KEGG   Homo sapiens (human): 3902
Entry
3902              CDS       T01001                                 
Symbol
LAG3, CD223
Name
(RefSeq) lymphocyte activating 3
  KO
K06565  lymphocyte-activation gene 3 protein
Organism
hsa  Homo sapiens (human)
Drug target
Bavunalimab: D12317
Favezelimab: D12469
Ieramilimab: D12156
Relatlimab: D11350
Tuparstobart: D12480
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    3902 (LAG3)
CD molecules [BR:hsa04090]
 Proteins
  3902 (LAG3)
SSDB
Motif
Pfam: Ig_3 ig V-set Ig_2 I-set Ig_6 Trypan_PARP stn_TNFRSF12A TarH
Other DBs
NCBI-GeneID: 3902
NCBI-ProteinID: NP_002277
OMIM: 153337
HGNC: 6476
Ensembl: ENSG00000089692
UniProt: P18627
Structure
Position
12:6772520..6778455
AA seq 525 aa
MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAG
VTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRV
QLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLR
ASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWG
CILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTP
PGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGS
PGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERL
LGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLILGVLSLLLLVTGAFGFHLWRRQWRP
RRFSALEQGIHPPQAQSKIEELEQEPEPEPEPEPEPEPEPEPEQL
NT seq 1578 nt   +upstreamnt  +downstreamnt
atgtgggaggctcagttcctgggcttgctgtttctgcagccgctttgggtggctccagtg
aagcctctccagccaggggctgaggtcccggtggtgtgggcccaggagggggctcctgcc
cagctcccctgcagccccacaatccccctccaggatctcagccttctgcgaagagcaggg
gtcacttggcagcatcagccagacagtggcccgcccgctgccgcccccggccatcccctg
gcccccggccctcacccggcggcgccctcctcctgggggcccaggccccgccgctacacg
gtgctgagcgtgggtcccggaggcctgcgcagcgggaggctgcccctgcagccccgcgtc
cagctggatgagcgcggccggcagcgcggggacttctcgctatggctgcgcccagcccgg
cgcgcggacgccggcgagtaccgcgccgcggtgcacctcagggaccgcgccctctcctgc
cgcctccgtctgcgcctgggccaggcctcgatgactgccagccccccaggatctctcaga
gcctccgactgggtcattttgaactgctccttcagccgccctgaccgcccagcctctgtg
cattggttccggaaccggggccagggccgagtccctgtccgggagtccccccatcaccac
ttagcggaaagcttcctcttcctgccccaagtcagccccatggactctgggccctggggc
tgcatcctcacctacagagatggcttcaacgtctccatcatgtataacctcactgttctg
ggtctggagcccccaactcccttgacagtgtacgctggagcaggttccagggtggggctg
ccctgccgcctgcctgctggtgtggggacccggtctttcctcactgccaagtggactcct
cctgggggaggccctgacctcctggtgactggagacaatggcgactttacccttcgacta
gaggatgtgagccaggcccaggctgggacctacacctgccatatccatctgcaggaacag
cagctcaatgccactgtcacattggcaatcatcacagtgactcccaaatcctttgggtca
cctggatccctggggaagctgctttgtgaggtgactccagtatctggacaagaacgcttt
gtgtggagctctctggacaccccatcccagaggagtttctcaggaccttggctggaggca
caggaggcccagctcctttcccagccttggcaatgccagctgtaccagggggagaggctt
cttggagcagcagtgtacttcacagagctgtctagcccaggtgcccaacgctctgggaga
gccccaggtgccctcccagcaggccacctcctgctgtttctcatccttggtgtcctttct
ctgctccttttggtgactggagcctttggctttcacctttggagaagacagtggcgacca
agacgattttctgccttagagcaagggattcaccctccgcaggctcagagcaagatagag
gagctggagcaagaaccggagccggagccggagccggaaccggagcccgagcccgagccc
gagccggagcagctctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (17)   
   RefSeq(nuc) (3)   
   GenBank (7)   
   EMBL (7)   
3D Structure (5)   
   PDB (5)   
Protein domain (9)   
   Pfam (9)   
All databases (68)   

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