KEGG   Homo sapiens (human): 4170
Entry
4170              CDS       T01001                                 
Symbol
MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
Name
(RefSeq) MCL1 apoptosis regulator, BCL2 family member
  KO
K02539  myeloid leukemia cell differntiation protein MCL-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04630  JAK-STAT signaling pathway
hsa05206  MicroRNAs in cancer
Drug target
Murizatoclax: D11962
Navitoclax (DG03204): D09935 D09936
Omacetaxine mepesuccinate: D08956<US>
Tapotoclax: D11963
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    4170 (MCL1)
   04151 PI3K-Akt signaling pathway
    4170 (MCL1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    4170 (MCL1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    4170 (MCL1)
SSDB
Motif
Pfam: Bcl-2 Bcl-2_3
Other DBs
NCBI-GeneID: 4170
NCBI-ProteinID: NP_068779
OMIM: 159552
HGNC: 6943
Ensembl: ENSG00000143384
UniProt: Q07820
Structure
Position
1:complement(150574558..150579610)
AA seq 350 aa
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgtttggcctcaaaagaaacgcggtaatcggactcaacctctactgtgggggggccggc
ttgggggccggcagcggcggcgccacccgcccgggagggcgacttttggctacggagaag
gaggcctcggcccggcgagagatagggggaggggaggccggcgcggtgattggcggaagc
gccggcgcaagccccccgtccaccctcacgccagactcccggagggtcgcgcggccgccg
cccattggcgccgaggtccccgacgtcaccgcgacccccgcgaggctgcttttcttcgcg
cccacccgccgcgcggcgccgcttgaggagatggaagccccggccgctgacgccatcatg
tcgcccgaagaggagctggacgggtacgagccggagcctctcgggaagcggccggctgtc
ctgccgctgctggagttggtcggggaatctggtaataacaccagtacggacgggtcacta
ccctcgacgccgccgccagcagaggaggaggaggacgagttgtaccggcagtcgctggag
attatctctcggtaccttcgggagcaggccaccggcgccaaggacacaaagccaatgggc
aggtctggggccaccagcaggaaggcgctggagaccttacgacgggttggggatggcgtg
cagcgcaaccacgagacggccttccaaggcatgcttcggaaactggacatcaaaaacgaa
gacgatgtgaaatcgttgtctcgagtgatgatccatgttttcagcgacggcgtaacaaac
tggggcaggattgtgactctcatttcttttggtgcctttgtggctaaacacttgaagacc
ataaaccaagaaagctgcatcgaaccattagcagaaagtatcacagacgttctcgtaagg
acaaaacgggactggctagttaaacaaagaggctgggatgggtttgtggagttcttccat
gtagaggacctagaaggtggcatcaggaatgtgctgctggcttttgcaggtgttgctgga
gtaggagctggtttggcatatctaataagatag

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (41)   
   RefSeq(nuc) (3)   
   GenBank (19)   
   EMBL (19)   
3D Structure (125)   
   PDB (125)   
Protein domain (2)   
   Pfam (2)   
All databases (199)   

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