KEGG   Homo sapiens (human): 4293
Entry
4293              CDS       T01001                                 
Symbol
MAP3K9, MEKK9, MLK1, PRKE1
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 9
  KO
K04417  mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4293 (MAP3K9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4293 (MAP3K9)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4293 (MAP3K9)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4293 (MAP3K9)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr SH3_9 SH3_2 SH3_1 ABC1 Pkinase_fungal OmpH GvpL_GvpF
Other DBs
NCBI-GeneID: 4293
NCBI-ProteinID: NP_001271159
OMIM: 600136
HGNC: 6861
Ensembl: ENSG00000006432
UniProt: P80192 Q8NEB1
Structure
Position
14:complement(70722526..70809513)
AA seq 1104 aa
MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP
RSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEE
PTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPL
EEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSI
SECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH
VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR
LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP
ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST
VPLCRAELNTHRPAPYEIQQEFWS
NT seq 3315 nt   +upstreamnt  +downstreamnt
atggagccctccagagcgcttctcggctgcctagcgagcgccgccgctgccgccccgccg
ggggaggatggagcaggggccggggccgaggaggaggaggaggaggaggaggaggcggcg
gcggcggtgggccccggggagctgggctgcgacgcgccgctgccctactggacggccgtg
ttcgagtacgaggcggcgggcgaggacgagctgaccctgcggctgggcgacgtggtggag
gtgctgtccaaggactcgcaggtgtccggcgacgagggctggtggaccgggcagctgaac
cagcgggtgggcatcttccccagcaactacgtgaccccgcgcagcgccttctccagccgc
tgccagcccggcggcgaggaccccagttgctacccgcccattcagttgttagaaattgat
tttgcggagctcaccttggaagagattattggcatcgggggctttgggaaggtctatcgt
gctttctggataggggatgaggttgctgtgaaagcagctcgccacgaccctgatgaggac
atcagccagaccatagagaatgttcgccaagaggccaagctcttcgccatgctgaagcac
cccaacatcattgccctaagaggggtatgtctgaaggagcccaacctctgcttggtcatg
gagtttgctcgtggaggacctttgaatagagtgttatctgggaaaaggattcccccagac
atcctggtgaattgggctgtgcagattgccagagggatgaactacttacatgatgaggca
attgttcccatcatccaccgcgaccttaagtccagcaacatattgatcctccagaaggtg
gagaatggagacctgagcaacaagattctgaagatcactgattttggcctggctcgggaa
tggcaccgaaccaccaagatgagtgcggcagggacgtatgcttggatggcacccgaagtc
atccgggcctccatgttttccaaaggcagtgatgtgtggagctatggggtgctactttgg
gagttgctgactggtgaggtgccctttcgaggcattgatggcttagcagtcgcttatgga
gtggccatgaacaaactcgcccttcctattccttctacgtgcccagaaccttttgccaaa
ctcatggaagactgctggaatcctgatccccactcacgaccatctttcacgaatatcctg
gaccagctaaccaccatagaggagtctggtttctttgaaatgcccaaggactccttccac
tgcctgcaggacaactggaaacacgagattcaggagatgtttgaccaactcagggccaaa
gaaaaggaacttcgcacctgggaggaggagctgacgcgggctgcactgcagcagaagaac
caggaggaactgctgcggcgtcgggagcaggagctggccgagcgggagattgacatcctg
gaacgggagctcaacatcatcatccaccagctgtgccaggagaagccccgggtgaagaaa
cgcaagggcaagttcaggaagagccggctgaagctcaaggatggcaaccgcatcagcctc
ccttctgatttccagcacaagttcacggtgcaggcctcccctaccatggataaaaggaag
agtcttatcaacagccgctccagtcctcctgcaagccccaccatcattcctcgccttcga
gccatccagttgacaccaggtgaaagcagcaaaacctggggcaggagctcagtcgtccca
aaggaggaaggggaggaggaggagaagagggccccaaagaagaagggacggacgtggggg
ccagggacgcttggtcagaaggagcttgcctcgggagatgaaggatcccctcagagacgt
gagaaagctaatggtttaagtaccccatcagaatctccacatttccacttgggcctcaag
tccctggtagatggatataagcagtggtcgtccagtgcccccaacctggtgaagggccca
aggagtagcccggccctgccagggttcaccagccttatggagatggaggatgaggacagt
gaaggcccagggagtggagagagtcgcctacagcattcacccagccagtcctacctctgt
atcccattccctcgtggagaggatggcgatggcccctccagtgatggaatccatgaggag
cccaccccagtcaactcggccacgagtacccctcagctgacgccaaccaacagcctcaag
cggggcggtgcccaccaccgccgctgcgaggtggctctgctcggctgtggggctgttctg
gcagccacaggcctagggtttgacttgctggaagctggcaagtgccagctgcttcccctg
gaggagcctgagccaccagcccgggaggagaagaaaagacgggagggtctttttcagagg
tccagccgtcctcgtcggagcaccagccccccatcccgaaagcttttcaagaaggaggag
cccatgctgttgctaggagacccctctgcctccctgacgctgctctccctctcctccatc
tccgagtgcaactccacacgctccctgctgcgctccgacagcgatgaaattgtcgtgtat
gagatgccagtcagcccagtcgaggcccctcccctgagtccatgtacccacaaccccctg
gtcaatgtccgagtagagcgcttcaaacgagatcctaaccaatctctgactcccacccat
gtcaccctcaccaccccctcgcagcccagcagtcaccggcggactccttctgatggggcc
cttaagccagagactctcctagccagcaggagcccctccagcaatgggttgagccccagt
cctggagcaggaatgttgaaaacccccagtcccagccgagacccaggtgaattcccccgt
ctccctgaccccaatgtggtcttccccccaaccccaaggcgctggaacactcagcaggac
tctaccttggagagacccaagactctggagtttctgcctcggccgcgtccttctgccaac
cggcaacggctggacccttggtggtttgtgtcccccagccatgcccgcagcacctcccca
gccaacagctccagcacagagacgcccagcaacctggactcctgctttgctagcagtagc
agcactgtagaggagcggcctggacttccagccctgctcccgttccaggcagggccgctg
cccccgactgagcggacgctcctggacctggatgcagaggggcagagtcaggacagcacc
gtgccgctgtgcagagcggaactgaacacacacaggcctgccccttatgagatccagcag
gagttctggtcttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (40)   
   RefSeq(nuc) (12)   
   GenBank (14)   
   EMBL (14)   
3D Structure (2)   
   PDB (2)   
Protein domain (9)   
   Pfam (9)   
All databases (96)   

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