KEGG   Homo sapiens (human): 3931
Entry
3931              CDS       T01001                                 
Symbol
LCAT
Name
(RefSeq) lecithin-cholesterol acyltransferase
  KO
K00650  lecithin-cholesterol acyltransferase [EC:2.3.1.43]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa04979  Cholesterol metabolism
Disease
H00158  Lecithin:cholesterol acyltransferase deficiency
H02505  Atherosclerosis
Drug target
Elastase ES: D04268<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    3931 (LCAT)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    3931 (LCAT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.43  phosphatidylcholine---sterol O-acyltransferase
     3931 (LCAT)
SSDB
Motif
Pfam: LCAT Abhydrolase_6 Hydrolase_4 Abhydrolase_1 Ser_hydrolase LD_cluster2
Other DBs
NCBI-GeneID: 3931
NCBI-ProteinID: NP_000220
OMIM: 606967
HGNC: 6522
Ensembl: ENSG00000213398
UniProt: P04180 A0A140VK24
Structure
Position
16:complement(67939750..67944120)
AA seq 440 aa
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQL
EAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGV
QIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEY
YRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGS
IKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGR
DFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDP
VGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLG
AYRQGPPASPTASPEPPPPE
NT seq 1323 nt   +upstreamnt  +downstreamnt
atggggccgcccggctccccatggcagtgggtgacgctgctgctggggctgctgctccct
cctgccgcccccttctggctcctcaatgtgctcttccccccgcacaccacgcccaaggct
gagctcagtaaccacacacggcccgtcatcctcgtgcccggctgcctggggaatcagcta
gaagccaagctggacaaaccagatgtggtgaactggatgtgctaccgcaagacagaggac
ttcttcaccatctggctggatctcaacatgttcctaccccttggggtagactgctggatc
gataacaccagggttgtctacaaccggagctctgggctcgtgtccaacgcccctggtgtc
cagatccgcgtccctggctttggcaagacctactctgtggagtacctggacagcagcaag
ctggcagggtacctgcacacactggtgcagaacctggtcaacaatggctacgtgcgggac
gagactgtgcgcgccgccccctatgactggcggctggagcccggccagcaggaggagtac
taccgcaagctcgcagggctggtggaggagatgcacgctgcctatgggaagcctgtcttc
ctcattggccacagcctcggctgtctacacttgctctatttcctgctgcgccagccccag
gcctggaaggaccgctttattgatggcttcatctctcttggggctccctggggtggctcc
atcaagcccatgctggtcttggcctcaggtgacaaccagggcatccccatcatgtccagc
atcaagctgaaagaggagcagcgcataaccaccacctccccctggatgtttccctctcgc
atggcgtggcctgaggaccacgtgttcatttccacacccagcttcaactacacaggccgt
gacttccaacgcttctttgcagacctgcactttgaggaaggctggtacatgtggctgcag
tcacgtgacctcctggcaggactcccagcacctggtgtggaagtatactgtctttacggc
gtgggcctgcccacgccccgcacctacatctacgaccacggcttcccctacacggaccct
gtgggtgtgctctatgaggatggtgatgacacggtggcgacccgcagcaccgagctctgt
ggcctgtggcagggccgccagccacagcctgtgcacctgctgcccctgcacgggatacag
catctcaacatggtcttcagcaacctgaccctggagcacatcaatgccatcctgctgggt
gcctaccgccagggtccccctgcatccccgactgccagcccagagcccccgcctcctgaa
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (6)   
   PDB (6)   
Protein domain (6)   
   Pfam (6)   
All databases (62)   

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