KEGG   Homo sapiens (human): 4224
Entry
4224              CDS       T01001                                 
Symbol
MEP1A, PPHA
Name
(RefSeq) meprin A subunit alpha
  KO
K01395  meprin A [EC:3.4.24.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04974  Protein digestion and absorption
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04974 Protein digestion and absorption
    4224 (MEP1A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4224 (MEP1A)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    4224 (MEP1A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.18  meprin A
     4224 (MEP1A)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   4224 (MEP1A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of epithelial cells
   4224 (MEP1A)
SSDB
Motif
Pfam: Astacin MAM TRAF-mep_MATH EGF
Other DBs
NCBI-GeneID: 4224
NCBI-ProteinID: NP_005579
OMIM: 600388
HGNC: 7015
Ensembl: ENSG00000112818
UniProt: Q16819
Structure
Position
6:46793389..46845984
AA seq 746 aa
MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDIL
LQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYI
IFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWW
DQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIG
QRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEV
DHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVV
WVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIY
LDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSG
YLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAIND
TVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLS
QTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGP
LEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLG
MVIGGTAGVIFLTFSIIAILSQRPRK
NT seq 2241 nt   +upstreamnt  +downstreamnt
atggcttggattagatccacttgcattctcttttttaccttgctttttgcccacatagca
gctgtaccgattaagtatcttcctgaagaaaatgtacatgatgcagattttggtgaacag
aaggatatttcagaaatcaatttagctgcaggcttggacctctttcaaggggacatcctc
ttgcagaaatccagaaatggcctgagagacccaaacaccaggtggacgttccccattcct
tacatcttggctgataatttggggctgaatgctaaaggagccattctgtatgcctttgag
atgttccgtctcaagtcctgtgtggatttcaagccctatgaaggagagagctcatatatc
atatttcaacagtttgatgggtgctggtctgaggttggtgaccaacatgtgggacagaac
atttccattggccaaggatgtgcctataaggccatcatagaacacgagatcctgcatgct
ttgggattttaccacgagcagtcaaggacggaccgggatgattatgtgaacatctggtgg
gaccaaattctttcaggttaccagcacaactttgacacctatgatgatagcttaatcaca
gacctcaatacaccctatgattatgagtctttgatgcactaccagcctttctcatttaac
aagaatgcaagtgttcccaccatcacagccaagatccctgagtttaactccattatcgga
cagcgcctggatttcagtgccattgatttagagaggctgaaccgaatgtacaattgcacc
acaactcacactcttttggaccactgtacttttgagaaggcaaacatctgtggaatgatt
cagggcaccagagatgacactgactgggcccatcaggacagtgctcaggctggagaagtg
gatcacaccttgttgggacaatgcacaggtgccggctacttcatgcagttcagcaccagc
tcggggtccgcggaagaggcagccctactggagtctcggattctttacccaaagaggaag
cagcagtgcctgcaatttttctataaaatgacgggaagtccttcagacagactcgttgtc
tgggtcaggagggatgacagcacaggcaatgttcgcaagttggtgaaggtgcagactttt
caaggagatgatgaccacaattggaaaattgcccatgtggtgctcaaagaggaacagaag
tttcgctaccttttccagggcacaaaaggcgaccctcagaactcaactgggggaatttac
ctagatgacatcactctgacagaaaccccctgccccacaggggtctggacagtccggaat
ttctcccaagtccttgagaacaccagcaaaggggacaagcttcagagccctcgattctac
aattcggagggatatggttttggggtaactttatacccaaatagcagagaaagctctggt
tacttgagacttgcttttcatgtgtgcagtggggagaacgatgctatcctggagtggccg
gtagaaaacagacaggtgataattaccatccttgaccaggagcctgatgtccggaacagg
atgtcctcaagcatggtgttcactacctcgaagtcgcacacatctccagcgataaatgac
actgtcatctgggacaggccgtccagggtgggaacctatcatacggactgtaattgtttt
agaagcatcgacttgggctggagtggtttcatttcccaccaaatgctgaaaaggaggagt
ttcctgaaaaatgatgacctcatcatatttgtggactttgaagatatcacccacctcagc
cagactgaagttcccactaaaggcaaaagactgagcccccaaggcctcattctccaaggc
caggagcagcaggtctccgaagaaggttcgggaaaggccatgttagaggaagccctacct
gtcagcctgagccaggggcagcccagccgacagaagcggtcggtggagaacacaggcccc
ctggaggaccataactggccacagtacttcagagacccatgtgacccaaacccttgccaa
aatgacggcatctgtgtgaacgtgaaggggatggcgagctgcaggtgcatctctggacat
gctttcttctacacgggggagcgctgtcaggccgtgcaggtgcacggcagtgtcctgggc
atggtgatcggaggcacggctggcgtgatcttcttgaccttctccatcatcgccatcctt
tcccaaaggccaaggaagtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (27)   
   RefSeq(nuc) (5)   
   GenBank (11)   
   EMBL (11)   
3D Structure (5)   
   PDB (5)   
Protein domain (4)   
   Pfam (4)   
All databases (67)   

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