KEGG   Homo sapiens (human): 3656
Entry
3656              CDS       T01001                                 
Symbol
IRAK2, IRAK-2
Name
(RefSeq) interleukin 1 receptor associated kinase 2
  KO
K04731  interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04722  Neurotrophin signaling pathway
hsa05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    3656 (IRAK2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3656 (IRAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3656 (IRAK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     3656 (IRAK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  IRAK family
   3656 (IRAK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Death
Other DBs
NCBI-GeneID: 3656
NCBI-ProteinID: NP_001561
OMIM: 603304
HGNC: 6113
Ensembl: ENSG00000134070
UniProt: O43187
Structure
Position
3:10164919..10243745
AA seq 625 aa
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITREL
LWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASV
RKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLR
ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQG
QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS
PVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACL
CLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDAS
SSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINE
AKRKLMENILLYKEEKVDSIELFGP
NT seq 1878 nt   +upstreamnt  +downstreamnt
atggcctgctacatctaccagctgccctcctgggtgctggacgacctgtgccgcaacatg
gacgcgctcagcgagtgggactggatggagttcgcctcctacgtgatcacagacctgacc
cagctgcggaagatcaagtccatggagcgggtgcagggtgtgagcatcacgcgggagctg
ctgtggtggtggggcatgcggcaggccaccgtccagcaacttgtggacctcctgtgccgc
ctggagctctaccgggctgcccagatcatcctgaactggaaaccggctcctgaaatcagg
tgtcccattccagccttccctgactctgtgaagccagaaaagcctttggcagcttctgta
agaaaggctgaggatgaacaggaagaggggcagcctgtgaggatggccacctttccaggc
ccagggtcctctccagccagagcccaccagccggcctttctccagcctcctgaagaagat
gcccctcattccttgagaagcgacctccccacttcgtctgattcaaaggacttcagcacc
tccattcctaagcaggaaaaacttttgagcttggctggagacagccttttctggagtgag
gcagacgtggtccaggcaaccgatgacttcaatcaaaaccgcaaaatcagccaggggacc
tttgctgacgtctacagagggcacaggcacgggaagccattcgtcttcaagaagctcaga
gagacagcctgttcaagtccaggatcaatcgaaagattcttccaggcagagttgcagatt
tgtcttagatgctgccaccccaatgtcttacctgtgctgggcttctgtgctgcaagacag
tttcacagcttcatctacccctacatggcaaatggttccctacaggacagactgcagggt
cagggtggctcggaccccctcccctggccccagcgtgtcagcatctgctcagggctgctc
tgtgccgtcgagtacctgcatggtctggagatcatccacagcaacgtcaagagctctaat
gtcttgctggaccaaaatctcacccccaaacttgctcacccaatggctcatctgtgtcct
gtcaacaaaaggtcaaaatacaccatgatgaagactcacctgctccggacgtcagccgcg
tatctgccagaggatttcatccgggtggggcagctgacaaagcgagtggacatcttcagc
tgtggaatagtgttggccgaggtcctcacgggcatccctgcaatggataacaaccgaagc
ccggtttacctgaaggacttactcctcagtgatattccaagcagcaccgcctcgctctgc
tccaggaagacgggcgtggagaacgtgatggcaaaggagatctgccagaagtacctggag
aagggcgcagggaggcttccggaggactgcgccgaggccctggccacggctgcctgcctg
tgcctgcggaggcgtaacaccagcctgcaggaggtgtgtggctctgtggctgctgtggaa
gagcggctccgaggtcgggagacgttgctcccttggagtgggctttctgagggtacaggc
tcttcttccaacaccccagaggaaacagacgacgttgacaattccagccttgatgcctcc
tcctccatgagtgtggcaccctgggcaggggctgccaccccacttctccccacagagaat
ggggaaggaaggctgcgggtcatcgtgggaagggaggctgactcctcctctgaggcctgt
gttggcctggagcctccccaggatgttacagaaacttcgtggcaaattgagatcaatgag
gccaaaaggaaactgatggagaatattctgctctacaaagaggaaaaagtggacagcatt
gagctctttggcccctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (49)   

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