KEGG   Homo sapiens (human): 3635
Entry
3635              CDS       T01001                                 
Symbol
INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
Name
(RefSeq) inositol polyphosphate-5-phosphatase D
  KO
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
Drug target
Rosiptor (DG02961): D11275 D11276
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    3635 (INPP5D)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    3635 (INPP5D)
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    3635 (INPP5D)
   04664 Fc epsilon RI signaling pathway
    3635 (INPP5D)
   04666 Fc gamma R-mediated phagocytosis
    3635 (INPP5D)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3635 (INPP5D)
   03036 Chromosome and associated proteins [BR:hsa03036]
    3635 (INPP5D)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     3635 (INPP5D)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    3635 (INPP5D)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    SHIP complex
     3635 (INPP5D)
SSDB
Motif
Pfam: SH2
Other DBs
NCBI-GeneID: 3635
NCBI-ProteinID: NP_001017915
OMIM: 601582
HGNC: 6079
Ensembl: ENSG00000168918
UniProt: Q92835
Structure
Position
2:233060342..233207903
AA seq 1189 aa
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV
VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH
LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ
QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT
FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL
VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK
KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV
AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS
HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE
TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK
ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN
GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF
GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH
GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP
PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES
PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP
LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA
PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR
PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ
NT seq 3570 nt   +upstreamnt  +downstreamnt
atggtcccctgctggaaccatggcaacatcacccgctccaaggcggaggagctgctttcc
aggacaggcaaggacgggagcttcctcgtgcgtgccagcgagtccatctcccgggcatac
gcgctctgcgtgctgtatcggaattgcgtttacacttacagaattctgcccaatgaagat
gataaattcactgttcaggcatccgaaggcgtctccatgaggttcttcaccaagctggac
cagctcatcgagttttacaagaaggaaaacatggggctggtgacccatctgcaataccct
gtgccgctggaggaagaggacacaggcgacgaccctgaggaggacacagtagaaagtgtc
gtgtctccacccgagctgcccccaagaaacatcccgctgactgccagctcctgtgaggcc
aaggaggttcctttttcaaacgagaatccccgagcgaccgagaccagccggccgagcctc
tccgagacattgttccagcgactgcaaagcatggacaccagtgggcttccagaagagcat
cttaaggccatccaagattatttaagcactcagctcgcccaggactctgaatttgtgaag
acagggtccagcagtcttcctcacctgaagaaactgaccacactgctctgcaaggagctc
tatggagaagtcatccggaccctcccatccctggagtctctgcagaggttatttgaccag
cagctctccccgggcctccgtccacgtcctcaggttcctggtgaggccaatcccatcaac
atggtgtccaagctcagccaactgacaagcctgttgtcgtccattgaagacaaggtcaag
gccttgctgcacgagggtcctgagtctccgcaccggccctcccttatccctccagtcacc
tttgaggtgaaggcagagtctctggggattcctcagaaaatgcagctcaaagtcgacgtt
gagtctgggaaactgatcattaagaagtccaaggatggttctgaggacaagttctacagc
cacaagaaaatcctgcagctcattaagtcacagaaatttctgaataagttggtgatcttg
gtggaaacagagaaggagaagatcctgcggaaggaatatgtttttgctgactccaaaaag
agagaaggcttctgccagctcctgcagcagatgaagaacaagcactcagagcagccggag
cccgacatgatcaccatcttcatcggcacctggaacatgggtaacgccccccctcccaag
aagatcacgtcctggtttctctccaaggggcagggaaagacgcgggacgactctgcggac
tacatcccccatgacatttacgtgatcggcacccaagaggaccccctgagtgagaaggag
tggctggagatcctcaaacactccctgcaagaaatcaccagtgtgacttttaaaacagtc
gccatccacacgctctggaacatccgcatcgtggtgctggccaagcctgagcacgagaac
cggatcagccacatctgtactgacaacgtgaagacaggcattgcaaacacactggggaac
aagggagccgtgggggtgtcgttcatgttcaatggaacctccttagggttcgtcaacagc
cacttgacttcaggaagtgaaaagaaactcaggcgaaaccaaaactatatgaacattctc
cggttcctggccctgggcgacaagaagctgagtccctttaacatcactcaccgcttcacg
cacctcttctggtttggggatcttaactaccgtgtggatctgcctacctgggaggcagaa
accatcatccagaaaatcaagcagcagcagtacgcagacctcctgtcccacgaccagctg
ctcacagagaggagggagcagaaggtcttcctacacttcgaggaggaagaaatcacgttt
gccccaacctaccgttttgagagactgactcgggacaaatacgcctacaccaagcagaaa
gcgacagggatgaagtacaacttgccttcctggtgtgaccgagtcctctggaagtcttat
cccctggtgcacgtggtgtgtcagtcttatggcagtaccagcgacatcatgacgagtgac
cacagccctgtctttgccacatttgaggcaggagtcacttcccagtttgtctccaagaac
ggtcccgggactgttgacagccaaggacagattgagtttctcaggtgctatgccacattg
aagaccaagtcccagaccaaattctacctggagttccactcgagctgcttggagagtttt
gtcaagagtcaggaaggagaaaatgaagaaggaagtgagggggagctggtggtgaagttt
ggtgagactcttccaaagctgaagcccattatctctgaccctgagtacctgctagaccag
cacatcctcatcagcatcaagtcctctgacagcgacgaatcctatggcgagggctgcatt
gcccttcggttagaggccacagaaacgcagctgcccatctacacgcctctcacccaccat
ggggagttgacaggccacttccagggggagatcaagctgcagacctctcagggcaagacg
agggagaagctctatgactttgtgaagacggagcgtgatgaatccagtgggccaaagacc
ctgaagagcctcaccagccacgaccccatgaagcagtgggaagtcactagcagggcccct
ccgtgcagtggctccagcatcactgaaatcatcaaccccaactacatgggagtggggccc
tttgggccaccaatgcccctgcacgtgaagcagaccttgtcccctgaccagcagcccaca
gcctggagctacgaccagccgcccaaggactccccgctggggccctgcaggggagaaagt
cctccgacacctcccggccagccgcccatatcacccaagaagtttttaccctcaacagca
aaccggggtctccctcccaggacacaggagtcaaggcccagtgacctggggaagaacgca
ggggacacgctgcctcaggaggacctgccgctgacgaagcccgagatgtttgagaacccc
ctgtatgggtccctgagttccttccctaagcctgctcccaggaaggaccaggaatccccc
aaaatgccgcggaaggaacccccgccctgcccggaacccggcatcttgtcgcccagcatc
gtgctcaccaaagcccaggaggctgatcgcggcgaggggcccggcaagcaggtgcccgcg
ccccggctgcgctccttcacgtgctcatcctctgccgagggcagggcggccggcggggac
aagagccaagggaagcccaagaccccggtcagctcccaggccccggtgccggccaagagg
cccatcaagccttccagatcggaaatcaaccagcagaccccgcccaccccgacgccgcgg
ccgccgctgccagtcaagagcccggcggtgctgcacctccagcactccaagggccgcgac
taccgcgacaacaccgagctcccgcatcacggcaagcaccggccggaggaggggccacca
gggcctctaggcaggactgccatgcagtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (31)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (42)   
   RefSeq(nuc) (8)   
   GenBank (17)   
   EMBL (17)   
3D Structure (98)   
   PDB (98)   
Protein domain (1)   
   Pfam (1)   
All databases (209)   

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