KEGG   Homo sapiens (human): 4299
Entry
4299              CDS       T01001                                 
Symbol
AFF1, AF4, FEL, MLLT2, PBM1
Name
(RefSeq) ALF transcription elongation factor 1
  KO
K15184  AF4/FMR2 family member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
  Element
N00119  MLL-AF4 fusion to transcriptional activation
Disease
H00001  B-cell acute lymphoblastic leukemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    4299 (AFF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    4299 (AFF1)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     4299 (AFF1)
SSDB
Motif
Pfam: AF-4 AFF4_CHD AF4_int BRD4_CDT
Other DBs
NCBI-GeneID: 4299
NCBI-ProteinID: NP_005926
OMIM: 159557
HGNC: 7135
Ensembl: ENSG00000172493
UniProt: P51825 Q14C88
Structure
Position
4:86935011..87141039
AA seq 1210 aa
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNM
LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPA
SGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGY
CPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQ
DQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTS
SMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS
SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTV
GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK
PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKG
SRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS
SSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA
SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFD
KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYS
ETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKH
FESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQN
MTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGF
QQLQELTKTP
NT seq 3633 nt   +upstreamnt  +downstreamnt
atggcagcccagtcaagtttgtacaatgacgacagaaacctgcttcgaattagagagaag
gaaagacgcaaccaggaagcccaccaagagaaagaggcatttcctgaaaagattcccctt
tttggagagccctacaagacagcaaaaggtgatgagctgtctagtcgaatacagaacatg
ttgggaaactacgaagaagtgaaggagttccttagtactaagtctcacactcatcgcctg
gatgcttctgaaaataggttgggaaagccgaaatatcctttaattcctgacaaagggagc
agcattccatccagctccttccacactagtgtccaccaccagtccattcacactcctgcg
tctggaccactttctgttggcaacattagccacaatccaaagatggcgcagccaagaact
gaaccaatgccaagtctccatgccaaaagctgcggcccaccggacagccagcacctgacc
caggatcgccttggtcaggaggggttcggctctagtcatcacaagaaaggtgaccgaaga
gctgacggagaccactgtgcttcggtgacagattcggctccagagagggagctttctccc
ttaatctctttgccttccccagttccccctttgtcacctatacattccaaccagcaaact
cttccccggacgcaaggaagcagcaaggttcatggcagcagcaataacagtaaaggctat
tgcccagccaaatctcccaaggacctagcagtgaaagtccatgataaagagacccctcaa
gacagtttggtggcccctgcccagccgccttctcagacatttccacctccctccctcccc
tcaaaaagtgttgcaatgcagcagaagcccacggcttatgtccggcccatggatggtcaa
gatcaggcccctagtgaatcccctgaactgaaaccactgccggaggactatcgacagcag
acctttgaaaaaacagacttgaaagtgcctgccaaagccaagctcaccaaactgaagatg
ccttctcagtcagttgagcagacctactccaatgaagtccattgtgttgaagagattctg
aaggaaatgacccattcatggccgcctcctttgacagcaatacatacgcctagtacagct
gagccatccaagtttcctttccctacaaaggactctcagcatgtcagttctgtaacccaa
aaccaaaaacaatatgatacatcttcaaaaactcactcaaattctcagcaaggaacgtca
tccatgctcgaagacgaccttcagctcagtgacagtgaggacagtgacagtgaacaaacc
ccagagaagcctccctcctcatctgcacctccaagtgctccacagtcccttccagaacca
gtggcatcagcacattccagcagtgcagagtcagaaagcaccagtgactcagacagttcc
tcagactcagagagcgagagcagttcaagtgacagcgaagaaaatgagcccctagaaacc
ccagctccggagcctgagcctccaacaacaaacaaatggcagctggacaactggctgacc
aaagtcagccagccagctgcgccaccagagggccccaggagcacagagcccccacggcgg
cacccagagagtaagggcagcagcgacagtgccacgagtcaggagcattctgaatccaaa
gatcctccccctaaaagctccagcaaagccccccgggccccacccgaagccccccacccc
ggaaagaggagctgtcagaagtctccggcacagcaggagcccccacaaaggcaaaccgtt
ggaaccaaacaacccaaaaaacctgtcaaggcctctgcccgggcaggttcacggaccagc
ctgcagggggaaagggagccagggcttcttccctatggctcccgagaccagacttccaaa
gacaagcccaaggtgaagacgaaaggacggccccgggccgcagcaagcaacgaacccaag
ccagcagtgcccccctccagtgagaagaagaagcacaagagctccctccctgccccctct
aaggctctctcaggcccagaacccgcgaaggacaatgtggaggacaggacccctgagcac
tttgctcttgttcccctgactgagagccagggcccaccccacagtggcagcggcagcagg
actagtggctgccgccaagccgtggtggtccaggaggacagccgcaaagacagactccca
ttgcctttgagagacaccaagctgctctcaccgctcagggacactcctcccccacaaagc
ttgatggtgaagatcaccctagacctgctctctcggataccccagcctcccgggaagggg
agccgccagaggaaagcagaagataaacagccgcccgcagggaagaagcacagctctgag
aagaggagctcagacagctcaagcaagttggccaaaaagagaaagggtgaagcagaaaga
gactgtgataacaagaaaatcagactggagaaggaaatcaaatcacagtcatcttcatct
tcatcctcccacaaagaatcttctaaaacaaagccctccaggccctcctcacagtcctca
aagaaggaaatgctccccccgccacccgtgtcctcgtcctcccagaagccagccaagcct
gcacttaagaggtcaaggcgggaagcagacacctgtggccaggaccctcccaaaagtgcc
agcagtaccaagagcaaccacaaagactcttccattcccaagcagagaagagtagagggg
aagggctccagaagctcctcggagcacaagggttcttccggagatactgcaaatcctttt
ccagtgccttctttgccaaatggtaactctaaaccagggaagcctcaagtgaagtttgac
aaacaacaagcagaccttcacatgagggaggcaaaaaagatgaagcagaaagcagagtta
atgacggacagggttggaaaggcttttaagtacctggaagccgtcttgtccttcattgag
tgcggaattgccacagagtctgaaagccagtcatccaagtcagcttactctgtctactca
gaaactgtagatctcattaaattcataatgtcattaaaatccttctcagatgccacagcg
ccaacacaagagaaaatatttgctgttttatgcatgcgttgccagtccattttgaacatg
gcgatgtttcgttgtaaaaaagacatagcaataaagtattctcgtactcttaataaacac
ttcgagagttcttccaaagtcgcccaggcaccttctccatgcattgcaagcacaggcaca
ccatcccctctttccccaatgccttctcctgccagctccgtagggtcccagtcaagtgct
ggcagtgtggggagcagtggggtggctgccactatcagcaccccagtcaccatccagaat
atgacatcttcctatgtcaccatcacatcccatgttcttaccgcctttgacctttgggaa
caggccgaggccctcacgaggaagaataaagaattctttgctcggctcagcacaaatgtg
tgcaccttggccctcaacagcagtttggtggacctggtgcactatacacgacagggtttt
cagcagctacaagaattaaccaaaacaccttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (52)   
   KEGG ORTHOLOGY (1)   
   RefGene (46)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (27)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (56)   
   RefSeq(nuc) (24)   
   GenBank (16)   
   EMBL (16)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (148)   

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