KEGG   Homo sapiens (human): 3984
Entry
3984              CDS       T01001                                 
Symbol
LIMK1, LIMK, LIMK-1
Name
(RefSeq) LIM domain kinase 1
  KO
K05743  LIM domain kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
  Element
N00433  CXCR4-GNB/G-RAC signaling pathway
Disease
H01439  Williams-Beuren syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3984 (LIMK1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    3984 (LIMK1)
  09158 Development and regeneration
   04360 Axon guidance
    3984 (LIMK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    3984 (LIMK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    3984 (LIMK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3984 (LIMK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     3984 (LIMK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  LISK family [OT]
   3984 (LIMK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase LIM PDZ Kdo PDZ_6 ABC1 Haspin_kinase RIO1 PDZ_2 PknG_TPR
Other DBs
NCBI-GeneID: 3984
NCBI-ProteinID: NP_002305
OMIM: 601329
HGNC: 6613
Ensembl: ENSG00000106683
UniProt: P53667
Structure
Position
7:74083804..74122525
AA seq 647 aa
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
NT seq 1944 nt   +upstreamnt  +downstreamnt
atgaggttgacgctactttgttgcacctggagggaagaacgtatgggagaggaaggaagc
gagttgcccgtgtgtgcaagctgcggccagaggatctatgatggccagtacctccaggcc
ctgaacgcggactggcacgcagactgcttcaggtgttgtgactgcagtgcctccctgtcg
caccagtactatgagaaggatgggcagctcttctgcaagaaggactactgggcccgctat
ggcgagtcctgccatgggtgctctgagcaaatcaccaagggactggttatggtggctggg
gagctgaagtaccaccccgagtgtttcatctgcctcacgtgtgggacctttatcggtgac
ggggacacctacacgctggtggagcactccaagctgtactgcgggcactgctactaccag
actgtggtgacccccgtcatcgagcagatcctgcctgactcccctggctcccacctgccc
cacaccgtcaccctggtgtccatcccagcctcatctcatggcaagcgtggactttcagtc
tccattgaccccccgcacggcccaccgggctgtggcaccgagcactcacacaccgtccgc
gtccagggagtggatccgggctgcatgagcccagatgtgaagaattccatccacgtcgga
gaccggatcttggaaatcaatggcacgcccatccgaaatgtgcccctggacgagattgac
ctgctgattcaggaaaccagccgcctgctccagctgaccctcgagcatgaccctcacgat
acactgggccacgggctggggcctgagaccagccccctgagctctccggcttatactccc
agcggggaggcgggcagctctgcccggcagaaacctgtcttgaggagctgcagcatcgac
aggtctccgggcgctggctcactgggctccccggcctcccagcgcaaggacctgggtcgc
tctgagtccctccgcgtagtctgccggccacaccgcatcttccggccgtcggacctcatc
cacggggaggtgctgggcaagggctgcttcggccaggctatcaaggtgacacaccgtgag
acaggtgaggtgatggtgatgaaggagctgatccggttcgacgaggagacccagaggacg
ttcctcaaggaggtgaaggtcatgcgatgcctggaacaccccaacgtgctcaagttcatc
ggggtgctctacaaggacaagaggctcaacttcatcactgagtacatcaagggcggcacg
ctccggggcatcatcaagagcatggacagccagtacccatggagccagagagtgagcttt
gccaaggacatcgcatcagggatggcctacctccactccatgaacatcatccaccgagac
ctcaactcccacaactgcctggtccgcgagaacaagaatgtggtggtggctgacttcggg
ctggcgcgtctcatggtggacgagaagactcagcctgagggcctgcggagcctcaagaag
ccagaccgcaagaagcgctacaccgtggtgggcaacccctactggatggcacctgagatg
atcaacggccgcagctatgatgagaaggtggatgtgttctcctttgggatcgtcctgtgc
gagatcatcgggcgggtgaacgcagaccctgactacctgccccgcaccatggactttggc
ctcaacgtgcgaggattcctggaccgctactgccccccaaactgccccccgagcttcttc
cccatcaccgtgcgctgttgcgatctggaccccgagaagaggccatcctttgtgaagctg
gaacactggctggagaccctccgcatgcacctggccggccacctgccactgggcccacag
ctggagcagctggacagaggtttctgggagacctaccggcgcggcgagagcggactgcct
gcccaccctgaggtccccgactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (10)   
   PDB (10)   
Protein domain (11)   
   Pfam (11)   
All databases (74)   

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