KEGG   Homo sapiens (human): 4321
Entry
4321              CDS       T01001                                 
Symbol
MMP12, HME, ME, MME, MMP-12
Name
(RefSeq) matrix metallopeptidase 12
  KO
K01413  matrix metalloproteinase-12 (macrophage elastase) [EC:3.4.24.65]
Organism
hsa  Homo sapiens (human)
Drug target
Marimastat: D03795
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4321 (MMP12)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.65  macrophage elastase
     4321 (MMP12)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4321 (MMP12)
SSDB
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Astacin Reprolysin_3 Metallopep Peptidase_M54 Peptidase_M66 Reprolysin_5 Reprolysin_4
Other DBs
NCBI-GeneID: 4321
NCBI-ProteinID: NP_002417
OMIM: 601046
HGNC: 7158
Ensembl: ENSG00000262406
UniProt: P39900
Structure
Position
11:complement(102862736..102874982)
AA seq 470 aa
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
NT seq 1413 nt   +upstreamnt  +downstreamnt
atgaagtttcttctaatactgctcctgcaggccactgcttctggagctcttcccctgaac
agctctacaagcctggaaaaaaataatgtgctatttggtgaaagatacttagaaaaattt
tatggccttgagataaacaaacttccagtgacaaaaatgaaatatagtggaaacttaatg
aaggaaaaaatccaagaaatgcagcacttcttgggtctgaaagtgaccgggcaactggac
acatctaccctggagatgatgcacgcacctcgatgtggagtccccgatgtccatcatttc
agggaaatgccaggggggcccgtatggaggaaacattatatcacctacagaatcaataat
tacacacctgacatgaaccgtgaggatgttgactacgcaatccggaaagctttccaagta
tggagtaatgttacccccttgaaattcagcaagattaacacaggcatggctgacattttg
gtggtttttgcccgtggagctcatggagacttccatgcttttgatggcaaaggtggaatc
ctagcccatgcttttggacctggatctggcattggaggggatgcacatttcgatgaggac
gaattctggactacacattcaggaggcacaaacttgttcctcactgctgttcacgagatt
ggccattccttaggtcttggccattctagtgatccaaaggccgtaatgttccccacctac
aaatatgttgacatcaacacatttcgcctctctgctgatgacatacgtggcattcagtcc
ctgtatggagacccaaaagagaaccaacgcttgccaaatcctgacaattcagaaccagct
ctctgtgaccccaatttgagttttgatgctgtcactaccgtgggaaataagatctttttc
ttcaaagacaggttcttctggctgaaggtttctgagagaccaaagaccagtgttaattta
atttcttccttatggccaaccttgccatctggcattgaagctgcttatgaaattgaagcc
agaaatcaagtttttctttttaaagatgacaaatactggttaattagcaatttaagacca
gagccaaattatcccaagagcatacattcttttggttttcctaactttgtgaaaaaaatt
gatgcagctgtttttaacccacgtttttataggacctacttctttgtagataaccagtat
tggaggtatgatgaaaggagacagatgatggaccctggttatcccaaactgattaccaag
aacttccaaggaatcgggcctaaaattgatgcagtcttctactctaaaaacaaatactac
tatttcttccaaggatctaaccaatttgaatatgacttcctactccaacgtatcaccaaa
acactgaaaagcaatagctggtttggttgttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (85)   
   PDB (85)   
Protein domain (10)   
   Pfam (10)   
All databases (139)   

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