KEGG   Homo sapiens (human): 369
Entry
369               CDS       T01001                                 
Symbol
ARAF, A-RAF, ARAF1, PKS2, RAFA1
Name
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04068  FoxO signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04650  Natural killer cell mediated cytotoxicity
hsa04720  Long-term potentiation
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06210  ERK signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06324  GHRH-GH-IGF signaling
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06526  MAPK signaling
  Element
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to ERK signaling pathway
N00078  Mutation-activated HRAS to ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N00518  HCV Core to ERK signaling pathway
N00538  Ca2+-PYK2-RAS-ERK signaling pathway
N00540  HBV HBx to RAS-ERK signaling pathway
N00546  CXCL12-CXCR4-PKC-ERK signaling pathaway
N00744  IAV HA to ERK signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01062  Mutation-activated MET to RAS-ERK signaling pathway
N01064  Mutation-activated RET to RAS-ERK signaling pathway
N01119  RAC/CDC42-PAK-ERK signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01354  BPA to RAS-ERK signaling pathway
N01360  P4-PR-RAS-ERK signaling pathway
N01361  P4/MPA to PR-RAS-ERK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H02425  Erdheim-Chester disease
Drug target
Tovorafenib: D12291
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    369 (ARAF)
   04012 ErbB signaling pathway
    369 (ARAF)
   04068 FoxO signaling pathway
    369 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    369 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    369 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    369 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    369 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    369 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    369 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    369 (ARAF)
   04720 Long-term potentiation
    369 (ARAF)
   04730 Long-term depression
    369 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    369 (ARAF)
   05205 Proteoglycans in cancer
    369 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    369 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    369 (ARAF)
   05212 Pancreatic cancer
    369 (ARAF)
   05225 Hepatocellular carcinoma
    369 (ARAF)
   05226 Gastric cancer
    369 (ARAF)
   05214 Glioma
    369 (ARAF)
   05221 Acute myeloid leukemia
    369 (ARAF)
   05220 Chronic myeloid leukemia
    369 (ARAF)
   05218 Melanoma
    369 (ARAF)
   05211 Renal cell carcinoma
    369 (ARAF)
   05219 Bladder cancer
    369 (ARAF)
   05215 Prostate cancer
    369 (ARAF)
   05213 Endometrial cancer
    369 (ARAF)
   05224 Breast cancer
    369 (ARAF)
   05223 Non-small cell lung cancer
    369 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    369 (ARAF)
   05160 Hepatitis C
    369 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    369 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    369 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    369 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    369 (ARAF)
   01522 Endocrine resistance
    369 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    369 (ARAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     369 (ARAF)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   369 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 369
NCBI-ProteinID: NP_001645
OMIM: 311010
HGNC: 646
Ensembl: ENSG00000078061
UniProt: P10398 A0A024R178
Structure
Position
X:47561205..47571908
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccccgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccggtagtagaggaggtagtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggatctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Network (93)   
   KEGG NETWORK (93)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (37)   
   RefSeq(nuc) (3)   
   GenBank (17)   
   EMBL (17)   
3D Structure (2)   
   PDB (2)   
Protein domain (10)   
   Pfam (10)   
All databases (211)   

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