KEGG   Homo sapiens (human): 4199
Entry
4199              CDS       T01001                                 
Symbol
ME1, HUMNDME, MES
Name
(RefSeq) malic enzyme 1
  KO
K00029  malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00620  Pyruvate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa03320  PPAR signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    4199 (ME1)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    4199 (ME1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.40  malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
     4199 (ME1)
SSDB
Motif
Pfam: Malic_M malic Trimer_CC
Other DBs
NCBI-GeneID: 4199
NCBI-ProteinID: NP_002386
OMIM: 154250
HGNC: 6983
Ensembl: ENSG00000065833
UniProt: P48163
Structure
Position
6:complement(83210402..83431051)
AA seq 572 aa
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVK
NFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP
RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC
GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNC
LIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ
GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEE
MKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLT
TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV
RSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
NT seq 1719 nt   +upstreamnt  +downstreamnt
atggagcccgaagccccccgtcgccgccacacccatcagcgcggctacctgctgacacgg
aaccctcacctcaacaaggacttggcctttaccctggaagagagacagcaattgaacatt
catggattgttgccaccttccttcaacagtcaggagatccaggttcttagagtagtaaaa
aatttcgagcatctgaactctgactttgacaggtatcttctcttaatggatctccaagat
agaaatgaaaaactcttttatagagtgctgacatctgacattgagaaattcatgcctatt
gtttatactcccactgtgggtctggcttgccaacaatatagtttggtgtttcggaagcca
agaggtctctttattactatccacgatcgagggcatattgcttcagttctcaatgcatgg
ccagaagatgtcatcaaggccattgtggtgactgatggagagcgtattcttggcttggga
gaccttggctgtaatggaatgggcatccctgtgggtaaattggctctatatacagcttgc
ggagggatgaatcctcaagaatgtctgcctgtcattctggatgtgggaaccgaaaatgag
gagttacttaaagatccactctacattggactacggcagagaagagtaagaggttctgaa
tatgatgattttttggacgaattcatggaggcagtttcttccaagtatggcatgaattgc
cttattcagtttgaagattttgccaatgtgaatgcatttcgtctcctgaacaagtatcga
aaccagtattgcacattcaatgatgatattcaaggaacagcatctgttgcagttgcaggt
ctccttgcagctcttcgaataaccaagaacaaactgtctgatcaaacaatactattccaa
ggagctggagaggctgccctagggattgcacacctgattgtgatggccttggaaaaagaa
ggtttaccaaaagagaaagccatcaaaaagatatggctggttgattcaaaaggattaata
gttaagggacgtgcttccttaacacaagagaaagagaagtttgcccatgaacatgaagaa
atgaagaacctagaagccattgttcaagaaataaaaccaactgccctcataggagttgct
gcaattggtggtgcattctcagaacaaattctcaaagatatggctgccttcaatgaacgg
cctattatttttgctttgagtaatccaactagcaaagcagaatgttctgcagagcagtgc
tacaaaataaccaagggacgtgcaatttttgccagtggcagtccttttgatccagtcact
cttccaaatggacagaccctatatcctggccaaggcaacaattcctatgtgttccctgga
gttgctcttggtgttgtggcgtgtggattgaggcagatcacagataatattttcctcact
actgctgaggttatagctcagcaagtgtcagataaacacttggaagagggtcggctttat
cctcctttgaataccattagagatgtttctctgaaaattgcagaaaagattgtgaaagat
gcataccaagaaaagacagccacagtttatcctgaaccgcaaaacaaagaagcatttgtc
cgctcccagatgtatagtactgattatgaccagattctacctgattgttattcttggcct
gaagaggtgcagaaaatacagaccaaagttgaccagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (3)   
   Pfam (3)   
All databases (73)   

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