KEGG   Homo sapiens (human): 3981
Entry
3981              CDS       T01001                                 
Symbol
LIG4, LIG4S
Name
(RefSeq) DNA ligase 4
  KO
K10777  DNA ligase 4 [EC:6.5.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03450  Non-homologous end-joining
Network
nt06506  Double-strand break repair
  Element
N01445  Non-homologous end-joining
N01467  V(D)J recombination
Disease
H00094  Immunodeficiency associated with DNA repair defects
H02015  LIG4 syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03450 Non-homologous end-joining
    3981 (LIG4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    3981 (LIG4)
Enzymes [BR:hsa01000]
 6. Ligases
  6.5  Forming phosphoric-ester bonds
   6.5.1  Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
    6.5.1.1  DNA ligase (ATP)
     3981 (LIG4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    DNA Ligase 4 complex
     3981 (LIG4)
SSDB
Motif
Pfam: DNA_ligase_A_M DNA_ligase_A_N BRCT DNA_ligase_IV DNA_ligase_A_C BRCT_2 RNA_ligase mRNA_cap_enzyme ATG17_like
Other DBs
NCBI-GeneID: 3981
NCBI-ProteinID: NP_001091738
OMIM: 601837
HGNC: 6601
Ensembl: ENSG00000174405
UniProt: P49917
Structure
Position
13:complement(108207442..108218349)
AA seq 911 aa
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
NT seq 2736 nt   +upstreamnt  +downstreamnt
atggctgcctcacaaacttcacaaactgttgcatctcacgttccttttgcagatttgtgt
tcaactttagaacgaatacagaaaagtaaaggacgtgcagaaaaaatcagacacttcagg
gaatttttagattcttggagaaaatttcatgatgctcttcataagaaccacaaagatgtc
acagactctttttatccagcaatgagactaattcttcctcagctagaaagagagagaatg
gcctatggaattaaagaaactatgcttgctaagctttatattgagttgcttaatttacct
agagatggaaaagatgccctcaaacttttaaactacagaacacccactggaactcatgga
gatgctggagactttgcaatgattgcatattttgtgttgaagccaagatgtttacagaaa
ggaagtttaaccatacagcaagtaaacgaccttttagactcaattgccagcaataattct
gctaaaagaaaagacctaataaaaaagagccttcttcaacttataactcagagttcagca
cttgagcaaaagtggcttatacggatgatcataaaggatttaaagcttggtgttagtcag
caaactatcttttctgtttttcataatgatgctgctgagttgcataatgtcactacagat
ctggaaaaagtctgtaggcaactgcatgatccttctgtaggactcagtgatatttctatc
actttattttctgcatttaaaccaatgctagctgctattgcagatattgagcacattgag
aaggatatgaaacatcagagtttctacatagaaaccaagctagatggtgaacgtatgcaa
atgcacaaagatggagatgtatataaatacttctctcgaaatggatataactacactgat
cagtttggtgcttctcctactgaaggttctcttaccccattcattcataatgcattcaaa
gcagatatacaaatctgtattcttgatggtgagatgatggcctataatcctaatacacaa
actttcatgcaaaagggaactaagtttgatattaaaagaatggtagaggattctgatctg
caaacttgttattgtgtttttgatgtattgatggttaataataaaaagctagggcatgag
actctgagaaagaggtatgagattcttagtagtatttttacaccaattccaggtagaata
gaaatagtgcagaaaacacaagctcatactaagaatgaagtaattgatgcattgaatgaa
gcaatagataaaagagaagagggaattatggtaaaacaacctctatccatctacaagcca
gacaaaagaggtgaagggtggttaaaaattaaaccagagtatgtcagtggactaatggat
gaattggacattttaattgttggaggatattggggtaaaggatcacggggtggaatgatg
tctcattttctgtgtgcagtagcagagaagccccctcctggtgagaagccatctgtgttt
catactctctctcgtgttgggtctggctgcaccatgaaagaactgtatgatctgggtttg
aaattggccaagtattggaagccttttcatagaaaagctccaccaagcagcattttatgt
ggaacagagaagccagaagtatacattgaaccttgtaattctgtcattgttcagattaaa
gcagcagagatcgtacccagtgatatgtataaaactggctgcaccttgcgttttccacga
attgaaaagataagagatgacaaggagtggcatgagtgcatgaccctggacgacctagaa
caacttagggggaaggcatctggtaagctcgcatctaaacacctttatataggtggtgat
gatgaaccacaagaaaaaaagcggaaagctgccccaaagatgaagaaagttattggaatt
attgagcacttaaaagcacctaaccttactaacgttaacaaaatttctaatatatttgaa
gatgtagagttttgtgttatgagtggaacagatagccagccaaagcctgacctggagaac
agaattgcagaatttggtggttatatagtacaaaatccaggcccagacacgtactgtgta
attgcagggtctgagaacatcagagtgaaaaacataattttgtcaaataaacatgatgtt
gtcaagcctgcatggcttttagaatgttttaagaccaaaagctttgtaccatggcagcct
cgctttatgattcatatgtgcccatcaaccaaagaacattttgcccgtgaatatgattgc
tatggtgatagttatttcattgatacagacttgaaccaactgaaggaagtattctcagga
attaaaaattctaacgagcagactcctgaagaaatggcttctctgattgctgatttagaa
tatcggtattcctgggattgctctcctctcagtatgtttcgacgccacaccgtttatttg
gactcgtatgctgttattaatgacctgagtaccaaaaatgaggggacaaggttagctatt
aaagccttggagcttcggtttcatggagcaaaagtagtttcttgtttagctgagggagtg
tctcatgtaataattggggaagatcatagtcgtgttgcagattttaaagcttttagaaga
acttttaagagaaagtttaaaatcctaaaagaaagttgggtaactgattcaatagacaag
tgtgaattacaagaagaaaaccagtatttgatttaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (82)   
   RefSeq(nuc) (12)   
   GenBank (35)   
   EMBL (35)   
3D Structure (23)   
   PDB (23)   
Protein domain (9)   
   Pfam (9)   
All databases (159)   

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