KEGG T01001: 3563

Homo sapiens (human): 3563

Entry

3563              CDS       T01001

Symbol

IL3RA, CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra

Name

(RefSeq) interleukin 3 receptor subunit alpha

K04737

interleukin 3 receptor alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04151

PI3K-Akt signaling pathway

hsa04210

Apoptosis

hsa04630

JAK-STAT signaling pathway

hsa04640

Hematopoietic cell lineage

hsa05200

Pathways in cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling

Element

N00053

Cytokine-Jak-STAT signaling pathway

N01804

IL3 family to Jak-STAT signaling pathway

Drug target

Daniplestim:

Flotetuzumab:

Leridistim:

Milodistim:

Muplestim:

Pivekimab:

Pivekimab sunirine:

Tagraxofusp:

D11358<US>

Vibecotamab:

D11841

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3563 (IL3RA)
   04151 PI3K-Akt signaling pathway
    3563 (IL3RA)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3563 (IL3RA)
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    3563 (IL3RA)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3563 (IL3RA)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3563 (IL3RA)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3563 (IL3RA)
   04090 CD molecules [BR:hsa04090]
    3563 (IL3RA)
Cytokine receptors [BR:hsa04050]
Interleukin receptor families
  IL3 receptor family
   3563 (IL3RA)
CD molecules [BR:hsa04090]
Proteins
  3563 (IL3RA)

SSDB

Motif

Pfam:

IL6Ra-bind IL3Ra_N LIFR_N EpoR_lig-bind Tissue_fac Y_Y_Y

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

ENSG00000185291 ENSG00000292332

UniProt:

P26951

Structure

Position

X:1336785..1382689, Y:1336785..1382689

AA seq 378 aa
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT

NT seq 1137 nt +upstreamnt +downstreamnt
atggtcctcctttggctcacgctgctcctgatcgccctgccctgtctcctgcaaacgaag
gaagatccaaacccaccaatcacgaacctaaggatgaaagcaaaggctcagcagttgacc
tgggaccttaacagaaatgtgaccgatatcgagtgtgttaaagacgccgactattctatg
ccggcagtgaacaatagctattgccagtttggagcaatttccttatgtgaagtgaccaac
tacaccgtccgagtggccaacccaccattctccacgtggatcctcttccctgagaacagt
gggaagccttgggcaggtgcggagaatctgacctgctggattcatgacgtggatttcttg
agctgcagctgggcggtaggcccgggggcccccgcggacgtccagtacgacctgtacttg
aacgttgccaacaggcgtcaacagtacgagtgtcttcactacaaaacggatgctcaggga
acacgtatcgggtgtcgtttcgatgacatctctcgactctccagcggttctcaaagttcc
cacatcctggtgcggggcaggagcgcagccttcggtatcccctgcacagataagtttgtc
gtcttttcacagattgagatattaactccacccaacatgactgcaaagtgtaataagaca
cattcctttatgcactggaaaatgagaagtcatttcaatcgcaaatttcgctatgagctt
cagatacaaaagagaatgcagcctgtaatcacagaacaggtcagagacagaacctccttc
cagctactcaatcctggaacgtacacagtacaaataagagcccgggaaagagtgtatgaa
ttcttgagcgcctggagcaccccccagcgcttcgagtgcgaccaggaggagggcgcaaac
acacgtgcctggcggacgtcgctgctgatcgcgctggggacgctgctggccctggtctgt
gtcttcgtgatctgcagaaggtatctggtgatgcagagactctttccccgcatccctcac
atgaaagaccccatcggtgacagcttccaaaacgacaagctggtggtctgggaggcgggc
aaagccggcctggaggagtgtctggtgactgaagtacaggtcgtgcagaaaacttga

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