KEGG   Homo sapiens (human): 3992
Entry
3992              CDS       T01001                                 
Symbol
FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12
Name
(RefSeq) fatty acid desaturase 1
  KO
K10224  acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01040  Biosynthesis of unsaturated fatty acids
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   01040 Biosynthesis of unsaturated fatty acids
    3992 (FADS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins [BR:hsa01004]
    3992 (FADS1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.44  acyl-CoA (8-3)-desaturase
     3992 (FADS1)
Lipid biosynthesis proteins [BR:hsa01004]
 Desaturase
  Front-end
   3992 (FADS1)
SSDB
Motif
Pfam: FA_desaturase Cyt-b5 Defensin_propep
Other DBs
NCBI-GeneID: 3992
NCBI-ProteinID: NP_037534
OMIM: 606148
HGNC: 3574
Ensembl: ENSG00000149485
UniProt: O60427 A0A0A0MR51
Position
11:complement(61799627..61817003)
AA seq 501 aa
MGTRAARPAGLPCGAENPARRRLALGARQQIHSWSPRTPSTRLTAPAGPARGVARPAMAP
DPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYA
GQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMG
LMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGH
LSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGK
ILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFY
VRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQAT
CNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAF
ADIIHSLKESGQLWLDAYLHQ
NT seq 1506 nt   +upstreamnt  +downstreamnt
atgggaacgcgcgctgcgaggcccgccggtctgccctgcggtgctgaaaacccggcgcgc
aggcggctggctctgggcgcgcgccagcaaatccactcctggagcccgcggaccccgagc
acgcgcctgacagcccctgctggcccggcgcgcggcgtcgccaggccagctatggccccc
gacccggtggccgccgagaccgcggctcagggacctaccccgcgctacttcacctgggac
gaggtggcccagcgctcagggtgcgaggagcggtggctagtgatcgaccgtaaggtgtac
aacatcagcgagttcacccgccggcatccagggggctcccgggtcatcagccactacgcc
gggcaggatgccacggatccctttgtggccttccacatcaacaagggccttgtgaagaag
tatatgaactctctcctgattggagaactgtctccagagcagcccagctttgagcccacc
aagaataaagagctgacagatgagttccgggagctgcgggccacagtggagcggatgggg
ctcatgaaggccaaccatgtcttcttcctgctgtacctgctgcacatcttgctgctggat
ggtgcagcctggctcaccctttgggtctttgggacgtcctttttgcccttcctcctctgt
gcggtgctgctcagtgcagttcaggcccaggctggctggctgcagcatgactttgggcac
ctgtcggtcttcagcacctcaaagtggaaccatctgctacatcattttgtgattggccac
ctgaagggggcccccgccagttggtggaaccacatgcacttccagcaccatgccaagccc
aactgcttccgcaaagacccagacatcaacatgcatcccttcttctttgccttggggaag
atcctctctgtggagcttgggaaacagaagaaaaaatatatgccgtacaaccaccagcac
aaatacttcttcctaattgggcccccagccttgctgcctctctacttccagtggtatatt
ttctattttgttatccagcgaaagaagtgggtggacttggcctggatgattaccttctac
gtccgcttcttcctcacttatgtgccactattggggctgaaagccttcctgggccttttc
ttcatagtcaggttcctggaaagcaactggtttgtgtgggtgacacagatgaaccatatt
cccatgcacattgatcatgaccggaacatggactgggtttccacccagctccaggccaca
tgcaatgtccacaagtctgccttcaatgactggttcagtggacacctcaacttccagatt
gagcaccatctttttcccacgatgcctcgacacaattaccacaaagtggctcccctggtg
cagtccttgtgtgccaagcatggcatagagtaccagtccaagcccctgctgtcagccttc
gccgacatcatccactcactaaaggagtcagggcagctctggctagatgcctatcttcac
caataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (45)   
   RefSeq(nuc) (5)   
   GenBank (20)   
   EMBL (20)   
Protein domain (3)   
   Pfam (3)   
All databases (98)   

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