KEGG   Homo sapiens (human): 3832
Entry
3832              CDS       T01001                                 
Symbol
KIF11, EG5, HKSP, KNSL1, MCLMR, TRIP5
Name
(RefSeq) kinesin family member 11
  KO
K10398  kinesin family member 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
Disease
H01876  Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
Drug target
Ispinesib mesylate: D04640
Litronesib: D09636
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    3832 (KIF11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3832 (KIF11)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3832 (KIF11)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Spindle formation proteins
    3832 (KIF11)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3832 (KIF11)
SSDB
Motif
Pfam: Kinesin Microtub_bind Microtub_bd Gag_p17
Other DBs
NCBI-GeneID: 3832
NCBI-ProteinID: NP_004514
OMIM: 148760
HGNC: 6388
Ensembl: ENSG00000138160
UniProt: P52732
Structure
Position
10:92593130..92655395
AA seq 1056 aa
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
NT seq 3171 nt   +upstreamnt  +downstreamnt
atggcgtcgcagccaaattcgtctgcgaagaagaaagaggagaaggggaagaacatccag
gtggtggtgagatgcagaccatttaatttggcagagcggaaagctagcgcccattcaata
gtagaatgtgatcctgtacgaaaagaagttagtgtacgaactggaggattggctgacaag
agctcaaggaaaacatacacttttgatatggtgtttggagcatctactaaacagattgat
gtttaccgaagtgttgtttgtccaattctggatgaagttattatgggctataattgcact
atctttgcgtatggccaaactggcactggaaaaacttttacaatggaaggtgaaaggtca
cctaatgaagagtatacctgggaagaggatcccttggctggtataattccacgtaccctt
catcaaatttttgagaaacttactgataatggtactgaattttcagtcaaagtgtctctg
ttggagatctataatgaagagctttttgatcttcttaatccatcatctgatgtttctgag
agactacagatgtttgatgatccccgtaacaagagaggagtgataattaaaggtttagaa
gaaattacagtacacaacaaggatgaagtctatcaaattttagaaaagggggcagcaaaa
aggacaactgcagctactctgatgaatgcatactctagtcgttcccactcagttttctct
gttacaatacatatgaaagaaactacgattgatggagaagagcttgttaaaatcggaaag
ttgaacttggttgatcttgcaggaagtgaaaacattggccgttctggagctgttgataag
agagctcgggaagctggaaatataaatcaatccctgttgactttgggaagggtcattact
gcccttgtagaaagaacacctcatgttccttatcgagaatctaaactaactagaatcctc
caggattctcttggagggcgtacaagaacatctataattgcaacaatttctcctgcatct
ctcaatcttgaggaaactctgagtacattggaatatgctcatagagcaaagaacatattg
aataagcctgaagtgaatcagaaactcaccaaaaaagctcttattaaggagtatacggag
gagatagaacgtttaaaacgagatcttgctgcagcccgtgagaaaaatggagtgtatatt
tctgaagaaaattttagagtcatgagtggaaaattaactgttcaagaagagcagattgta
gaattgattgaaaaaattggtgctgttgaggaggagctgaatagggttacagagttgttt
atggataataaaaatgaacttgaccagtgtaaatctgacctgcaaaataaaacacaagaa
cttgaaaccactcaaaaacatttgcaagaaactaaattacaacttgttaaagaagaatat
atcacatcagctttggaaagtactgaggagaaacttcatgatgctgccagcaagctgctt
aacacagttgaagaaactacaaaagatgtatctggtctccattccaaactggatcgtaag
aaggcagttgaccaacacaatgcagaagctcaggatatttttggcaaaaacctgaatagt
ctgtttaataatatggaagaattaattaaggatggcagctcaaagcaaaaggccatgcta
gaagtacataagaccttatttggtaatctgctgtcttccagtgtctctgcattagatacc
attactacagtagcacttggatctctcacatctattccagaaaatgtgtctactcatgtt
tctcagatttttaatatgatactaaaagaacaatcattagcagcagaaagtaaaactgta
ctacaggaattgattaatgtactcaagactgatcttctaagttcactggaaatgatttta
tccccaactgtggtgtctatactgaaaatcaatagtcaactaaagcatattttcaagact
tcattgacagtggccgataagatagaagatcaaaaaaaggaactagatggctttctcagt
atactgtgtaacaatctacatgaactacaagaaaataccatttgttccttggttgagtca
caaaagcaatgtggaaacctaactgaagacctgaagacaataaagcagacccattcccag
gaactttgcaagttaatgaatctttggacagagagattctgtgctttggaggaaaagtgt
gaaaatatacagaaaccacttagtagtgtccaggaaaatatacagcagaaatctaaggat
atagtcaacaaaatgacttttcacagtcaaaaattttgtgctgattctgatggcttctca
caggaactcagaaattttaaccaagaaggtacaaaattggttgaagaatctgtgaaacac
tctgataaactcaatggcaacctggaaaaaatatctcaagagactgaacagagatgtgaa
tctctgaacacaagaacagtttatttttctgaacagtgggtatcttccttaaatgaaagg
gaacaggaacttcacaacttattggaggttgtaagccaatgttgtgaggcttcaagttca
gacatcactgagaaatcagatggacgtaaggcagctcatgagaaacagcataacattttt
cttgatcagatgactattgatgaagataaattgatagcacaaaatctagaacttaatgaa
accataaaaattggtttgactaagcttaattgctttctggaacaggatctgaaactggat
atcccaacaggtacgacaccacagaggaaaagttatttatacccatcaacactggtaaga
actgaaccacgtgaacatctccttgatcagctgaaaaggaaacagcctgagctgttaatg
atgctaaactgttcagaaaacaacaaagaagagacaattccggatgtggatgtagaagag
gcagttctggggcagtatactgaagaacctctaagtcaagagccatctgtagatgctggt
gtggattgttcatcaattggcggggttccatttttccagcataaaaaatcacatggaaaa
gacaaagaaaacagaggcattaacacactggagaggtctaaagtggaagaaactacagag
cacttggttacaaagagcagattacctctgcgagcccagatcaacctttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (29)   
   RefSeq(nuc) (1)   
   GenBank (14)   
   EMBL (14)   
3D Structure (61)   
   PDB (61)   
Protein domain (4)   
   Pfam (4)   
All databases (124)   

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