KEGG   Homo sapiens (human): 3752
Entry
3752              CDS       T01001                                 
Symbol
KCND3, BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
Name
(RefSeq) potassium voltage-gated channel subfamily D member 3
  KO
K04893  potassium voltage-gated channel Shal-related subfamily D member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa05017  Spinocerebellar ataxia
Network
nt06462  Spinocerebellar ataxia
  Element
N00974  Transport of potassium
N00975  Mutation-inactivated KCND3 to transport of potassium
Disease
H00063  Spinocerebellar ataxia (SCA)
H00728  Brugada syndrome
Drug target
Amifampridine: D10228 D10689<US>
Amiodarone (DG00204): D00636<JP/US> D02910
Bepridil (DG00333): D00631<JP> D07520
Butamben (DG02875): D00730
Clofilium phosphate: D03547
Dronedarone (DG00207): D02537 D03914<US>
Fampridine: D04127<US>
Nifekalant hydrochloride: D01856<JP>
Vernakalant: D06665
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    3752 (KCND3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3752 (KCND3)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, voltage-gated (Kv)
   3752 (KCND3)
SSDB
Motif
Pfam: Ion_trans DUF3399 BTB_2 Shal-type Ion_trans_2 BTB_3 PKD_channel
Other DBs
NCBI-GeneID: 3752
NCBI-ProteinID: NP_004971
OMIM: 605411
HGNC: 6239
Ensembl: ENSG00000171385
UniProt: Q9UK17
Structure
Position
1:complement(111770662..111989668)
AA seq 655 aa
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
NT seq 1968 nt   +upstreamnt  +downstreamnt
atggcggccggagttgcggcctggctgccttttgcccgggctgcggccatcgggtggatg
ccggtggccaactgccccatgcccctggccccggccgacaagaacaagcggcaggatgag
ctgattgtcctcaacgtgagtgggcggaggttccagacctggaggaccacgctggagcgc
tacccggacaccctgctgggcagcacggagaaggagttcttcttcaacgaggacaccaag
gagtacttcttcgaccgggaccccgaggtgttccgctgcgtgctcaacttctaccgcacg
gggaagctgcactacccgcgctacgagtgcatctctgcctacgacgacgagctggccttc
tacggcatcctcccggagatcatcggggactgctgctacgaggagtacaaggaccgcaag
agggagaacgccgagcggctcatggacgacaacgactcggagaacaaccaggagtccatg
ccctcgctcagcttccgccagaccatgtggcgggccttcgagaacccccacaccagcacg
ctggccctggtcttctactacgtgactggcttcttcatcgctgtctcggtcatcaccaac
gtggtggagacggtgccgtgcggcacggtcccgggcagcaaggagctgccgtgcggggag
cgctactcggtggccttcttctgcctggacacggcgtgcgtcatgatcttcaccgtggag
tacctcctgcggctcttcgcggctcccagccgctaccgcttcatccgcagcgtcatgagc
atcatcgacgtggtggccatcatgccctactacatcggtctggtcatgaccaacaacgag
gacgtgtccggcgccttcgtcacgctccgggtcttccgcgtcttcaggatcttcaagttt
tcccgccactcccagggcctgcggatcctgggctacacactgaagagctgtgcctccgaa
ctgggctttcttctcttctccctcaccatggccatcatcatctttgccactgtgatgttt
tatgccgagaagggctcctcggccagcaagttcacaagcatccctgcctcgttttggtac
accattgtcaccatgaccacactgggatacggagacatggtgcctaagacgattgcaggg
aagatcttcggctccatctgctccttgagtggcgtcctggtcattgccctgccagtccct
gtgattgtttccaactttagccggatttaccaccagaatcagagagctgataaacgcagg
gcacaaaagaaggcccgccttgccaggatccgtgtggccaaaacaggcagttcgaatgca
tacctgcacagcaagcgcaacgggctcctcaacgaggcgctggagctgacgggcacccca
gaagaggagcacatgggcaagaccacctcactcatcgagagccagcatcatcacctgctg
cactgcctggaaaaaaccactgggttgtcctatcttgtggatgatcccctgttatctgta
cgaacctccaccatcaagaaccacgagtttattgatgagcagatgtttgagcagaactgc
atggagagttcaatgcagaactacccatccacaagaagtccctcactgtccagccaccca
ggcctcactaccacctgctgctcccgtcgtagtaagaagaccacacacctgcccaattct
aacctgccagctactcgcctgcgcagcatgcaagagctcagcacgatccacatccagggc
agtgagcagccctccctcacaaccagtcgctccagccttaatttgaaagcagacgacgga
ctgagaccaaactgcaaaacatcccagatcaccacagccatcatcagcatccccactccc
ccagcgctaaccccagagggggaaagtcggccaccccctgccagcccaggccccaacacg
aacattccttccatagccagcaatgttgtcaaggtctccgccttgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (13)   
   KEGG DRUG (13)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (22)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (44)   
   RefSeq(nuc) (20)   
   GenBank (12)   
   EMBL (12)   
3D Structure (6)   
   PDB (6)   
Protein domain (7)   
   Pfam (7)   
All databases (117)   

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