgggccttcaggcagggggcaggagcactgtcccgcagcgcgtcacc
ctcttccgacagatgtcgtcgggagccatccccccgaaccgaggagtccctccagcaccc
cctccaccagcagctgctcttccaagagaatcttcctcagtcttaaacacagacccagac
gcagaaaagccacgatttgcttcaaatttatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (58)   

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