KEGG   Homo sapiens (human): 3690
Entry
3690              CDS       T01001                                 
Symbol
ITGB3, BDPLT16, BDPLT2, BDPLT24, CD61, GP3A, GPIIIa, GT, GT2
Name
(RefSeq) integrin subunit beta 3
  KO
K06493  integrin beta 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03266  Virion - Herpesvirus
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04640  Hematopoietic cell lineage
hsa04810  Regulation of actin cytoskeleton
hsa04820  Cytoskeleton in muscle cells
hsa04919  Thyroid hormone signaling pathway
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06535  Efferocytosis
  Element
N00393  ITGA/B-RhoGAP-RhoA signaling pathway
N00394  HCMV gH to ITGA/B-RhoA signaling pathway
N00951  ITGA/B-RHOG-RAC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01070  ITGA/B-FAK-CDC42 signaling pathway
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01761  Activation of CRK-DOCK-Rac1 pathway
Disease
H00083  Allograft rejection
H00226  Glanzmann thrombasthenia
H01235  Bleeding disorder platelet-type
H01730  Myocardial infarction
H01740  Macrothrombocytopenia
Drug target
Abciximab: D02778
Cilengitide: D03497
Elarofiban: D03971
Eptifibatide: D06888<US>
Etaracizumab: D09342
Fluciclatide F 18: D09903
Lamifiban (DG01420): D04659 D04660
Lotrafiban hydrochloride: D04785
Maraciclatide: D09929
Orbofiban acetate: D05267
Roxifiban acetate: D05772
Sibrafiban: D05834
Tadocizumab: D06649
Tirofiban (DG00159): D01029<US> D08607
Xemilofiban hydrochloride: D06335
Zalunfiban (DG03167): D12051 D12163
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03266 Virion - Herpesvirus
    3690 (ITGB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3690 (ITGB3)
   04151 PI3K-Akt signaling pathway
    3690 (ITGB3)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3690 (ITGB3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3690 (ITGB3)
   04148 Efferocytosis
    3690 (ITGB3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3690 (ITGB3)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    3690 (ITGB3)
   04810 Regulation of actin cytoskeleton
    3690 (ITGB3)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3690 (ITGB3)
   04611 Platelet activation
    3690 (ITGB3)
   04613 Neutrophil extracellular trap formation
    3690 (ITGB3)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    3690 (ITGB3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3690 (ITGB3)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    3690 (ITGB3)
   05205 Proteoglycans in cancer
    3690 (ITGB3)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    3690 (ITGB3)
   05163 Human cytomegalovirus infection
    3690 (ITGB3)
   05165 Human papillomavirus infection
    3690 (ITGB3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3690 (ITGB3)
   05410 Hypertrophic cardiomyopathy
    3690 (ITGB3)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    3690 (ITGB3)
   05414 Dilated cardiomyopathy
    3690 (ITGB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3690 (ITGB3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3690 (ITGB3)
   04515 Cell adhesion molecules [BR:hsa04515]
    3690 (ITGB3)
   04090 CD molecules [BR:hsa04090]
    3690 (ITGB3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3690 (ITGB3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3690 (ITGB3)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3690 (ITGB3)
CD molecules [BR:hsa04090]
 Proteins
  3690 (ITGB3)
SSDB
Motif
Pfam: Integrin_beta Integrin_B_tail Integrin_b_cyt I-EGF_1 PSI_integrin EGF_2
Other DBs
NCBI-GeneID: 3690
NCBI-ProteinID: NP_000203
OMIM: 173470
HGNC: 6156
Ensembl: ENSG00000259207
UniProt: P05106
Structure
Position
17:47253827..47313743
AA seq 788 aa
MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLG
SPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRP
DDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFG
AFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSR
NRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCH
VGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLS
MDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDT
VSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGT
FECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFG
KITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLL
CSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRY
CRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDIL
VVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTF
TNITYRGT
NT seq 2367 nt   +upstreamnt  +downstreamnt
atgcgagcgcggccgcggccccggccgctctgggcgactgtgctggcgctgggggcgctg
gcgggcgttggcgtaggagggcccaacatctgtaccacgcgaggtgtgagctcctgccag
cagtgcctggctgtgagccccatgtgtgcctggtgctctgatgaggccctgcctctgggc
tcacctcgctgtgacctgaaggagaatctgctgaaggataactgtgccccagaatccatc
gagttcccagtgagtgaggcccgagtactagaggacaggcccctcagcgacaagggctct
ggagacagctcccaggtcactcaagtcagtccccagaggattgcactccggctccggcca
gatgattcgaagaatttctccatccaagtgcggcaggtggaggattaccctgtggacatc
tactacttgatggacctgtcttactccatgaaggatgatctgtggagcatccagaacctg
ggtaccaagctggccacccagatgcgaaagctcaccagtaacctgcggattggcttcggg
gcatttgtggacaagcctgtgtcaccatacatgtatatctccccaccagaggccctcgaa
aacccctgctatgatatgaagaccacctgcttgcccatgtttggctacaaacacgtgctg
acgctaactgaccaggtgacccgcttcaatgaggaagtgaagaagcagagtgtgtcacgg
aaccgagatgccccagagggtggctttgatgccatcatgcaggctacagtctgtgatgaa
aagattggctggaggaatgatgcatcccacttgctggtgtttaccactgatgccaagact
catatagcattggacggaaggctggcaggcattgtccagcctaatgacgggcagtgtcat
gttggtagtgacaatcattactctgcctccactaccatggattatccctctttggggctg
atgactgagaagctatcccagaaaaacatcaatttgatctttgcagtgactgaaaatgta
gtcaatctctatcagaactatagtgagctcatcccagggaccacagttggggttctgtcc
atggattccagcaatgtcctccagctcattgttgatgcttatgggaaaatccgttctaaa
gtagagctggaagtgcgtgacctccctgaagagttgtctctatccttcaatgccacctgc
ctcaacaatgaggtcatccctggcctcaagtcttgtatgggactcaagattggagacacg
gtgagcttcagcattgaggccaaggtgcgaggctgtccccaggagaaggagaagtccttt
accataaagcccgtgggcttcaaggacagcctgatcgtccaggtcacctttgattgtgac
tgtgcctgccaggcccaagctgaacctaatagccatcgctgcaacaatggcaatgggacc
tttgagtgtggggtatgccgttgtgggcctggctggctgggatcccagtgtgagtgctca
gaggaggactatcgcccttcccagcaggacgaatgcagcccccgggagggtcagcccgtc
tgcagccagcggggcgagtgcctctgtggtcaatgtgtctgccacagcagtgactttggc
aagatcacgggcaagtactgcgagtgtgacgacttctcctgtgtccgctacaagggggag
atgtgctcaggccatggccagtgcagctgtggggactgcctgtgtgactccgactggacc
ggctactactgcaactgtaccacgcgtactgacacctgcatgtccagcaatgggctgctg
tgcagcggccgcggcaagtgtgaatgtggcagctgtgtctgtatccagccgggctcctat
ggggacacctgtgagaagtgccccacctgcccagatgcctgcacctttaagaaagaatgt
gtggagtgtaagaagtttgaccggggagccctacatgacgaaaatacctgcaaccgttac
tgccgtgacgagattgagtcagtgaaagagcttaaggacactggcaaggatgcagtgaat
tgtacctataagaatgaggatgactgtgtcgtcagattccagtactatgaagattctagt
ggaaagtccatcctgtatgtggtagaagagccagagtgtcccaagggccctgacatcctg
gtggtcctgctctcagtgatgggggccattctgctcattggccttgccgccctgctcatc
tggaaactcctcatcaccatccacgaccgaaaagaattcgctaaatttgaggaagaacgc
gccagagcaaaatgggacacagccaacaacccactgtataaagaggccacgtctaccttc
accaatatcacgtaccggggcacttaa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (23)   
   KEGG PATHWAY (23)   
Network (14)   
   KEGG NETWORK (14)   
Disease (9)   
   KEGG DISEASE (5)   
   OMIM (4)   
Drug (19)   
   KEGG DRUG (19)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
3D Structure (97)   
   PDB (97)   
Protein domain (6)   
   Pfam (6)   
All databases (223)   

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