KEGG   Homo sapiens (human): 3667
Entry
3667              CDS       T01001                                 
Symbol
IRS1, HIRS-1
Name
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04068  FoxO signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05010  Alzheimer disease
hsa05206  MicroRNAs in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06325  Hormone/cytokine signaling
  Element
N01708  INS-AKT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    3667 (IRS1)
   04022 cGMP-PKG signaling pathway
    3667 (IRS1)
   04151 PI3K-Akt signaling pathway
    3667 (IRS1)
   04152 AMPK signaling pathway
    3667 (IRS1)
   04150 mTOR signaling pathway
    3667 (IRS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    3667 (IRS1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    3667 (IRS1)
   04923 Regulation of lipolysis in adipocytes
    3667 (IRS1)
   04920 Adipocytokine signaling pathway
    3667 (IRS1)
   04935 Growth hormone synthesis, secretion and action
    3667 (IRS1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3667 (IRS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    3667 (IRS1)
  09149 Aging
   04211 Longevity regulating pathway
    3667 (IRS1)
   04213 Longevity regulating pathway - multiple species
    3667 (IRS1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    3667 (IRS1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3667 (IRS1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    3667 (IRS1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    3667 (IRS1)
   04932 Non-alcoholic fatty liver disease
    3667 (IRS1)
   04931 Insulin resistance
    3667 (IRS1)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 3667
NCBI-ProteinID: NP_005535
OMIM: 147545
HGNC: 6125
Ensembl: ENSG00000169047
UniProt: P35568
Structure
Position
2:complement(226731312..226799820)
AA seq 1242 aa
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES
SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE
FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV
EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN
RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR
HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ
PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
NT seq 3729 nt   +upstreamnt  +downstreamnt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac
cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc
ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc
aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc
ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc
agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc
cgccgatcacgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag
ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc
tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc
cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt
tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac
ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccgc
tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc
ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccagtggccgaaagggcagtggagactatatgcccatgagccccaagagcgta
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc
agcagcagcagcagcagcaacgccgtcccttccgggaccagctatggaaagctgtggaca
aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc
agcggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggac
tccaacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagcca
gtcctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccg
gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat
gctgcaacagcagatgattcttcctcttccaccagcagcgacagcctgggtgggggatac
tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat
ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgagg
ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag
cagcagcccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaa
tttgggagtgatcagtctggctacttgtctggcccggtggctttccacagctcaccttct
gtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggag
tacatgaagatggacctggggccgggccggagggcagcctggcaggagagcactggggtc
gagatgggcagactgggccctgcacctcccggggctgctagcatttgcaggcctacccgg
gcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagc
tacgtggacacctcgccagctgcccctgtaagctatgctgacatgcgaacaggcattgct
gcagaggaggtgagcctgcccagggccaccatggctgctgcctcctcatcctcagcagcc
tctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctg
gggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaac
cgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagc
tccgagactttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttgga
gcgggggcagcagtagggggcggtggcggtagcagcagcagcagcgaggatgtgaaacgc
cacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagccccc
aaggagccagccaaactgtgtggggctgctgggggtttggagaatggtcttaactacata
gacctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcag
cctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgc
cgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggac
cgtcagtag

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (20)   
   KEGG PATHWAY (20)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
3D Structure (8)   
   PDB (8)   
Protein domain (3)   
   Pfam (3)   
All databases (81)   

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