KEGG   Homo sapiens (human): 4261
Entry
4261              CDS       T01001                                 
Symbol
CIITA, C2TA, CIITAIV, MHC2TA, NLRA
Name
(RefSeq) class II major histocompatibility complex transactivator
  KO
K08060  MHC class II transactivator [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04612  Antigen processing and presentation
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05340  Primary immunodeficiency
Disease
H00630  Rheumatoid arthritis
H00985  Bare lymphocyte syndrome type2
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    4261 (CIITA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    4261 (CIITA)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    4261 (CIITA)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    4261 (CIITA)
  09163 Immune disease
   05340 Primary immunodeficiency
    4261 (CIITA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4261 (CIITA)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    4261 (CIITA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     4261 (CIITA)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  TAF1 family
   4261 (CIITA)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   4261 (CIITA)
SSDB
Motif
Pfam: NACHT LRR_6 NLRC4_HD2 LRR_4 LRR_8 LRR_9
Other DBs
NCBI-GeneID: 4261
NCBI-ProteinID: NP_000237
OMIM: 600005
HGNC: 7067
Ensembl: ENSG00000179583
UniProt: P33076 A0A0B4J1S1 Q66X48
Position
16:10866206..10943021
AA seq 1130 aa
MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEE
EIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFK
HIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCS
TLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGL
WQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM
PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGIL
VEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLG
KAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAA
DEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRG
CTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD
RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAEL
AKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGAL
WLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAA
SVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL
TPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQ
QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKL
EFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETL
NLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQ
YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
NT seq 3393 nt   +upstreamnt  +downstreamnt
atgcgttgcctggctccacgccctgctgggtcctacctgtcagagccccaaggcagctca
cagtgtgccaccatggagttggggcccctagaaggtggctacctggagcttcttaacagc
gatgctgaccccctgtgcctctaccacttctatgaccagatggacctggctggagaagaa
gagattgagctctactcagaacccgacacagacaccatcaactgcgaccagttcagcagg
ctgttgtgtgacatggaaggtgatgaagagaccagggaggcttatgccaatatcgcggaa
ctggaccagtatgtcttccaggactcccagctggagggcctgagcaaggacattttcaag
cacataggaccagatgaagtgatcggtgagagtatggagatgccagcagaagttgggcag
aaaagtcagaaaagacccttcccagaggagcttccggcagacctgaagcactggaagcca
gctgagccccccactgtggtgactggcagtctcctagtgggaccagtgagcgactgctcc
accctgccctgcctgccactgcctgcgctgttcaaccaggagccagcctccggccagatg
cgcctggagaaaaccgaccagattcccatgcctttctccagttcctcgttgagctgcctg
aatctccctgagggacccatccagtttgtccccaccatctccactctgccccatgggctc
tggcaaatctctgaggctggaacaggggtctccagtatattcatctaccatggtgaggtg
ccccaggccagccaagtaccccctcccagtggattcactgtccacggcctcccaacatct
ccagaccggccaggctccaccagccccttcgctccatcagccactgacctgcccagcatg
cctgaacctgccctgacctcccgagcaaacatgacagagcacaagacgtcccccacccaa
tgcccggcagctggagaggtctccaacaagcttccaaaatggcctgagccggtggagcag
ttctaccgctcactgcaggacacgtatggtgccgagcccgcaggcccggatggcatccta
gtggaggtggatctggtgcaggccaggctggagaggagcagcagcaagagcctggagcgg
gaactggccaccccggactgggcagaacggcagctggcccaaggaggcctggctgaggtg
ctgttggctgccaaggagcaccggcggccgcgtgagacacgagtgattgctgtgctgggc
aaagctggtcagggcaagagctattgggctggggcagtgagccgggcctgggcttgtggc
cggcttccccagtacgactttgtcttctctgtcccctgccattgcttgaaccgtccgggg
gatgcctatggcctgcaggatctgctcttctccctgggcccacagccactcgtggcggcc
gatgaggttttcagccacatcttgaagagacctgaccgcgttctgctcatcctagacggc
ttcgaggagctggaagcgcaagatggcttcctgcacagcacgtgcggaccggcaccggcg
gagccctgctccctccgggggctgctggccggccttttccagaagaagctgctccgaggt
tgcaccctcctcctcacagcccggccccggggccgcctggtccagagcctgagcaaggcc
gacgccctatttgagctgtccggcttctccatggagcaggcccaggcatacgtgatgcgc
tactttgagagctcagggatgacagagcaccaagacagagccctgacgctcctccgggac
cggccacttcttctcagtcacagccacagccctactttgtgccgggcagtgtgccagctc
tcagaggccctgctggagcttggggaggacgccaagctgccctccacgctcacgggactc
tatgtcggcctgctgggccgtgcagccctcgacagcccccccggggccctggcagagctg
gccaagctggcctgggagctgggccgcagacatcaaagtaccctacaggaggaccagttc
ccatccgcagacgtgaggacctgggcgatggccaaaggcttagtccaacacccaccgcgg
gccgcagagtccgagctggccttccccagcttcctcctgcaatgcttcctgggggccctg
tggctggctctgagtggcgaaatcaaggacaaggagctcccgcagtacctagcattgacc
ccaaggaagaagaggccctatgacaactggctggagggcgtgccacgctttctggctggg
ctgatcttccagcctcccgcccgctgcctgggagccctactcgggccatcggcggctgcc
tcggtggacaggaagcagaaggtgcttgcgaggtacctgaagcggctgcagccggggaca
ctgcgggcgcggcagctgctggagctgctgcactgcgcccacgaggccgaggaggctgga
atttggcagcacgtggtacaggagctccccggccgcctctcttttctgggcacccgcctc
acgcctcctgatgcacatgtactgggcaaggccttggaggcggcgggccaagacttctcc
ctggacctccgcagcactggcatttgcccctctggattggggagcctcgtgggactcagc
tgtgtcacccgtttcagggctgccttgagcgacacggtggcgctgtgggagtccctgcag
cagcatggggagaccaagctacttcaggcagcagaggagaagttcaccatcgagcctttc
aaagccaagtccctgaaggatgtggaagacctgggaaagcttgtgcagactcagaggacg
agaagttcctcggaagacacagctggggagctccctgctgttcgggacctaaagaaactg
gagtttgcgctgggccctgtctcaggcccccaggctttccccaaactggtgcggatcctc
acggccttttcctccctgcagcatctggacctggatgcgctgagtgagaacaagatcggg
gacgagggtgtctcgcagctctcagccaccttcccccagctgaagtccttggaaaccctc
aatctgtcccagaacaacatcactgacctgggtgcctacaaactcgccgaggccctgcct
tcgctcgctgcatccctgctcaggctaagcttgtacaataactgcatctgcgacgtggga
gccgagagcttggctcgtgtgcttccggacatggtgtccctccgggtgatggacgtccag
tacaacaagttcacggctgccggggcccagcagctcgctgccagccttcggaggtgtcct
catgtggagacgctggcgatgtggacgcccaccatcccattcagtgtccaggaacacctg
caacaacaggattcacggatcagcctgagatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (52)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (48)   
DNA sequence (78)   
   RefSeq(nuc) (56)   
   GenBank (11)   
   EMBL (11)   
Protein domain (6)   
   Pfam (6)   
All databases (175)   

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