| Entry |
|
|---|
| Symbol |
KMT2A, ALL-1, ALL1, CXXC7, GAS7, HRX, HTRX, HTRX1, MLL, MLL1, MLL1A, TRX1, WDSTS
|
|---|
| Name |
(RefSeq) lysine methyltransferase 2A
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa05202 | Transcriptional misregulation in cancer |
|
|---|
| Network |
|
|---|
| Element |
| N00119 | MLL-AF4 fusion to transcriptional activation |
| N00120 | MLL-ENL fusion to transcriptional activation |
| N00290 | Mutation-inactivated MEN1 to transcription |
|
|---|
| Disease |
| H00001 | B-cell acute lymphoblastic leukemia |
| H00002 | T-cell acute lymphoblastic leukemia |
| H01879 | Wiedemann-Steiner syndrome |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
4297 (KMT2A)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
4297 (KMT2A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
4297 (KMT2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
4297 (KMT2A)
03036 Chromosome and associated proteins [BR:hsa03036]
4297 (KMT2A)
Enzymes [BR:hsa01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
4297 (KMT2A)
Transcription factors [BR:hsa03000]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
4297 (KMT2A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
4297 (KMT2A)
HMT complexes
MLL-HCF complex
4297 (KMT2A)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| Position |
11:118436492..118526832
|
|---|
| AA seq |
3969 aa
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAV
AAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSA
AIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKD
ISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSR
IIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSS
SPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPED
VGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSL
SISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFT
PGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKI
LIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTD
KRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKA
PQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVP
KTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNIL
STLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK
CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYT
CVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI
PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH
NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE
LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDL
IKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDC
EDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR
PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS
RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTS
RELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK
TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTV
KVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC
QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH
NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED
AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEG
LGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPT
VPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS
NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS
VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTP
SNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP
LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAI
TAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV
SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS
QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI
TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF
LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG
RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN
AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN |
|---|
| NT seq |
11910 nt +upstreamnt +downstreamnt
atggcgcacagctgtcggtggcgcttccccgcccgacccgggaccaccgggggcggcggc
ggcggggggcgccggggcctagggggcgccccgcggcaacgcgtcccggccctgctgctt
ccccccgggcccccggtcggcggtggcggccccggggcgcccccctcccccccggctgtg
gcggccgcggcggcggcggcgggaagcagcggggctggggttccagggggagcggccgcc
gcctcagcagcctcctcgtcgtccgcctcgtcttcgtcttcgtcatcgtcctcagcctct
tcagggccggccctgctccgggtgggcccgggcttcgacgcggcgctgcaggtctcggcc
gccatcggcaccaacctgcgccggttccgggccgtgtttggggagagcggcgggggaggc
ggcagcggagaggatgagcaattcttaggttttggctcagatgaagaagtcagagtgcga
agtcccacaaggtctccttcagttaaaactagtcctcgaaaacctcgtgggagacctaga
agtggctctgaccgaaattcagctatcctctcagatccatctgtgttttcccctctaaat
aaatcagagaccaaatctggagataagatcaagaagaaagattctaaaagtatagaaaag
aagagaggaagacctcccaccttccctggagtaaaaatcaaaataacacatggaaaggac
atttcagagttaccaaagggaaacaaagaagatagcctgaaaaaaattaaaaggacacct
tctgctacgtttcagcaagccacaaagattaaaaaattaagagcaggtaaactctctcct
ctcaagtctaagtttaagacagggaagcttcaaataggaaggaagggggtacaaattgta
cgacggagaggaaggcctccatcaacagaaaggataaagaccccttcgggtctcctcatt
aattctgaactggaaaagccccagaaagtccggaaagacaaggaaggaacacctccactt
acaaaagaagataagacagttgtcagacaaagccctcgaaggattaagccagttaggatt
attccttcttcaaaaaggacagatgcaaccattgctaagcaactcttacagagggcaaaa
aagggggctcaaaagaaaattgaaaaagaagcagctcagctgcagggaagaaaggtgaag
acacaggtcaaaaatattcgacagttcatcatgcctgttgtcagtgctatctcctcgcgg
atcattaagacccctcggcggtttatagaggatgaggattatgaccctccaattaaaatt
gcccgattagagtctacaccgaatagtagattcagtgccccgtcctgtggatcttctgaa
aaatcaagtgcagcttctcagcactcctctcaaatgtcttcagactcctctcgatctagt
agccccagtgttgatacctccacagactctcaggcttctgaggagattcaggtacttcct
gaggagcggagcgatacccctgaagttcatcctccactgcccatttcccagtccccagaa
aatgagagtaatgataggagaagcagaaggtattcagtgtcggagagaagttttggatct
agaacgacgaaaaaattatcaactctacaaagtgccccccagcagcagacctcctcgtct
ccacctccacctctgctgactccaccgccaccactgcagccagcctccagtatctctgac
cacacaccttggcttatgcctccaacaatccccttagcatcaccatttttgcctgcttcc
actgctcctatgcaagggaagcgaaaatctattttgcgagaaccgacatttaggtggact
tctttaaagcattctaggtcagagccacaatacttttcctcagcaaagtatgccaaagaa
ggtcttattcgcaaaccaatatttgataatttccgaccccctccactaactcccgaggac
gttggctttgcatctggtttttctgcatctggtaccgctgcttcagcccgattgttttcg
ccactccattctggaacaaggtttgatatgcacaaaaggagccctcttctgagagctcca
agatttactccaagtgaggctcactctagaatatttgagtctgtaaccttgcctagtaat
cgaacttctgctggaacatcttcttcaggagtatccaatagaaaaaggaaaagaaaagtg
tttagtcctattcgatctgaaccaagatctccttctcactccatgaggacaagaagtgga
aggcttagtagttctgagctctcacctctcacccccccgtcttctgtctcttcctcgtta
agcatttctgttagtcctcttgccactagtgccttaaacccaacttttacttttccttct
cattccctgactcagtctggggaatctgcagagaaaaatcagagaccaaggaagcagact
agtgctccggcagagccattttcatcaagtagtcctactcctctcttcccttggtttacc
ccaggctctcagactgaaagagggagaaataaagacaaggcccccgaggagctgtccaaa
gatcgagatgctgacaagagcgtggagaaggacaagagtagagagagagaccgggagaga
gaaaaggagaataagcgggagtcaaggaaagagaaaaggaaaaagggatcagaaattcag
agtagttctgctttgtatcctgtgggtagggtttccaaagagaaggttgttggtgaagat
gttgccacttcatcttctgccaaaaaagcaacagggcggaagaagtcttcatcacatgat
tctgggactgatattacttctgtgactcttggggatacaacagctgtcaaaaccaaaata
cttataaagaaagggagaggaaatctggaaaaaaccaacttggacctcggcccaactgcc
ccatccctggagaaggagaaaaccctctgcctttccactccttcatctagcactgttaaa
cattccacttcctccataggctccatgttggctcaggcagacaagcttccaatgactgac
aagagggttgccagcctcctaaaaaaggccaaagctcagctctgcaagattgagaagagt
aagagtcttaaacaaaccgaccagcccaaagcacagggtcaagaaagtgactcatcagag
acctctgtgcgaggaccccggattaaacatgtctgcagaagagcagctgttgcccttggc
cgaaaacgagctgtgtttcctgatgacatgcccaccctgagtgccttaccatgggaagaa
cgagaaaagattttgtcttccatggggaatgatgacaagtcatcaattgctggctcagaa
gatgctgaacctcttgctccacccatcaaaccaattaaacctgtcactagaaacaaggca
ccccaggaacctccagtaaagaaaggacgtcgatcgaggcggtgtgggcagtgtcccggc
tgccaggtgcctgaggactgtggtgtttgtactaattgcttagataagcccaagtttggt
ggtcgcaatataaagaagcagtgctgcaagatgagaaaatgtcagaatctacaatggatg
ccttccaaagcctacctgcagaagcaagctaaagctgtgaaaaagaaagagaaaaagtct
aagaccagtgaaaagaaagacagcaaagagagcagtgttgtgaagaacgtggtggactct
agtcagaaacctaccccatcagcaagagaggatcctgccccaaagaaaagcagtagtgag
cctcctccacgaaagcccgtcgaggaaaagagtgaagaagggaatgtctcggcccctggg
cctgaatccaaacaggccaccactccagcttccaggaagtcaagcaagcaggtctcccag
ccagcactggtcatcccgcctcagccacctactacaggaccgccaagaaaagaagttccc
aaaaccactcctagtgagcccaagaaaaagcagcctccaccaccagaatcaggtccagag
cagagcaaacagaaaaaagtggctccccgcccaagtatccctgtaaaacaaaaaccaaaa
gaaaaggaaaaaccacctccggtcaataagcaggagaatgcaggcactttgaacatcctc
agcactctctccaatggcaatagttctaagcaaaaaattccagcagatggagtccacagg
atcagagtggactttaaggaggattgtgaagcagaaaatgtgtgggagatgggaggctta
ggaatcttgacttctgttcctataacacccagggtggtttgctttctctgtgccagtagt
gggcatgtagagtttgtgtattgccaagtctgttgtgagcccttccacaagttttgttta
gaggagaacgagcgccctctggaggaccagctggaaaattggtgttgtcgtcgttgcaaa
ttctgtcacgtttgtggaaggcaacatcaggctacaaagcagctgctggagtgtaataag
tgccgaaacagctatcaccctgagtgcctgggaccaaactaccccaccaaacccacaaag
aagaagaaagtctggatctgtaccaagtgtgttcgctgtaagagctgtggatccacaact
ccaggcaaagggtgggatgcacagtggtctcatgatttctcactgtgtcatgattgcgcc
aagctctttgctaaaggaaacttctgccctctctgtgacaaatgttatgatgatgatgac
tatgagagtaagatgatgcaatgtggaaagtgtgatcgctgggtccattccaaatgtgag
aatctttcagatgagatgtatgagattctatctaatctgccagaaagtgtggcctacact
tgtgtgaactgtactgagcggcaccctgcagagtggcgactggcccttgaaaaagagctg
cagatttctctgaagcaagttctgacagctttgttgaattctcggactaccagccatttg
ctacgctaccggcaggctgccaagcctccagacttaaatcccgagacagaggagagtata
ccttcccgcagctcccccgaaggacctgatccaccagttcttactgaggtcagcaaacag
gatgatcagcagcctttagatctagaaggagtcaagaggaagatggaccaagggaattac
acatctgtgttggagttcagtgatgatattgtgaagatcattcaagcagccattaattca
gatggaggacagccagaaattaaaaaagccaacagcatggtcaagtccttcttcattcgg
caaatggaacgtgtttttccatggttcagtgtcaaaaagtccaggttttgggagccaaat
aaagtatcaagcaacagtgggatgttaccaaacgcagtgcttccaccttcacttgaccat
aattatgctcagtggcaggagcgagaggaaaacagccacactgagcagcctcctttaatg
aagaaaatcattccagctcccaaacccaaaggtcctggagaaccagactcaccaactcct
ctgcatcctcctacaccaccaattttgagtactgataggagtcgagaagacagtccagag
ctgaacccacccccaggcatagaagacaatagacagtgtgcgttatgtttgacttatggt
gatgacagtgctaatgatgctggtcgtttactatatattggccaaaatgagtggacacat
gtaaattgtgctttgtggtcagcggaagtgtttgaagatgatgacggatcactaaagaat
gtgcatatggctgtgatcaggggcaagcagctgagatgtgaattctgccaaaagccagga
gccaccgtgggttgctgtctcacatcctgcaccagcaactatcacttcatgtgttcccga
gccaagaactgtgtctttctggatgataaaaaagtatattgccaacgacatcgggatttg
atcaaaggcgaagtggttcctgagaatggatttgaagttttcagaagagtgtttgtggac
tttgaaggaatcagcttgagaaggaagtttctcaatggcttggaaccagaaaatatccac
atgatgattgggtctatgacaatcgactgcttaggaattctaaatgatctctccgactgt
gaagataagctctttcctattggatatcagtgttccagggtatactggagcaccacagat
gctcgcaagcgctgtgtatatacatgcaagatagtggagtgccgtcctccagtcgtagag
ccggatatcaacagcactgttgaacatgatgaaaacaggaccattgcccatagtccaaca
tcttttacagaaagttcatcaaaagagagtcaaaacacagctgaaattataagtcctcca
tcaccagaccgacctcctcattcacaaacctctggctcctgttattatcatgtcatctca
aaggtccccaggattcgaacacccagttattctccaacacagagatcccctggctgtcga
ccgttgccttctgcaggaagtcctaccccaaccactcatgaaatagtcacagtaggtgat
cctttactctcctctggacttcgaagcattggctccaggcgtcacagtacctcttcctta
tcaccccagcggtccaaactccggataatgtctccaatgagaactgggaatacttactct
aggaataatgtttcctcagtctccaccaccgggaccgctactgatcttgaatcaagtgcc
aaagtagttgatcatgtcttagggccactgaattcaagtactagtttagggcaaaacact
tccacctcttcaaatttgcaaaggacagtggttactgtaggcaataaaaacagtcacttg
gatggatcttcatcttcagaaatgaagcagtccagtgcttcagacttggtgtccaagagc
tcctctttaaagggagagaagaccaaagtgctgagttccaagagctcagagggatctgca
cataatgtggcttaccctggaattcctaaactggccccacaggttcataacacaacatct
agagaactgaatgttagtaaaatcggctcctttgctgaaccctcttcagtgtcgttttct
tctaaagaggccctctccttcccacacctccatttgagagggcaaaggaatgatcgagac
caacacacagattctacccaatcagcaaactcctctccagatgaagatactgaagtcaaa
accttgaagctatctggaatgagcaacagatcatccattatcaacgaacatatgggatct
agttccagagataggagacagaaagggaaaaaatcctgtaaagaaactttcaaagaaaag
cattccagtaaatcttttttggaacctggtcaggtgacaactggtgaggaaggaaacttg
aagccagagtttatggatgaggttttgactcctgagtatatgggccaacgaccatgtaac
aatgtttcttctgataagattggtgataaaggcctttctatgccaggagtccccaaagct
ccacccatgcaagtagaaggatctgccaaggaattacaggcaccacggaaacgcacagtc
aaagtgacactgacacctctaaaaatggaaaatgagagtcaatccaaaaatgccctgaaa
gaaagtagtcctgcttcccctttgcaaatagagtcaacatctcccacagaaccaatttca
gcctctgaaaatccaggagatggtccagtggcccaaccaagccccaataatacctcatgc
caggattctcaaagtaacaactatcagaatcttccagtacaggacagaaacctaatgctt
ccagatggccccaaacctcaggaggatggctcttttaaaaggaggtatccccgtcgcagt
gcccgtgcacgttctaacatgttttttgggcttaccccactctatggagtaagatcctat
ggtgaagaagacattccattctacagcagctcaactgggaagaagcgaggcaagagatca
gctgaaggacaggtggatggggccgatgacttaagcacttcagatgaagacgacttatac
tattacaacttcactagaacagtgatttcttcaggtggagaggaacgactggcatcccat
aatttatttcgggaggaggaacagtgtgatcttccaaaaatctcacagttggatggtgtt
gatgatgggacagagagtgatactagtgtcacagccacaacaaggaaaagcagccagatt
ccaaaaagaaatggtaaagaaaatggaacagagaacttaaagattgatagacctgaagat
gctggggagaaagaacatgtcactaagagttctgttggccacaaaaatgagccaaagatg
gataactgccattctgtaagcagagttaaaacacagggacaagattccttggaagctcag
ctcagctcattggagtcaagccgcagagtccacacaagtaccccctccgacaaaaattta
ctggacacctataatactgagctcctgaaatcagattcagacaataacaacagtgatgac
tgtgggaatatcctgccttcagacattatggactttgtactaaagaatactccatccatg
caggctttgggtgagagcccagagtcatcttcatcagaactcctgaatcttggtgaagga
ttgggtcttgacagtaatcgtgaaaaagacatgggtctttttgaagtattttctcagcag
ctgcctacaacagaacctgtggatagtagtgtctcttcctctatctcagcagaggaacag
tttgagttgcctctagagctaccatctgatctgtctgtcttgaccacccggagtcccact
gtccccagccagaatcccagtagactagctgttatctcagactcaggggagaagagagta
accatcacagaaaaatctgtagcctcctctgaaagtgacccagcactgctgagcccagga
gtagatccaactcctgaaggccacatgactcctgatcattttatccaaggacacatggat
gcagaccacatctctagccctccttgtggttcagtagagcaaggtcatggcaacaatcag
gatttaactaggaacagtagcacccctggccttcaggtacctgtttccccaactgttccc
atccagaaccagaagtatgtgcccaattctactgatagtcctggcccgtctcagatttcc
aatgcagctgtccagaccactccaccccacctgaagccagccactgagaaactcatagtt
gttaaccagaacatgcagccactttatgttctccaaactcttccaaatggagtgacccaa
aaaatccaattgacctcttctgttagttctacacccagtgtgatggagacaaatacttca
gtattgggacccatgggaggtggtctcacccttaccacaggactaaatccaagcttgcca
acttctcaatctttgttcccttctgctagcaaaggattgctacccatgtctcatcaccag
cacttacattccttccctgcagctactcaaagtagtttcccaccaaacatcagcaatcct
ccttcaggcctgcttattggggttcagcctcctccggatccccaacttttggtttcagaa
tccagccagaggacagacctcagtaccacagtagccactccatcctctggactcaagaaa
agacccatatctcgtctacagacccgaaagaataaaaaacttgctccctctagtacccct
tcaaacattgccccttctgatgtggtttctaatatgacattgattaacttcacaccctcc
cagcttcctaatcatccaagtctgttagatttggggtcacttaatacttcatctcaccga
actgtccccaacatcataaaaagatctaaatctagcatcatgtattttgaaccggcaccc
ctgttaccacagagtgtgggaggaactgctgccacagcggcaggcacatcaacaataagc
caggatactagccacctcacatcagggtctgtgtctggcttggcatccagttcctctgtc
ttgaatgttgtatccatgcaaactaccacaacccctacaagtagtgcgtcagttccagga
cacgtcaccttaaccaacccaaggttgcttggtaccccagatattggctcaataagcaat
cttttaatcaaagctagccagcagagcctggggattcaggaccagcctgtggctttaccg
ccaagttcaggaatgtttccacaactggggacatcacagaccccctctactgctgcaata
acagcggcatctagcatctgtgtgctcccctccactcagactacgggcataacagccgct
tcaccttctggggaagcagacgaacactatcagcttcagcatgtgaaccagctccttgcc
agcaaaactgggattcattcttcccagcgtgatcttgattctgcttcagggccccaggta
tccaactttacccagacggtagacgctcctaatagcatgggactggagcagaacaaggct
ttatcctcagctgtgcaagccagccccacctctcctgggggttctccatcctctccatct
tctggacagcggtcagcaagcccttcagtgccgggtcccactaaacccaaaccaaaaacc
aaacggtttcagctgcctctagacaaagggaatggcaagaagcacaaagtttcccatttg
cggaccagttcttctgaagcacacattccagaccaagaaacgacatccctgacctcaggc
acagggactccaggagcagaggctgagcagcaggatacagctagcgtggagcagtcctcc
cagaaggagtgtgggcaacctgcagggcaagtcgctgttcttccggaagttcaggtgacc
caaaatccagcaaatgaacaagaaagtgcagaacctaaaacagtggaagaagaggaaagt
aatttcagctccccactgatgctttggcttcagcaagaacaaaagcggaaggaaagcatt
actgagaaaaaacccaagaaaggacttgtttttgaaatttccagtgatgatggctttcag
atctgtgcagaaagtattgaagatgcctggaagtcattgacagataaagtccaggaagct
cgatcaaatgcccgcctaaagcagctctcatttgcaggtgttaacggtttgaggatgctg
gggattctccatgatgcagttgtgttcctcattgagcagctgtctggtgccaagcactgt
cgaaattacaaattccgtttccacaagccagaggaggccaatgaaccccccttgaaccct
cacggctcagccagggctgaagtccacctcaggaagtcagcatttgacatgtttaacttc
ctggcttctaaacatcgtcagcctcctgaatacaaccccaatgatgaagaagaggaggag
gtacagctgaagtcagctcggagggcaactagcatggatctgccaatgcccatgcgcttc
cggcacttaaaaaagacttctaaggaggcagttggtgtctacaggtctcccatccatggc
cggggtcttttctgtaagagaaacattgatgcaggtgagatggtgattgagtatgccggc
aacgtcatccgctccatccagactgacaagcgggaaaagtattacgacagcaagggcatt
ggttgctatatgttccgaattgatgactcagaggtagtggatgccaccatgcatggaaat
gctgcacgcttcatcaatcactcgtgtgagcctaactgctattctcgggtcatcaatatt
gatgggcagaagcacattgtcatctttgccatgcgtaagatctaccgaggagaggaactc
acttacgactataagttccccattgaggatgccagcaacaagctgccctgcaactgtggc
gccaagaaatgccggaagttcctaaactaa |
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