KEGG   Homo sapiens (human): 3816
Entry
3816              CDS       T01001                                 
Symbol
KLK1, KLKR, Klk6, hK1
Name
(RefSeq) kallikrein 1
  KO
K01325  tissue kallikrein [EC:3.4.21.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Drug target
Gabexate (DG01400): D01672<JP> D08004
Rinvecalinase alfa: D12830
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    3816 (KLK1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    3816 (KLK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3816 (KLK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3816 (KLK1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.35  tissue kallikrein
     3816 (KLK1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   3816 (KLK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3816 (KLK1)
SSDB
Motif
Pfam: Trypsin Trypsin_2 DUF1986
Other DBs
NCBI-GeneID: 3816
NCBI-ProteinID: NP_002248
OMIM: 147910
HGNC: 6357
Ensembl: ENSG00000167748
UniProt: P06870 A0A1R3UCD2
Structure
Position
19:complement(50819146..50823787)
AA seq 262 aa
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
NT seq 789 nt   +upstreamnt  +downstreamnt
atgtggttcctggttctgtgcctcgccctgtccctgggggggactggtgctgcgcccccg
attcagtcccggattgtgggaggctgggagtgtgagcagcattcccagccctggcaggcg
gctctgtaccatttcagcactttccagtgtgggggcatcctggtgcaccgccagtgggtg
ctcacagctgctcattgcatcagcgacaattaccagctctggctgggtcgccacaacttg
tttgacgacgaaaacacagcccagtttgttcatgtcagtgagagcttcccacaccctggc
ttcaacatgagcctcctggagaaccacacccgccaagcagacgaggactacagccacgac
ctcatgctgctccgcctgacagagcctgctgataccatcacagatgctgtgaaggtcgtg
gagttgcccaccgaggaacccgaagtggggagcacctgtttggcttccggctggggcagc
atcgaaccagagaatttctcatttccagatgatctccagtgtgtggacctcaaaatcctg
cctaatgatgagtgcaaaaaagcccacgtccagaaggtgacagacttcatgctgtgtgtc
ggacacctggaaggtggcaaagacacctgtgtgggtgattcagggggcccgctgatgtgt
gatggtgtgctccaaggtgtcacatcatggggctacgtcccttgtggcacccccaataag
ccttctgtcgccgtcagagtgctgtcttatgtgaagtggatcgaggacaccatagcggag
aactcctga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (66)   

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