KEGG   Homo sapiens (human): 4052
Entry
4052              CDS       T01001                                 
Symbol
LTBP1, ARCL2E
Name
(RefSeq) latent transforming growth factor beta binding protein 1
  KO
K19559  latent transforming growth factor beta binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04350  TGF-beta signaling pathway
Network
nt06507  TGFB signaling
  Element
N01460  Plasmin mediated activation of latent TGF-beta
Disease
H00557  Cutis laxa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    4052 (LTBP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    4052 (LTBP1)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 EGF-like domain-containing proteins
  hEGF / cEGF domain-containing proteins
   4052 (LTBP1)
SSDB
Motif
Pfam: EGF_CA cEGF TB EGF EGF_3 hEGF FXa_inhibition EGF_MSP1_1 Plasmod_Pvs28
Other DBs
NCBI-GeneID: 4052
NCBI-ProteinID: NP_996826
OMIM: 150390
HGNC: 6714
Ensembl: ENSG00000049323
UniProt: Q14766
Structure
Position
2:32946953..33399509
AA seq 1721 aa
MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNA
RYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHP
NPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKA
PGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAAS
SWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIH
HGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSI
CKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQ
CPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPP
NIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSH
QQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKK
PSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLP
GTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEP
VEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPV
VIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCIC
YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDE
CLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSY
QCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDI
DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEG
SFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTC
QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFC
DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY
SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGW
GDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGF
CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD
ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM
QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL
QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK
CINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE
NT seq 5166 nt   +upstreamnt  +downstreamnt
atggcgggggcctggctcaggtgggggctcctgctctgggcagggctcctcgcgtcctcg
gcgcacggccggctgcggaggatcacctacgtggtgcacccgggccccggcctggcagcc
ggcgccttgcccctgagcgggcccccgcgttcgcggacattcaacgtcgcgctcaacgcc
aggtacagccgcagctcggcggctgccggcgcccccagccgtgcctcccccggggtcccc
tcggagaggacccggcgcacgagcaagccgggcggcgcggccctgcaggggctcagaccg
ccgccgccgccgccgccggagcctgcgcgtcccgcggtccccggcgggcagctccacccc
aatcccggcggccacccggcagccgccccgttcaccaaacaaggcaggcaagttgtgcgc
tccaaggtgccgcaggagacccagagcggcggaggctctaggctgcaggttcaccagaag
cagcagctgcagggggtcaatgtctgtggagggcggtgctgtcatggctggagtaaggcc
cctggctcccagaggtgcaccaaacctagctgtgttccgccatgtcagaatggagggatg
tgtctccggccacaactctgtgtgtgtaaaccagggaccaagggcaaagcctgtgaaaca
atagctgcccaggacacctcgtcaccagtctttggagggcagagtcctggggctgcttcc
tcgtggggccctcctgagcaagcagcaaagcatacttcatctaagaaggcagacactcta
ccaagagtcagccctgtggcccagatgaccttaaccctcaagccgaagccttcagtggga
ctcccccagcagatacattctcaagtgactcctctttcttcccagagtgtggtgattcac
catggccagacccaggaatacgtgctcaagcccaagtactttccagcccagaaggggatt
tcaggagagcagtccactgaaggttctttccctttaagatatgtgcaggatcaagttgcg
gcaccttttcagctgagtaaccacactggccgcatcaaggtggtctttactccgagcatc
tgtaaagtgacctgcaccaagggcagctgtcagaacagctgtgagaaggggaacaccacc
actctcattagtgagaatggtcatgctgccgacaccctgacggccacgaacttccgagtg
gtaatttgccatcttccatgtatgaatggtggccagtgcagttcaagggacaaatgtcag
tgccctccaaatttcacaggaaaactttgtcagatcccagtccatggtgccagcgtgcct
aaactttatcagcattcccagcagccaggcaaggcgttggggacgcatgtcatccattca
acacataccttgcctctgaccgtgactagccagcaaggagtcaaagtgaaatttcctcct
aacatagtcaatatccatgtgaaacatcctcctgaagcttccgtccagatacatcaggtt
tcaagaattgatggcccaacaggccagaagacaaaagaagctcaaccaggccaatcccaa
gtctcgtaccaagggcttcctgtccagaagacccagaccatacattccacatactcccac
cagcaggtcattcctcacgtctaccccgtggctgctaagacacagcttggccggtgcttc
caggaaaccattgggtcacagtgtggcaaagcgctccctggcctttcaaagcaagaggac
tgctgtggaactgtgggtacctcctggggctttaacaaatgccagaaatgccccaagaaa
ccatcttatcatggatacaaccaaatgatggaatgcctaccgggttataagcgggttaac
aacaccttttgccaagatattaatgaatgtcagctacaaggtgtatgccctaatggtgag
tgtttgaataccatgggcagctatcgatgtacctgcaaaataggatttgggccggatcct
accttttcaagttgtgttcctgatccccctgtgatctcggaagagaaagggccctgttac
cgacttgtcagttctggaagacagtgtatgcaccctctgtctgttcacctcaccaagcag
ctctgctgttgtagtgtgggcaaggcctggggcccacactgtgagaaatgtccccttcca
ggcacagctgcttttaaggaaatctgtcctggtggaatgggttatacggtttctggcgtt
catagacgcaggccaatccatcaccatgtaggtaaaggacctgtatttgtcaagccaaag
aacactcaacctgttgctaaaagtactcatcctccacctctcccagccaaggaagagcca
gtggaggccctgaccttctcccgggaacacgggccaggagtggcggagccagaagtggca
actgcaccccctgaaaaggaaataccttcattggatcaagagaaaaccaaacttgagcct
ggtcaaccccagctgtctccaggcatttccactattcatctgcatccacagtttccagta
gtgattgaaaaaacatcacctcctgtgcctgttgaagtagctcctgaagcttctacgtct
agtgccagccaagtgattgctcctactcaagtgacagaaatcaatgaatgtactgtgaac
cctgatatctgtggagcaggacactgcattaacctaccagtgagatatacctgtatatgc
tacgagggctacaggttcagtgaacaacagaggaaatgtgtggatattgatgagtgtact
caggtccaacacctctgctcccagggccgctgtgaaaacaccgagggaagtttcttgtgc
atttgcccagcaggatttatggccagtgaggagggtactaactgcatagatgttgacgaa
tgcctgaggccggacgtctgtggggaggggcactgtgtcaatactgtgggggccttccgg
tgtgaatactgtgacagcgggtaccgcatgactcagagaggccgttgtgaggatattgat
gaatgtttgaatccaagcacttgtccagatgagcagtgtgtgaattctcctggatcttac
cagtgcgttccctgcacagaaggattccgaggctggaatggacagtgccttgatgtggac
gagtgcctggaaccaaacgtctgcgcaaatggtgattgttccaaccttgaaggctcctac
atgtgttcatgccacaaaggctatacccggactccggaccacaagcactgtagagatatt
gatgaatgtcagcaagggaatctatgtgtaaacgggcagtgcaaaaataccgagggctcc
ttcaggtgcacctgtggacaggggtaccagctgtcggcagctaaagaccagtgtgaagac
attgatgaatgccagcaccgtcatctctgtgctcatgggcagtgcaggaacactgagggc
tcttttcaatgtgtgtgtgaccagggttacagagcatctgggcttggagaccactgtgaa
gatatcaatgaatgcttggaggacaagagtgtttgccagagaggagactgcattaatact
gcagggtcctatgattgtacttgtccggatggatttcagctagatgacaataaaacatgt
caagatattaatgaatgtgaacatccagggctctgtggtccgcaaggggagtgcctaaac
acagagggttctttccattgtgtctgccagcagggtttctcaatctctgcagatggccgt
acgtgtgaagatattgatgaatgtgtaaacaacactgtttgtgacagtcacgggttttgt
gacaatacagctggctccttccgctgcctctgttatcagggctttcaagccccacaggat
gggcaagggtgtgtggatgtgaatgaatgtgaactgctcagtggggtgtgtggtgaagcc
ttctgtgaaaacgtggaagggtccttcctgtgcgtgtgtgctgatgaaaaccaagagtac
agccccatgactgggcagtgccgctcccggacctccacagatttagatgtagatgtagat
caacccaaagaagaaaagaaagaatgctactataatctcaatgacgccagtctctgtgat
aatgtgttggcccccaatgtcacgaaacaagaatgctgctgtacatcaggcgtgggatgg
ggagataactgcgaaatcttcccctgcccggtcttgggaactgctgagttcactgaaatg
tgtcccaaagggaaaggttttgtgcctgctggagaatcatcttctgaagctggtggtgag
aactataaagatgcagatgaatgcctactttttggacaagaaatctgcaaaaatggtttc
tgtttgaacactcggcctgggtatgaatgctactgtaagcaagggacgtactatgatcct
gtgaaactgcagtgctttgatatggatgaatgtcaagaccccagtagttgtattgatggc
cagtgtgttaatacagagggctcttacaactgcttctgtactcaccccatggtcctggat
gcgtcagaaaaaagatgtatacgaccggctgagtcaaacgaacaaatagaagaaactgat
gtctaccaagatttgtgctgggaacatctgagtgatgaatacgtgtgtagccggcctctt
gtgggcaagcagacaacgtacactgagtgctgctgtctgtatggagaggcctggggcatg
cagtgtgccctctgccccctgaaggattcagatgactatgctcagctgtgtaacatcccc
gtgacgggacgccggcagccatatggacgggacgccttggttgacttcagtgaacagtat
actccagaagccgatccctacttcatccaagaccgttttctaaatagctttgaggagtta
caggctgaggaatgcggcatcctcaatggatgtgaaaatggtcgctgtgtgagggtccag
gaaggttacacctgcgattgctttgatgggtatcacttggatacggccaagatgacctgt
gtcgatgtaaatgaatgcgatgagttgaacaaccggatgtctctctgcaagaatgccaag
tgcattaacaccgatggttcctacaagtgtttgtgtctgccaggctacgtgccttctgac
aagccaaactactgcactccgttgaataccgccttgaatttagagaaagacagtgacctg
gagtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (68)   
   KEGG ORTHOLOGY (1)   
   RefGene (62)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (105)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (103)   
DNA sequence (145)   
   RefSeq(nuc) (103)   
   GenBank (21)   
   EMBL (21)   
3D Structure (1)   
   PDB (1)   
Protein domain (9)   
   Pfam (9)   
All databases (337)   

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