KEGG   Homo sapiens (human): 3615
Entry
3615              CDS       T01001                                 
Symbol
IMPDH2, IMPD2, IMPDH-II
Name
(RefSeq) inosine monophosphate dehydrogenase 2
  KO
K00088  IMP dehydrogenase [EC:1.1.1.205]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Module
hsa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
Drug target
Merimepodib: D04936
Mizoribine: D01392<JP>
Mycophenolic acid (DG00739): D00752<JP/US> D05094<US> D05095<US> D05096
Tiazofurine: D06130
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    3615 (IMPDH2)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    3615 (IMPDH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3615 (IMPDH2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.205  IMP dehydrogenase
     3615 (IMPDH2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3615 (IMPDH2)
  Exosomal proteins of breast cancer cells
   3615 (IMPDH2)
SSDB
Motif
Pfam: IMPDH CBS NMO FMN_dh His_biosynth NanE ThiG Dus B12-binding Glu_synthase G3P_antiterm YceG_bac DUF561 DHO_dh
Other DBs
NCBI-GeneID: 3615
NCBI-ProteinID: NP_000875
OMIM: 146691
HGNC: 6053
Ensembl: ENSG00000178035
UniProt: P12268 A0A384N6C2
Structure
Position
3:complement(49024325..49029398)
AA seq 514 aa
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
NT seq 1545 nt   +upstreamnt  +downstreamnt
atggccgactacctgattagtgggggcacgtcctacgtgccagacgacggactcacagca
cagcagctcttcaactgcggagacggcctcacctacaatgactttctcattctccctggg
tacatcgacttcactgcagaccaggtggacctgacttctgctctgaccaagaaaatcact
cttaagaccccactggtttcctctcccatggacacagtcacagaggctgggatggccata
gcaatggcgcttacaggcggtattggcttcatccaccacaactgtacacctgaattccag
gccaatgaagttcggaaagtgaagaaatatgaacagggattcatcacagaccctgtggtc
ctcagccccaaggatcgcgtgcgggatgtttttgaggccaaggcccggcatggtttctgc
ggtatcccaatcacagacacaggccggatggggagccgcttggtgggcatcatctcctcc
agggacattgattttctcaaagaggaggaacatgactgtttcttggaagagataatgaca
aagagggaagacttggtggtagcccctgcaggcatcacactgaaggaggcaaatgaaatt
ctgcagcgcagcaagaagggaaagttgcccattgtaaatgaagatgatgagcttgtggcc
atcattgcccggacagacctgaagaagaatcgggactacccactagcctccaaagatgcc
aagaaacagctgctgtgtggggcagccattggcactcatgaggatgacaagtataggctg
gacttgctcgcccaggctggtgtggatgtagtggttttggactcttcccagggaaattcc
atcttccagatcaatatgatcaagtacatcaaagacaaataccctaatctccaagtcatt
ggaggcaatgtggtcactgctgcccaggccaagaacctcattgatgcaggtgtggatgcc
ctgcgggtgggcatgggaagtggctccatctgcattacgcaggaagtgctggcctgtggg
cggccccaagcaacagcagtgtacaaggtgtcagagtatgcacggcgctttggtgttccg
gtcattgctgatggaggaatccaaaatgtgggtcatattgcgaaagccttggcccttggg
gcctccacagtcatgatgggctctctcctggctgccaccactgaggcccctggtgaatac
ttcttttccgatgggatccggctaaagaaatatcgcggtatgggttctctcgatgccatg
gacaagcacctcagcagccagaacagatatttcagtgaagctgacaaaatcaaagtggcc
cagggagtgtctggtgctgtgcaggacaaagggtcaatccacaaatttgtcccttacctg
attgctggcatccaacactcatgccaggacattggtgccaagagcttgacccaagtccga
gccatgatgtactctggggagcttaagtttgagaagagaacgtcctcagcccaggtggaa
ggtggcgtccatagcctccattcgtatgagaagcggcttttctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (2)   
   OMIM (2)   
Drug (7)   
   KEGG DRUG (7)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (20)   
   RefSeq(nuc) (4)   
   GenBank (8)   
   EMBL (8)   
3D Structure (22)   
   PDB (22)   
Protein domain (14)   
   Pfam (14)   
All databases (118)   

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