KEGG   Homo sapiens (human): 3977
Entry
3977              CDS       T01001                                 
Symbol
LIFR, CD118, LIF-R, SJS2, STWS, SWS
Name
(RefSeq) LIF receptor subunit alpha
  KO
K05058  leukemia inhibitory factor receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04630  JAK-STAT signaling pathway
Network
nt06518  JAK-STAT signaling
  Element
N01556  IL6 family to Jak-STAT signaling pathway
Disease
H00462  Stuve-Wiedemann syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3977 (LIFR)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3977 (LIFR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    3977 (LIFR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3977 (LIFR)
   04090 CD molecules [BR:hsa04090]
    3977 (LIFR)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL6/12 receptor family
   3977 (LIFR)
CD molecules [BR:hsa04090]
 Proteins
  3977 (LIFR)
SSDB
Motif
Pfam: LIFR_D2 LIFR_N LIF-R_Ig-like fn3 EpoR_lig-bind Pur_ac_phosph_N IL6Ra-bind TMEM154
Other DBs
NCBI-GeneID: 3977
NCBI-ProteinID: NP_001121143
OMIM: 151443
HGNC: 6597
Ensembl: ENSG00000113594
UniProt: P42702 A8K1Z4
Structure
Position
5:complement(38474668..38608403)
AA seq 1097 aa
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
NGGGWSFTNFFQNKPND
NT seq 3294 nt   +upstreamnt  +downstreamnt
atgatggatatttacgtatgtttgaaacgaccatcctggatggtggacaataaaagaatg
aggactgcttcaaatttccagtggctgttatcaacatttattcttctatatctaatgaat
caagtaaatagccagaaaaagggggctcctcatgatttgaagtgtgtaactaacaatttg
caagtgtggaactgttcttggaaagcaccctctggaacaggccgtggtactgattatgaa
gtttgcattgaaaacaggtcccgttcttgttatcagttggagaaaaccagtattaaaatt
ccagctctttcacatggtgattatgaaataacaataaattctctacatgattttggaagt
tctacaagtaaattcacactaaatgaacaaaacgtttccttaattccagatactccagag
atcttgaatttgtctgctgatttctcaacctctacattatacctaaagtggaacgacagg
ggttcagtttttccacaccgctcaaatgttatctgggaaattaaagttctacgtaaagag
agtatggagctcgtaaaattagtgacccacaacacaactctgaatggcaaagatacactt
catcactggagttgggcctcagatatgcccttggaatgtgccattcattttgtggaaatt
agatgctacattgacaatcttcatttttctggtctcgaagagtggagtgactggagccct
gtgaagaacatttcttggatacctgattctcagactaaggtttttcctcaagataaagtg
atacttgtaggctcagacataacattttgttgtgtgagtcaagaaaaagtgttatcagca
ctgattggccatacaaactgccccttgatccatcttgatggggaaaatgttgcaatcaag
attcgtaatatttctgtttctgcaagtagtggaacaaatgtagtttttacaaccgaagat
aacatatttggaaccgttatttttgctggatatccaccagatactcctcaacaactgaat
tgtgagacacatgatttaaaagaaattatatgtagttggaatccaggaagggtgacagcg
ttggtgggcccacgtgctacaagctacactttagttgaaagtttttcaggaaaatatgtt
agacttaaaagagctgaagcacctacaaacgaaagctatcaattattatttcaaatgctt
ccaaatcaagaaatatataattttactttgaatgctcacaatccgctgggtcgatcacaa
tcaacaattttagttaatataactgaaaaagtttatccccatactcctacttcattcaaa
gtgaaggatattaattcaacagctgttaaactttcttggcatttaccaggcaactttgca
aagattaattttttatgtgaaattgaaattaagaaatctaattcagtacaagagcagcgg
aatgtcacaatcaaaggagtagaaaattcaagttatcttgttgctctggacaagttaaat
ccatacactctatatacttttcggattcgttgttctactgaaactttctggaaatggagc
aaatggagcaataaaaaacaacatttaacaacagaagccagtccttcaaaggggcctgat
acttggagagagtggagttctgatggaaaaaatttaataatctattggaagcctttaccc
attaatgaagctaatggaaaaatactttcctacaatgtatcgtgttcatcagatgaggaa
acacagtccctttctgaaatccctgatcctcagcacaaagcagagatacgacttgataag
aatgactacatcatcagcgtagtggctaaaaattctgtgggctcatcaccaccttccaaa
atagcgagtatggaaattccaaatgatgatctcaaaatagaacaagttgttgggatggga
aaggggattctcctcacctggcattacgaccccaacatgacttgcgactacgtcattaag
tggtgtaactcgtctcggtcggaaccatgccttatggactggagaaaagttccctcaaac
agcactgaaactgtaatagaatctgatgagtttcgaccaggtataagatataattttttc
ctgtatggatgcagaaatcaaggatatcaattattacgctccatgattggatatatagaa
gaattggctcccattgttgcaccaaattttactgttgaggatacttctgcagattcgata
ttagtaaaatgggaagacattcctgtggaagaacttagaggctttttaagaggatatttg
ttttactttggaaaaggagaaagagacacatctaagatgagggttttagaatcaggtcgt
tctgacataaaagttaagaatattactgacatatcccagaagacactgagaattgctgat
cttcaaggtaaaacaagttaccacctggtcttgcgagcctatacagatggtggagtgggc
ccggagaagagtatgtatgtggtgacaaaggaaaattctgtgggattaattattgccatt
ctcatcccagtggcagtggctgtcattgttggagtggtgacaagtatcctttgctatcgg
aaacgagaatggattaaagaaaccttctaccctgatattccaaatccagaaaactgtaaa
gcattacagtttcaaaagagtgtctgtgagggaagcagtgctcttaaaacattggaaatg
aatccttgtaccccaaataatgttgaggttctggaaactcgatcagcatttcctaaaata
gaagatacagaaataatttccccagtagctgagcgtcctgaagatcgctctgatgcagag
cctgaaaaccatgtggttgtgtcctattgtccacccatcattgaggaagaaataccaaac
ccagccgcagatgaagctggagggactgcacaggttatttacattgatgttcagtcgatg
tatcagcctcaagcaaaaccagaagaagaacaagaaaatgaccctgtaggaggggcaggc
tataagccacagatgcacctccccattaattctactgtggaagatatagctgcagaagag
gacttagataaaactgcgggttacagacctcaggccaatgtaaatacatggaatttagtg
tctccagactctcctagatccatagacagcaacagtgagattgtctcatttggaagtcca
tgctccattaattcccgacaatttttgattcctcctaaagatgaagactctcctaaatct
aatggaggagggtggtcctttacaaacttttttcagaacaaaccaaacgattaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (32)   
   RefSeq(nuc) (10)   
   GenBank (11)   
   EMBL (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (8)   
   Pfam (8)   
All databases (90)   

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