KEGG   Homo sapiens (human): 3606
Entry
3606              CDS       T01001                                 
Symbol
IL18, IGIF, IL-18, IL-1g, IL1F4
Name
(RefSeq) interleukin 18
  KO
K05482  interleukin 18
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
Network
nt06170  Influenza A virus (IAV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06521  NLR signaling
  Element
N00742  NLRP3 inflammasome signaling pathway
N00867  NLRC4 inflammasome signaling pathway
N00868  Pyrin inflammasome signaling pathway
N00934  Non-canonical inflammasome signaling pathway
N01126  Salmonella SipB to Inflammasome signaling pathway
N01127  Salmonella SopE to Inflammasome signaling pathway
N01567  NLRP1 inflammasome signaling pathway
N01569  NALP12 inflammasome signaling pathway
Drug target
Iboctadekin: D04487
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3606 (IL18)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3606 (IL18)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    3606 (IL18)
   04623 Cytosolic DNA-sensing pathway
    3606 (IL18)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    3606 (IL18)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3606 (IL18)
   05132 Salmonella infection
    3606 (IL18)
   05131 Shigellosis
    3606 (IL18)
   05135 Yersinia infection
    3606 (IL18)
   05134 Legionellosis
    3606 (IL18)
   05152 Tuberculosis
    3606 (IL18)
  09174 Infectious disease: parasitic
   05144 Malaria
    3606 (IL18)
   05143 African trypanosomiasis
    3606 (IL18)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3606 (IL18)
   05321 Inflammatory bowel disease
    3606 (IL18)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3606 (IL18)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3606 (IL18)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3606 (IL18)
SSDB
Motif
Pfam: IL1
Other DBs
NCBI-GeneID: 3606
NCBI-ProteinID: NP_001553
OMIM: 600953
HGNC: 5986
Ensembl: ENSG00000150782
UniProt: Q14116
Structure
Position
11:complement(112143260..112164094)
AA seq 193 aa
MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQ
GNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFK
EMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDEL
GDRSIMFTVQNED
NT seq 582 nt   +upstreamnt  +downstreamnt
atggctgctgaaccagtagaagacaattgcatcaactttgtggcaatgaaatttattgac
aatacgctttactttatagctgaagatgatgaaaacctggaatcagattactttggcaag
cttgaatctaaattatcagtcataagaaatttgaatgaccaagttctcttcattgaccaa
ggaaatcggcctctatttgaagatatgactgattctgactgtagagataatgcaccccgg
accatatttattataagtatgtataaagatagccagcctagaggtatggctgtaactatc
tctgtgaagtgtgagaaaatttcaactctctcctgtgagaacaaaattatttcctttaag
gaaatgaatcctcctgataacatcaaggatacaaaaagtgacatcatattctttcagaga
agtgtcccaggacatgataataagatgcaatttgaatcttcatcatacgaaggatacttt
ctagcttgtgaaaaagagagagacctttttaaactcattttgaaaaaagaggatgaattg
ggggatagatctataatgttcactgttcaaaacgaagactag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Network (14)   
   KEGG NETWORK (14)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (29)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (31)   
   RefSeq(nuc) (5)   
   GenBank (13)   
   EMBL (13)   
3D Structure (16)   
   PDB (16)   
Protein domain (1)   
   Pfam (1)   
All databases (128)   

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