KEGG   Homo sapiens (human): 4038
Entry
4038              CDS       T01001                                 
Symbol
LRP4, CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2
Name
(RefSeq) LDL receptor related protein 4
  KO
K20051  low-density lipoprotein receptor-related protein 4
Organism
hsa  Homo sapiens (human)
Network
nt06505  WNT signaling
  Element
N01441  Wnt signaling modulation, SOST/LRP4
Disease
H00486  Sclerosteosis
H00770  Congenital myasthenic syndrome
H00853  Cenani-Lenz syndactyly syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4038 (LRP4)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    4038 (LRP4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4038 (LRP4)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 Laminin domain-containing proteins
  Laminin EGF-like domain-containing proteins
   4038 (LRP4)
SSDB
Motif
Pfam: Ldl_recept_b Ldl_recept_a FXa_inhibition SGL cEGF DUF5050 EGF_CA
Other DBs
NCBI-GeneID: 4038
NCBI-ProteinID: NP_002325
OMIM: 604270
HGNC: 6696
Ensembl: ENSG00000134569
UniProt: O75096
Structure
Position
11:complement(46856717..46918550)
AA seq 1905 aa
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH
SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG
YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS
GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD
EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC
ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE
LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP
NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT
KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY
TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW
DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI
EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS
NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW
TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS
PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM
KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW
TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS
DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL
LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP
VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR
NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN
LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF
ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN
NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY
SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV
IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH
NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT
ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
NT seq 5718 nt   +upstreamnt  +downstreamnt
atgaggcggcagtggggcgcgctgctgcttggcgccctgctctgcgcacacggcctggcc
agcagccccgagtgtgcttgtggtcggagccacttcacatgtgcagtgagtgctcttgga
gagtgtacctgcatccctgcccagtggcagtgtgatggagacaatgactgcggggaccac
agcgatgaggatggatgtatactacctacctgttcccctcttgactttcactgtgacaat
ggcaagtgcatccgccgctcctgggtgtgtgacggggacaacgactgtgaggatgactcg
gatgagcaggactgtcccccccgggagtgtgaggaggacgagtttccctgccagaatggc
tactgcatccggagtctgtggcactgcgatggtgacaatgactgtggcgacaacagcgat
gagcagtgtgacatgcgcaagtgctccgacaaggagttccgctgtagtgacggaagctgc
attgctgagcattggtactgcgacggtgacaccgactgcaaagatggctccgatgaggag
aactgtccctcagcagtgccagcgcccccctgcaacctggaggagttccagtgtgcctat
ggacgctgcatcctcgacatctaccactgcgatggcgacgatgactgtggagactggtca
gacgagtctgactgctcctcccaccagccctgccgctctggggagttcatgtgtgacagt
ggcctgtgcatcaatgcaggctggcgctgcgatggtgacgcggactgtgatgaccagtct
gatgagcgcaactgcaccacctccatgtgtacggcagaacagttccgctgtcactcaggc
cgctgtgtccgcctgtcctggcgctgtgatggggaggacgactgtgcagacaacagcgat
gaagagaactgtgagaatacaggaagcccccaatgtgccttggaccagttcctgtgttgg
aatgggcgctgcattgggcagaggaagctgtgcaacggggtcaacgactgtggtgacaac
agcgacgaaagcccacagcagaattgccggccccggacgggtgaggagaactgcaatgtt
aacaacggtggctgtgcccagaagtgccagatggtgcggggggcagtgcagtgtacctgc
cacacaggctaccggctcacagaggatgggcacacgtgccaagatgtgaatgaatgtgcc
gaggaggggtattgcagccagggctgcaccaacagcgaaggggctttccaatgctggtgt
gaaacaggctatgaactacggcccgaccggcgcagctgcaaggctctggggccagagcct
gtgctgctgttcgccaatcgcatcgacatccggcaggtgctgccacaccgctctgagtac
acactgctgcttaacaacctggagaatgccattgcccttgatttccaccaccgccgcgag
cttgtcttctggtcagatgtcaccctggaccggatcctccgtgccaacctcaacggcagc
aacgtggaggaggttgtgtctactgggctggagagcccagggggcctggctgtggattgg
gtccatgacaaactctactggaccgactcaggcacctcgaggattgaggtggccaatctg
gatggggcccaccggaaagtgttgctgtggcagaacctggagaagccccgggccattgcc
ttgcatcccatggagggtaccatttactggacagactggggcaacaccccccgtattgag
gcctccagcatggatggctctggacgccgcatcattgccgatacccatctcttctggccc
aatggcctcaccatcgactatgccgggcgccgtatgtactgggtggatgctaagcaccat
gtcatcgagagggccaatctggatgggagtcaccgtaaggctgtcattagccagggcctc
ccgcatcccttcgccatcacagtgtttgaagacagcctgtactggacagactggcacacc
aagagcatcaatagcgctaacaaatttacggggaagaaccaggaaatcattcgcaacaaa
ctccacttccctatggacatccacaccttgcacccccagcgccaacctgcagggaaaaac
cgctgtggggacaacaacggaggctgcacgcacctgtgtctgcccagtggccagaactac
acctgtgcctgccccactggcttccgcaagatcagcagccacgcctgtgcccagagtctt
gacaagttcctgctttttgcccgaaggatggacatccgtcgaatcagctttgacacagag
gacctgtctgatgatgtcatcccactggctgacgtgcgcagtgctgtggcccttgactgg
gactcccgggatgaccacgtgtactggacagatgtcagcactgataccatcagcagggcc
aagtgggatggaacaggacaggaggtggtagtggataccagtttggagagcccagctggc
ctggccattgattgggtcaccaacaaactgtactggacagatgcaggtacagaccggatt
gaagtagccaacacagatggcagcatgagaacagtactcatctgggagaaccttgatcgt
cctcgggacatcgtggtggaacccatgggcgggtacatgtattggactgactggggtgcg
agccccaagattgaacgagctggcatggatgcctcaggccgccaagtcattatctcttct
aatctgacctggcctaatgggttagctattgattatgggtcccagcgtctatactgggct
gacgccggcatgaagacaattgaatttgctggactggatggcagtaagaggaaggtgctg
attggaagccagctcccccacccatttgggctgaccctctatggagagcgcatctattgg
actgactggcagaccaagagcatacagagcgctgaccggctgacagggctggaccgggag
actctgcaggagaacctggaaaacctaatggacatccatgtcttccaccgccgccggccc
ccagtgtctacaccatgtgctatggagaatggcggctgtagccacctgtgtcttaggtcc
ccaaatccaagcggattcagctgtacctgccccacaggcatcaacctgctgtctgatggc
aagacctgctcaccaggcatgaacagtttcctcatcttcgccaggaggatagacattcgc
atggtctccctggacatcccttattttgctgatgtggtggtaccaatcaacattaccatg
aagaacaccattgccattggagtagacccccaggaaggaaaggtgtactggtctgacagc
acactgcacaggatcagtcgtgccaatctggatggctcacagcatgaggacatcatcacc
acagggctacagaccacagatgggctcgcggttgatgccattggccggaaagtatactgg
acagacacgggaacaaaccggattgaagtgggcaacctggacgggtccatgcggaaagtg
ttggtgtggcagaaccttgacagtccccgggccatcgtactgtaccatgagatggggttt
atgtactggacagactggggggagaatgccaagttagagcggtccggaatggatggctca
gaccgcgcggtgctcatcaacaacaacctaggatggcccaatggactgactgtggacaag
gccagctcccaactgctatgggccgatgcccacaccgagcgaattgaggctgctgacctg
aatggtgccaatcggcatacattggtgtcaccggtgcagcacccatatggcctcaccctg
ctcgactcctatatctactggactgactggcagactcggagcatccaccgtgctgacaag
ggtactggcagcaatgtcatcctcgtgaggtccaacctgccaggcctcatggacatgcag
gctgtggaccgggcacagccactaggttttaacaagtgcggctcgagaaatggcggctgc
tcccacctctgcttgcctcggccttctggcttctcctgtgcctgccccactggcatccag
ctgaagggagatgggaagacctgtgatccctctcctgagacctacctgctcttctccagc
cgtggctccatccggcgtatctcactggacaccagtgaccacaccgatgtgcatgtccct
gttcctgagctcaacaatgtcatctccctggactatgacagcgtggatggaaaggtctat
tacacagatgtgttcctggatgttatcaggcgagcagacctgaacggcagcaacatggag
acagtgatcgggcgagggctgaagaccactgacgggctggcagtggactgggtggccagg
aacctgtactggacagacacaggtcgaaataccattgaggcgtccaggctggatggttcc
tgccgcaaagtactgatcaacaatagcctggatgagccccgggccattgctgttttcccc
aggaaggggtacctcttctggacagactggggccacattgccaagatcgaacgggcaaac
ttggatggttctgagcggaaggtcctcatcaacacagacctgggttggcccaatggcctt
accctggactatgatacccgcaggatctactgggtggatgcgcatctggaccggatcgag
agtgctgacctcaatgggaaactgcggcaggtcttggtcagccatgtgtcccaccccttt
gccctcacacagcaagacaggtggatctactggacagactggcagaccaagtcaatccag
cgtgttgacaaatactcaggccggaacaaggagacagtgctggcaaatgtggaaggactc
atggatatcatcgtggtttcccctcagcggcagacagggaccaatgcctgtggtgtgaac
aatggtggctgcacccacctctgctttgccagagcctcggacttcgtatgtgcctgtcct
gacgaacctgatagccggccctgctcccttgtgcctggcctggtaccaccagctcctagg
gctactggcatgagtgaaaagagcccagtgctacccaacacaccacctaccaccttgtat
tcttcaaccacccggacccgcacgtctctggaggaggtggaaggaagatgctctgaaagg
gatgccaggctgggcctctgtgcacgttccaatgacgctgttcctgctgctccaggggaa
ggacttcatatcagctacgccattggtggactcctcagtattctgctgattttggtggtg
attgcagctttgatgctgtacagacacaaaaaatccaagttcactgatcctggaatgggg
aacctcacctacagcaacccctcctaccgaacatccacacaggaagtgaagattgaagca
atccccaaaccagccatgtacaaccagctgtgctataagaaagagggagggcctgaccat
aactacaccaaggagaagatcaagatcgtagagggaatctgcctcctgtctggggatgat
gctgagtgggatgacctcaagcaactgcgaagctcacgggggggcctcctccgggatcat
gtatgcatgaagacagacacggtgtccatccaggccagctctggctccctggatgacaca
gagacggagcagctgttacaggaagagcagtctgagtgtagcagcgtccatactgcagcc
actccagaaagacgaggctctctgccagacacgggctggaaacatgaacgcaagctctcc
tcagagagccaggtctaa

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