KEGG   Homo sapiens (human): 3620
Entry
3620              CDS       T01001                                 
Symbol
IDO1, IDO, IDO-1, INDO
Name
(RefSeq) indoleamine 2,3-dioxygenase 1
  KO
K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05143  African trypanosomiasis
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Drug target
Epacadostat: D11049
Indoximod: D10640
Linrodostat (DG03010): D11412 D11413
Navoximod: D11255
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    3620 (IDO1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    3620 (IDO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.52  indoleamine 2,3-dioxygenase
     3620 (IDO1)
SSDB
Motif
Pfam: IDO PrnB Meckelin
Other DBs
NCBI-GeneID: 3620
NCBI-ProteinID: NP_002155
OMIM: 147435
HGNC: 6059
Ensembl: ENSG00000131203
UniProt: P14902 A0A348GSI3
Structure
Position
8:39913891..39928790
AA seq 403 aa
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
NT seq 1212 nt   +upstreamnt  +downstreamnt
atggcacacgctatggaaaactcctggacaatcagtaaagagtaccatattgatgaagaa
gtgggctttgctctgccaaatccacaggaaaatctacctgatttttataatgactggatg
ttcattgctaaacatctgcctgatctcatagagtctggccagcttcgagaaagagttgag
aagttaaacatgctcagcattgatcatctcacagaccacaagtcacagcgccttgcacgt
ctagttctgggatgcatcaccatggcatatgtgtggggcaaaggtcatggagatgtccgt
aaggtcttgccaagaaatattgctgttccttactgccaactctccaagaaactggaactg
cctcctattttggtttatgcagactgtgtcttggcaaactggaagaaaaaggatcctaat
aagcccctgacttatgagaacatggacgttttgttctcatttcgtgatggagactgcagt
aaaggattcttcctggtctctctattggtggaaatagcagctgcttctgcaatcaaagta
attcctactgtattcaaggcaatgcaaatgcaagaacgggacactttgctaaaggcgctg
ttggaaatagcttcttgcttggagaaagcccttcaagtgtttcaccaaatccacgatcat
gtgaacccaaaagcatttttcagtgttcttcgcatatatttgtctggctggaaaggcaac
ccccagctatcagacggtctggtgtatgaagggttctgggaagacccaaaggagtttgca
gggggcagtgcaggccaaagcagcgtctttcagtgctttgacgtcctgctgggcatccag
cagactgctggtggaggacatgctgctcagttcctccaggacatgagaagatatatgcca
ccagctcacaggaacttcctgtgctcattagagtcaaatccctcagtccgtgagtttgtc
ctttcaaaaggtgatgctggcctgcgggaagcttatgacgcctgtgtgaaagctctggtc
tccctgaggagctaccatctgcaaatcgtgactaagtacatcctgattcctgcaagccag
cagccaaaggagaataagacctctgaagacccttcaaaactggaagccaaaggaactgga
ggcactgatttaatgaatttcctgaagactgtaagaagtacaactgagaaatcccttttg
aaggaaggttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (71)   
   PDB (71)   
Protein domain (3)   
   Pfam (3)   
All databases (145)   

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